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Dive into the research topics where Ercole Rao is active.

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Featured researches published by Ercole Rao.


Science | 2017

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Ling Xu; Amarendra Pegu; Ercole Rao; Nicole A. Doria-Rose; Jochen Beninga; Krisha McKee; Dana M. Lord; Ronnie Wei; Gejing Deng; Mark K. Louder; Stephen D. Schmidt; Zachary Mankoff; Lan Wu; Mangaiarkarasi Asokan; Christian Beil; Christian Lange; Wulf Dirk Leuschner; Jochen Kruip; Rebecca Sendak; Young Do Kwon; Tongqing Zhou; Xuejun Chen; Robert T. Bailer; Misook Choe; Lawrence J. Tartaglia; Dan H. Barouch; Sijy O’Dell; John-Paul Todd; Dennis R. Burton; Mario Roederer

A triple threat for HIV The HIV virus continually evolves tricks to evade elimination by the host. Prevention and a cure will likely rely on broadly neutralizing antibodies that can recognize and conquer multiple viral strains or subtypes. Xu et al. engineered a single antibody molecule to recognize three highly conserved proteins needed for HIV infection (see the Perspective by Cohen and Corey). This “trispecific” antibody uses two sites (V1V2 and MPER) to bind HIV-infected cells, while the third site (CD4bs) recruits killer T lymphocytes that can eliminate the virus. When tested against >200 different HIV strains, trispecific antibodies were highly potent and broadly neutralized ∼99% of HIV viruses. This approach could potentially simplify HIV treatment regimens and improve therapy response. Science, this issue p. 85; see also p. 46 Engineered trispecific antibodies interact with three independent HIV-1 envelope determinants and prevent infection. The development of an effective AIDS vaccine has been challenging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We engineered trispecific antibodies (Abs) that allow a single molecule to interact with three independent HIV-1 envelope determinants: the CD4 binding site, the membrane-proximal external region (MPER), and the V1V2 glycan site. Trispecific Abs exhibited higher potency and breadth than any previously described single bnAb, showed pharmacokinetics similar to those of human bnAbs, and conferred complete immunity against a mixture of simian-human immunodeficiency viruses (SHIVs) in nonhuman primates, in contrast to single bnAbs. Trispecific Abs thus constitute a platform to engage multiple therapeutic targets through a single protein, and they may be applicable for treatment of diverse diseases, including infections, cancer, and autoimmunity.


Archive | 2013

Dual Variable Region Antibody-Like Binding Proteins Having Cross-Over Binding Region Orientation

Nicolas Baurin; Chirstian Biel; Carsten Corvey; Christian Lange; Danxi Li; Vincent Mikol; Anke Steinmetz; Ercole Rao


Archive | 2008

ANTIBODIES THAT BIND IL-4 AND/OR IL-13 AND THEIR USES

Ercole Rao; Vincent Mikol; Danxi Li; Jochen Kruip; Matthew Davison


Archive | 2010

Novel antagonist antibodies and their fab fragments against gpvi and uses thereof

Nicolas Baurin; Francis Blanche; Beatrice Cameron; Carsten Corvey; Tarik Dabdoubi; Christian Engel; Peter Florian; Ingo Focken; Katja Kroll; Jochen Kruip; Christian Lange; Thomas Langer; Martin Lorenz; Vincent Mikol; Ercole Rao; Peter Wonerow


18th International Colloquium on Lung and Airway Fibrosis | 2014

SAR156597, an IL4/IL13 bi-specific mAb, possesses a unique MoA in inhibition of IL13 signaling

H. Yu; Christian Lange; Anja Wille; Ulrike Siebers; Ercole Rao; Robert Resnick; Mei Duguid; Alla Pritsker; Corinne Esperet; Christina Soubrane; Rachel Yabkowitz; Arun Subramaniam


Journal of Clinical Oncology | 2018

An open-label, first-in-human, dose escalation study of a novel CD3-CD123 bispecific T-cell engager administered as a single agent by intravenous infusion in patients with relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, or high risk myelodysplastic syndrome.

Nicolas Boissel; Stéphane de Botton; Xavier Thomas; Ercole Rao; Hélène Bonnevaux; Chantal Rubin-Carrez; Stéphane Guerif; Eric Beys; Alice Gosselin; Anne-Laure Bauchet; Valery Novikov; Elma Fernandes; Dmitri Wiederschain; Emanuel A. Palatinsky; Karl Hsu; Paula G. Fraenkel


Cancer Research | 2018

Abstract 1785: Pre-clinical development of a novel CD3-CD123 bispecific T-cell engager using Cross-Over-Dual-Variable-Domain (CODV) format for the treatment of acute myeloid leukemia (AML)

Hélène Bonnevaux; Stéphane Guerif; Jana Albrecht; Erwan Jouannot; Laurent Bassinet; Agnès Vergezac; Christian Beil; Christian Lange; Wulf Dirk Leuschner; Anne Caron; Céline Amara; Cedric Barriere; Justine Siavellis; Valerie Bardet; Ernesto Luna; Donald Drake; Ercole Rao; Corina Oprea; Peter Wonerow; Chantal Carrez; Veronique Blanc; Karl Hsu; Dmitri Wiederschain; Paula G. Fraenkel


Archive | 2017

DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEIN WITH ORIENTATION OF CROSS-LINKING REGION

Nicolas Baurin; Chirstian Biel; Carsten Corvey; Christian Lange; Li Dan-Xi; Vincent Mikol; Anke Steinmetz; Ercole Rao


Archive | 2016

Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection

Zhi-Yong Yang; Gary J. Nabel; Ling Xu; Ronnie Wei; Huawei Qiu; Jochen Beninga; Jochen Kruip; Ercole Rao; Wulf Dirk Leuschner; Christian Beil; Christian Lange; Mark Connors; John Mascola; Richard A. Koup; Jinghe Huang; Nicole A. Doria-Rose; Tongqing Zhou; Peter D. Kwong; Young Do Kwon; Amarendra Pegu


Archive | 2016

Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123

Jana Albrecht; Cedric Barriere; Christian Beil; Jochen Beninga; Chantal Carrez; Stéphane Guerif; Katja Kroll; Christian Lange; Cendrine Lemoine; Wulf-Dirk Leuschner; Ercole Rao; Marion Schneider; Marie-Cécile Wetzel; Peter Wonerow

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Francis Blanche

Centre national de la recherche scientifique

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Amarendra Pegu

National Institutes of Health

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