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Featured researches published by Enikő Tóth.


Investigative Ophthalmology & Visual Science | 2011

Differentially Expressed Genes Associated with Human Limbal Epithelial Phenotypes: New Molecules That Potentially Facilitate Selection of Stem Cell-Enriched Populations

Lili Takács; Enikő Tóth; Gergely Losonczy; Attila Szanto; Tomi Bähr-Ivacevic; Vladimir Benes; András Berta; György Vereb

PURPOSE The aim of this study was to identify differentially expressed genes in the human limbal epithelium by microarray analysis. METHODS Total RNA isolates of human limbal and central corneal epithelia were used after transcription for hybridization on whole human genome expression microarrays. A set of differentially expressed genes detected by both microarrays was established. In the case of eight selected molecules, microarray results were confirmed by qRT-PCR, and protein expression in the cornea was examined by confocal immunofluorescence microscopy. Colocalization with the putative stem cell marker C/EBPδ was also examined. RESULTS The authors established a database of 126 limbal overexpressed genes. qRT-PCR confirmed microarray results in all examined cases (SPON1, IFITM1, ITM2A, PHLDA1, CXCR4, FZD7, DCT, DKK4). Limbal localization of the protein product of SPON1, IFITM1, ITM2A, CXCR4, and DKK4 was shown with confocal immunofluorescence microscopy. SPON1, IFITM1, and ITM2A signals mostly colocalized with C/EBPδ-positive putative resting limbal stem cells. CONCLUSIONS By detecting several new differentially expressed genes in the human corneal limbus, this study further expands current knowledge on the molecular signature of limbal epithelial stem cells. Plasma membrane localization of IFITM1 and ITM2A suggests their potential usefulness as targets to select stem cell-enriched populations from the limbal epithelium.


Croatian Medical Journal | 2014

Single acute stress-induced progesterone and ovariectomy alter cardiomyocyte contractile function in female rats

Judit Kalász; Enikő Tóth; Beáta Bódi; Miklós Fagyas; Attila Tóth; Bhattoa Harjit Pal; Sandor G. Vari; Marta Balog; Senka Blažetić; Marija Heffer; Zoltán Papp; Attila Borbély

Aim To assess how ovarian-derived sex hormones (in particular progesterone) modify the effects of single acute stress on the mechanical and biochemical properties of left ventricular cardiomyocytes in the rat. Methods Non-ovariectomized (control, n = 8) and ovariectomized (OVX, n = 8) female rats were kept under normal conditions or were exposed to stress (control-S, n = 8 and OVX-S, n = 8). Serum progesterone levels were measured using a chemiluminescent immunoassay. Left ventricular myocardial samples were used for isometric force measurements and protein analysis. Ca2+-dependent active force (Factive), Ca2+-independent passive force (Fpassive), and Ca2+-sensitivity of force production were determined in single, mechanically isolated, permeabilized cardiomyocytes. Stress- and ovariectomy-induced alterations in myofilament proteins (myosin-binding protein C [MyBP-C], troponin I [TnI], and titin) were analyzed by sodium dodecyl sulfate gel electrophoresis using protein and phosphoprotein stainings. Results Serum progesterone levels were significantly increased in stressed rats (control-S, 35.6 ± 4.8 ng/mL and OVX-S, 21.9 ± 4.0 ng/mL) compared to control (10 ± 2.9 ng/mL) and OVX (2.8 ± 0.5 ng/mL) groups. Factive was higher in the OVX groups (OVX, 25.9 ± 3.4 kN/m2 and OVX-S, 26.3 ± 3.0 kN/m2) than in control groups (control, 16.4 ± 1.2 kN/m2 and control-S, 14.4 ± 0.9 kN/m2). Regarding the potential molecular mechanisms, Factive correlated with MyBP-C phosphorylation, while myofilament Ca2+-sensitivity inversely correlated with serum progesterone levels when the mean values were plotted for all animal groups. Fpassive was unaffected by any treatment. Conclusion Stress increases ovary-independent synthesis and release of progesterone, which may regulate Ca2+-sensitivity of force production in left ventricular cardiomyocytes. Stress and female hormones differently alter Ca2+-dependent cardiomyocyte contractile force production, which may have pathophysiological importance during stress conditions affecting postmenopausal women.


Acta Linguistica Hungarica | 2016

The pronoun interpretation problem in child Hungarian

György Rákosi; Enikő Tóth

In a number of languages, children have problems with the interpretation of pronouns if a potential local antecedent is present. There is an intensive debate on whether this effect is due to a delayed acquisition of Principle B, or it is the result of pragmatic or processing difficulties that children face in interpretation tasks. We conducted two experiments involving a picture-sentence verification task to investigate whether the Pronoun Interpretation Problem exists in Hungarian child language. We found that the Problem is present if the test sentences are given in isolation, but it disappears if a minimally coherent discourse is created. We argue that our results support the view that the binding principles are innate and do not need to be acquired, but children have problems with computing coreference options in certain contexts (Reinhart 2004; 2006; 2011). Coherent discourse allows children to accommodate pronouns with close to adult-like success because in this case they do not calculate local core...


Orvosi Hetilap | 2009

Surgical treatment of ocular surface diseases

László Módis; Enikő Tóth; András Berta

Pathomechanisms leading to ocular surface diseases are difficult to influence, and conservative treatment efforts are inefficient in most cases. However, the development of microsurgical techniques, the clinical application of molecular biologic methods and the localisation and identification of the function of limbal stem cells made it possible to achieve visual improvement and quality of life in these cases. The authors review the methods of tissue harvesting, cell culturing, transplantation techniques and indications. They provide a detailed survey on the most recommended modern surgical procedures, especially focusing on amniotic membrane and limbal stem cell transplantation.


Cancer Letters | 2008

Trastuzumab decreases the number of circulating and disseminated tumor cells despite trastuzumab resistance of the primary tumor

Márk Barok; Margit Balázs; Péter Nagy; Zsuzsa Rákosy; Andrea Treszl; Enikő Tóth; István Juhász; John W. Park; Jorma Isola; György Vereb; János Szöllősi


Archive | 2005

Amnionmembrán-transzplantációval kezelt corneabetegségek

László Módis; Zita Steiber; T. Komár; Enikő Tóth; András Berta


Archive | 2016

Magát és esetleg őt is

György Rákosi; Enikő Tóth


Lingüística | 2016

Indexical demonstratives and identificational focus in Hungarian

Enikő Tóth; Péter Csatár


Jelentés és Nyelvhasználat | 2016

Magát és esetleg őt is? Névmások a magyar gyereknyelvben

György Rákosi; Enikő Tóth


Jelentés és Nyelvhasználat | 2015

Egy interfész jelenség: indexikális demonstratívumok azonosító fókuszban

Enikő Tóth; Péter Csatár

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András Kertész

Hungarian Academy of Sciences

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