Erdoğan Unur

Effect of age, breast size, menopausal and hormonal status on mammographic skin thickness.

Background/purpose: The localized or generalized skin thickness detected on mammography may reflect an underlying pathology of breast or a systemic disease involving the skin. The aim of this report is to describe the range of normal breast skin thickness in women using a film‐screen mammographic technique.

CT anatomy of pterygopalatine fossa and its communications: a pictorial review

In this article, we present a pictorial review computed tomography (CT) anatomy of pterygopalatine fossa and its communications. Since it represents a major pathway for spread of inflammatory or neoplastic disease between the various compartments, being familiar with the high resolution CT appearance of pterygopalatine fossa and its communications is necessary in selected cases. The diagnostic difficulties in determining the intercompartmental spread is discussed.

Influence of gilaburu (Viburnum opulus) juice on 1,2-dimethylhydrazine (DMH)-induced colon cancer.

In this study, the effects of gilaburu (Viburnum opulus) juice on colon tumorogenesis were investigated. Eight weeks old Balb-C male mice received subcutaneous injections of 1,2-dimethylhydrazine (DMH) (20 mg/kg body weight) once a week for 12 weeks. Both the sham control (group 1) and the DMH control (group 2) groups received drinking water alone, whereas the mice of groups 3 and 4 received gilaburu juice for 30 weeks (started with first DMH injection) and for 18 weeks (started after last DMH injection), respectively. Eighteen weeks after the last DMH injection, all mice were killed and the histogenesis of colon tumors was investigated from the paraffin-embedded sections of colon, which were stained with hematoxylin–eosin. The sites and incidences of tumoral lesions (low-grade dysplasia, high-grade dysplasia, intramucosal carcinoma and invasive carcinoma) were analyzed and compared with control. The results showed that the body weights of the mice were similar in all the groups. No tumoral lesions were found in group 1. Colon tumors developed in all DMH-treated mice (groups 2, 3 and 4). In these groups, the greatest numbers of tumor lesions were detected in the distal colon, followed by the mid-colon and only a few in the proximal colon. There was a reduction in the mean total number of tumor lesion in groups 3 (8.5) and 4 (8.3), when compared to group 2 (11.3). The incidence of invasive carcinoma in group 3 was significantly lower than group 2 (p < 0.05). On the basis of these results, we conclude that gilaburu juice may be useful for the prevention of colon cancer at the initiation stage.

Effects of intraperitoneal administration of the phenytoin on the skeletal system of rat fetus

This study was conducted on determining the effects of phenytoin on the skeletal system of the fetuses of 13 Wistar Albino rats. The female rats were divided into two groups after the vaginal smear test: the group 1 (control group) included 6 individuals, whereas the group 2 (phenytoin group) comprised 7 animals. A dose of 25mg/kg/day phenytoin was administered intraperitoneally to pregnant rats on the 8th-10th days of pregnancy and fetuses were obtained by C-section on the 20th day. A number of 82 fetuses were observed by double staining technique. Their lengths and weights were measured, revealing the statistically significant differences between the two groups (p<0.001). The lengths of the fetuses in the group 2 were determined as to be 14% shorter and the weights 13% lower compared to those in the group 1. Similarly, number of the fetuses obtained in one gestation decreased 9% in the group 2. Ossification of the skull bones in the fetuses of the group 2 was observed eminently to be deteriorated through using dissection microscope and inspection. Costal separation anomaly was observed in the 10 fetuses of the group 2. The separated-laterally located costal components were not attached to the costal arch. Shape malformations in the last two ribs and wide angularity, particularly in the last six ribs, were also determined. This study has documented that intraperitoneal usage of the pheytoin during pregnancy may cause to different skeletal malformations, even with lower doses, in rat fetuses.

Characterization of Tympanic Cavity Volume in Newborns using Computerized Tomography Scanning

El objetivo fue determinar el volumen de la cavidad timpanica (CT) en recien nacidos, informacion no encontrada en la literatura. Se realizaron escaners a traves de tomografia computadorizada (TC) y estudios histologicos en el hueso temporal; los datos se analizaron utilizando un software desarrollado en nuestra institucion. Se obtuvieron imagenes de secciones de TC, de 0,5 mm de grosor, a partir de 5 cadaveres de recien nacidos, los que fueron analizados de forma independiente por dos investigadores expertos. El margen de los cortes de TC fue delineado manualmente y la medicion del area de interes se estimo sobre imagenes ocultas. Despues, se anadieron las mediciones de area de todas las secciones para estimar el volumen total. Las concordancias entre el estudio histologico y los hallazgos de la TC se compararon en cuanto a precision, repetibilidad y confiabilidad. Se utilizaron las medidas de coeficiente de similitud de Jaccard y Dice como metrica de validacion estadistica para evaluar el desempeno del asesor en la medicion manual del volumen. Se observo una buena correlacion del evaluador con los valores medios de Dice, por encima de 0,8 indicando que es factible obtener mediciones coherentes y confiables de volumen. El protocolo propuesto ha demostrado ser preciso para calcular el volumen de la CT, y por lo tanto se puede utilizar para la planificacion prequirurgica asistida o para el diagnostico de alteraciones estructurales en la CT.