Enoch Callaway

Relationship between reaction time and electroencephalographic alpha phase.

Demonstrations of a relationship between human 8 to 13 per second (alpha) electroencephalographic activity and simple visual reaction time can be made at reliable levels of confidence by (i) sampling reaction times to stimuli given at phases of the alpha cycle 10 msec apart, (ii) selecting the phase with the slowest reaction times, and (iii) collecting enough reaction times to stimuli at this and some other control phase for statistical comparison.

Coupling between cortical potentials from different areas.

At any instant, the electroencephalogram can be classified as to (i) polarity and (ii) direction of change in polarity. This classification provides a way to measure coupling between cortical areas. The technique is simple, yet of wide potential utility for studying functional relationships between cortical areas. The results of applying this technique suggest how the potentials giving rise to the electroencephalogram may play a role in information processing in the central nervous system.

Effects of pyridoxine and magnesium on autistic symptoms—Initial observations

In an open trial, a heterogeneous group of 44 children with autistic symptoms were treated with large doses of vitamin B6 and magnesium. Clinical improvement with worsening on termination of the trial was observed in 15 children. Thirteen responders and 8 nonresponders were retested in a 2-week, crossover, double-blind trial, and the responses to the open trial were confirmed.

Evoked potential variability: Effects of age, amplitude and methods of measurement ☆

Abstract Visual and auditory evoked potentials (EPs) were recorded from 120 children of 6–15 years of age. EP variability was measured using a variety of techniques. All of these techniques showed that variability decreased with increasing age. Similar measures applied to background EEG activity showed less adequate discrimination of age, suggesting that the effects observed are not entirely due to changes of background EEG activity. This contention is further supported by the polarity histogram measurement of variability, which indicates that variability of the late EP components (100 msec and later) decreases with increasing age more than does variability of earlier components. With some measures, variability is positively correlated with amplitude; with others, the correlations are negative. With all of the measures, variability is negatively correlated with age. This would indicate that the increasing EP stability with age is not a function of amplitude changes. These findings also illustrate some of the various EP variability measures available, how they relate to each other and how they are related to AEP amplitude.

Combined effects of alcohol and sleep deprivation in normal young adults

The effect of combining sleep deprivation and moderate alcohol consumption in male college students differed from the effects of each treatment alone. Following either alcohol or sleep deprivation, there was mild performance impairment, decreased alertness and reduced amplitude and increased latency of cortical evoked potential (EP) components. Heart rate increased after alcohol and anxiety increased after sleep deprivation. When alcohol and sleep deprivation were combined, antagonistic effects were found for most measures (reaction time, heart rate, alertness, anxiety, latency of early EP components), but synergistic effects also occurred (performance accuracy, latency of late EP components). These effects were found in a doubleblind experiment using 24 subjects. The experimental treatments were alcohol doses of 0, 0.45 and 0.90 ml/kg of 95% ethanol and 0 and 26 h of sleep deprivation.

The effect of attentional effort on visual evoked potential N1 latency

The latency of the visual evoked potential N1 component evoked by nontarget stimuli increases with an increased attention to nontarget stimuli. The latency increase seems related to a general effort at processing, rather than any early filtering. This phenomenon is illustrated in one study of hyperactive children and another of normal young adults. The literature of this phenomenon is reviewed, and various explanations are considered. It does not appear to be a result of a slow negative wave, but rather a genuine effect of one aspect of attention on N1.

Visual evoked potential changes induced by methylphenidate in hyperactive children: Dose/response effects

Visual event related potentials (ERP) were recorded from 21 hyperactive children aged 7-13 years under two attention conditions at 4 levels of methylphenidate dose (placebo, low, medium and high). ERP measures were very sensitive to age (under or over 10 years) and attention condition, but less sensitive to drug dose. There appeared to be two classes of drug dose effect on ERP amplitude, those that changed monotonically with dose and those from which dose interacted with attention non-monotonically. Drug effect on ERP amplitude may also depend on age so that opposite effects may occur in young and old children. No latency measures showed a dose effect. It appears that methylphenidate can speed reaction times without shortening ERP latency. This suggests the drug acts more on response-related processes than on stimulus evaluation.

Time shipt evoked potentials (TSEPs): Method and basic results☆

A simple technique for generating averaged evoked potentials to auditory signals that appear to move in space is described. Shifts in the apparent location of the signal were created by digitally delaying the output of a white noise generator with a minicomputer. The two channels were reconverted to two analog signals and presented binaurally through headphones. Shifts inthe apparent location of the signal produced a time shifted evoked potential (TSEP) that was not present during monaural control runs. TSEP amplitudes were largest near the vertex and varied as a function of the presentation format.

Effects of two doses of methylphenidate on verbal information processing in hyperactive children

Nine hyperactive children participated in three sessions. During each they were given one of three drugs (placebo, 10 mg, or 21 mg of methylphenidate) in a double-blind crossover study. Following drug administration they were tested on three cognitive tasks. For one task, structural, acoustic, or semantic degrees of encoding of verbal information were induced. Memory for the verbal information was then tested. The 10-mg dose resulted in overall improvement of word recognition and recall. The 21-mg dose did not result in improvement. Amount of improvement was not related to degree of encoding of words. Two other tasks, learning a list of words and visual search of letters from a briefly presented display, were not affected by either the 10- or 21-mg dose. The results indicate that verbal learning can be facilitated by a low dose of methylphenidate but that the dose range may be narrow. Also, certain individuals did not respond favorably to either dose. In discussing the results, the possibility is presented that methylphenidate-induced facilitation may be restricted to certain types of learning or certain methods of assessing retrieval of information.

Factors influencing the relationship between alpha activity and visual reaction time

Abstract Studies have been reported concerning the relationship between alpha activity and visual reaction time. Evidence is presented to indicate that for a given individual there is an enduring tendency for particular phases of the alpha cycle to be associated with fastest or slowest reaction times. Evidence is also presented to indicate that the alpha phase at which stimulation evokes slowest reaction time is not significantly or consistently shifted by altering the stimulus intensity. This would suggest that alpha phase may be indirectly related to cortical excitability, and stimulus intensity may alter this relationship; or else that alpha phase may become related to reaction time much earlier in the course of neural events than has been suspected.