Ennio Leão

C-reactive protein as an indicator of low intensity inflammation in children and adolescents with and without obesity.

OBJECTIVES To determine the levels of high sensitivity C-reactive protein (hsCRP) in children/adolescents with and without obesity and their correlation with body mass index (BMI) and clinical and laboratory variables. METHODS A cross-sectional study comparing two parallel groups, one a group of overweight or obese children/adolescents (obesity group, n = 131) and the other a control group of children/adolescents without obesity (control group, n = 114). High sensitivity nephelometry was used to determine hsCRP concentrations. RESULTS The obesity group exhibited greater hsCRP concentrations than the control group (p < 0.0005). There were relationships between hsCRP and BMI (p < 0.0001) and hsCRP and triglycerides (p = 0.05). The relationship between hsCRP and triglycerides was attenuated by adjustment for BMI, losing its statistical significance (p = 0.10). CONCLUSIONS The hsCRP concentrations increased as BMI increased. The majority of individuals who were not overweight exhibited hsCRP concentrations of less than 2 mg/L.

Proteína C reativa como indicador de inflamação de baixa intensidade em crianças e adolescentes com e sem obesidade

OBJECTIVES: To determine the levels of high sensitivity C-reactive protein (hsCRP) in children/adolescents with and without obesity and their correlation with body mass index (BMI) and clinical and laboratory variables. METHODS: A cross-sectional study comparing two parallel groups, one a group of overweight or obese children/adolescents (obesity group, n = 131) and the other a control group of children/adolescents without obesity (control group, n = 114). High sensitivity nephelometry was used to determine hsCRP concentrations. RESULTS: The obesity group exhibited greater hsCRP concentrations than the control group (p < 0.0005). There were relationships between hsCRP and BMI (p < 0.0001) and hsCRP and triglycerides (p = 0.05). The relationship between hsCRP and triglycerides was attenuated by adjustment for BMI, losing its statistical significance (p = 0.10). CONCLUSIONS: The hsCRP concentrations increased as BMI increased. The majority of individuals who were not overweight exhibited hsCRP concentrations of less than 2 mg/L.

Congenital generalized lipodystrophy

OBJETIVO: Apresentar as principais caracteristicas clinicas e bioquimicas da lipodistrofia generalizada congenita, desordem rara e pouco conhecida dos pediatras. DESCRICAO: Nos ambulatorios de Doencas Nutricionais e de Endocrinologia do Servico de Pediatria do Hospital das Clinicas da UFMG, foram identificados oito pacientes com lipodistrofia generalizada congenita. As caracteristicas clinicas comuns a todos os casos foram hipertrofia muscular, lipoatrofia generalizada e aparencia acromegalica. Manifestacoes clinico-laboratoriais associadas incluiram acantose nigricans em cinco pacientes, hepatoesplenomegalia em seis, hipertrigliceridemia com baixas concentracoes de HDL em sete, hipertrofia cardiaca em um e diabetes melito secundario em dois pacientes. Todos os pacientes estao em controle clinico e dietetico, visando a correcao ou prevencao dos disturbios metabolicos. COMENTARIOS: As caracteristicas fenotipicas da lipodistrofia generalizada congenita sao bem identificadas, possibilitando o diagnostico clinico na maioria dos casos. Trata-se de uma sindrome rara que ilustra a importância do funcionamento normal do tecido adiposo para a maioria dos processos metabolicos vitais do organismo. O seu melhor conhecimento podera abrir novos horizontes em estudos de doencas mais prevalentes como o diabetes melito e a obesidade.

[Late hemorragic disease of the newborn: case report]

OBJECTIVE: In this study the authors review this subject, and call attention for the late hemorrhagic disease of the newborn, due to the severity and higher risk of mortality and neurological sequelae.METHODS: In this article, four cases of children, age raging from 12 to 21 days, with late hemorrhagic disease associated with vitamin K deficiency were reported. RESULTS: All newborns had multiple hemorrhagic manifestations of the disease. The systems more affected were digestive tract, urinary system, umbilical cord, respiratory system and nervous system.CONCLUSION: Three forms of hemorrhagic disease of newborn have been related with vitamin K deficiency. However, late vitamin K deficiency bleeding is not common and may not be diagnosed by pediatrician. This form of disease can be prevented by vitamin K prophylaxis administration after birth.