Eric B. Rypins

A prospective, randomized clinical investigation ofcholecystoenterostomy and choledochoenterostomy

Summary A prospective, randomized clinical trial was conducted to assess the efficacy of bilioenteric bypass in noncalculous distal biliary obstruction. Thirty-one patients required bypass for either malignant obstruction or chronic pancreatitis and were randomized into two groups: cholecystoenterostomy or choledochoenterostomy with cholecystectomy [ 15, 16 ]. Nine bypasses failed after cholecystoenterostomy and two after choledochoenterostomy (p

Predictability and maintenance of portal flow patterns after small-diameter portacaval H-grafts in man.

Patients undergoing small-diameter (8, 10, 12, and 14 mm) portacaval H-grafts were followed up to 3.5 years. Eight- and 10-mm grafts maintained prograde portal perfusion in 50% of the patients. Follow-up studies performed from 6 to 36 months after surgery show late shunt patency to be 97%. Recurrent variceal hemorrhage has not occurred in any patients. Direction of portal flow after a shunt was related to the size of the portal vein and the size of the shunt. If the shunt diameter was less than 50% that of the portal vein measured on the preoperative angiogram, portal flow was prograde. Encephalopathy rates remained significantly lower in patients with prograde flow after small diameter (8 and 10 mm) portacaval H-graft (p = .0.1). If thrombosis and encephalopathy rates remain low, the small-diameter, polytetrafluoroethylene portacaval H-graft is an attractive alternative to standard portacaval and mesocaval shunts.

99mTc Anti-CD 15 Monoclonal Antibody (LeuTech) Imaging Improves Diagnostic Accuracy and Clinical Management in Patients With Equivocal Presentation of Appendicitis

BackgroundAppendicitis frequently presents in an atypical fashion leading to misdiagnosis or a delay in diagnosis. This is particularly true in early cases where the patient may be erroneously discharged from an emergency department and will invariably return with perforated appendicitis. The standard of care is hospital admission for observation or early operation. Adjunctive imaging tests have been used with mixed results in this equivocal patient population. The authors studied a promising new monoclonal antibody, 99mTc-labeled anti-CD 15 (LeuTech; Palatin Technologies, Inc., Princeton, NJ), which specifically targets neutrophils and may be used for imaging appendicitis. This prospective, multicenter, open-label study evaluated the diagnostic efficacy and clinical impact of LeuTech scintigraphy for detecting appendicitis in patients with an equivocal presentation. MethodsA total of 200 patients (121 females, 79 males; age range 5–86 years; mean age 30.5 ± 16.5 years) completed the study. Management plan was formulated before and reassessed following LeuTech imaging to determine impact on management. Following intravenous injection of LeuTech, the abdomen was imaged with a standard gamma camera for 30 to 90 minutes. ResultsFifty-nine patients had a histopathologic diagnosis of acute appendicitis. LeuTech identified 53 of 59 patients with appendicitis (90% sensitivity) and was negative in 122 of 141 patients without appendicitis (87% specificity). Accuracy, positive predictive value, and negative predictive value were 88%, 74%, and 95%, respectively. Diagnostic efficacy was unchanged in a subgroup of 48 pediatric patients (5–17 years). Diagnostic images for appendicitis were achieved within 8 minutes postinjection in 50% of patients and within 47 minutes in 90% of patients. Significant shifts in patient management decisions were evident following LeuTech results. LeuTech was well tolerated with no serious adverse events reported. ConclusionLeuTech is a convenient, safe, rapid, and sensitive imaging test for diagnosis of appendicitis and favorably impacts patient management in adult and pediatric patients with equivocal signs and symptoms.

Small-diameter portacaval H-graft for variceal hemorrhage.

This report describes the steps in the development of the concept of partial shunting from its earliest stages to the 8-mm-diameter portacaval H-graft. Sequentially decreasing the diameter of the graft from 20 mm did not seem to affect hepatic hemodynamics until the 10-mm-diameter graft was used. At this point, we began to see some patients maintain prograde portal flow. Further reduction in diameter gave a higher rate of patients with prograde flow. Postoperative flow patterns correlate with lower encephalopathy rates and better long-term survival. Important nuances of the operative technique as well as pre- and postoperative management are described.

The emergency portacaval H graft in alcoholic cirrhotic patients: Influence of shunt diameter on clinical outcome

Emergency partial portal decompression was achieved with 8 or 10 mm portacaval H graft shunts combined with aggressive collateral ligation in 18 patients in whom bleeding esophageal varices could not be controlled medically. They were compared with 11 similar risk patients undergoing larger diameter portacaval H graft shunts (12 to 14 mm) for the same indications. Variables studied included 90 day operative mortality, hepatic encephalopathy rates, corrected portal pressure, and variceal re-bleeding. Operative mortality was similar in both groups and correlated strongly with Childs class. However, the incidence of portasystemic encephalopathy in survivors was significantly lower after partial decompression than after total decompression. No patient in either group rebled from varices. We conclude from our series of high risk alcoholic cirrhotic patients, that although mortality after partial and total portal decompression is similar, the lower incidence of encephalopathy in survivors suggests that partial decompression has advantages over total decompression when emergency control of variceal bleeding is necessary.

Influence of portal hemodynamics on long-term survival of alcoholic cirrhotic patients after small-diameter portacaval H grafts

Estimating postoperative survival rates after portasystemic shunt procedures has concerned surgeons during the last 40 years. The relationship between survival and Childs classification has clearly demonstrated the importance of preoperative hepatic functional reserve. Maintaining hepatic portal perfusion has been proposed as an additional protective factor but has never been proved clinically. Our analysis of survival after partial shunting with small-diameter portacaval H grafts has shown that both hepatic functional reserve and postoperative portal perfusion correlate with postoperative survival in alcoholic patients, but the latter was a stronger correlate of long-term survival. A predictive model based on both factors has been described for estimating the overall survival rate of alcoholics after partial shunting with small-diameter portacaval H grafts.

Analysis of nutrient hepatic blood flow after 8-mm versus 16-mm portacaval H-grafts in a prospective randomized trial

BACKGROUND In previous unrandomized studies, we demonstrated that patients undergoing 8-mm diameter portacaval H-grafts with collateral ablation (partial shunts) have lower rates of portasystemic encephalopathy (PSE) postoperatively than patients undergoing total portacaval shunts. We postulated that nutrient hepatic blood flow was greater after partial shunts because 8-mm grafts preserved some portal flow. METHODS To test this hypothesis, we analyzed hepatic hemodynamics in 18 of 30 randomized patients who consented to be studied after complete operative recovery, grouped according to shunt size. We measured nutrient hepatic blood flow using 99m-Tc-Mebrofenin tracer elimination kinetics, and fractionated it into its portal venous and hepatic arterial components. PSE was assessed by blinded observers. Stepwise logistic regression was used to select the variable that best predicted encephalopathy. From 1989 to 1993, we conducted a randomized, prospective trial of partial (8 mm) versus total (16 mm) portacaval H-grafts. Group differences were compared using one-way analysis of variance (ANOVA). RESULTS Hepatic encephalopathy occurred in 2 of 10 patients with partial shunts versus 5 of 8 patients with total shunts. Nutrient hepatic blood flow was significantly higher for partial shunts compared with total shunts (403 +/- 601 versus 243 +/- 17mL/min). Three variables--nutrient hepatic blood flow, portal blood flow, and hepatic arterial flow--were analyzed by stepwise logistic regression. Nutrient hepatic blood flow was selected as the best predictor of hepatic encephalopathy. In this series, PSE did not occur in any patient with more than 325 mL/min of nutrient hepatic blood flow. CONCLUSION These findings provide a physiologic basis for clinical observations demonstrating a lower incidence of PSE with partial shunts and indicates the superiority of partial over total shunts. Partial shunts, by preserving portal flow, maintain higher nutrient hepatic blood flow than total shunts and thus minimize PSE rates.

Radionuclide angiography of the liver and spleen. Noninvasive method for assessing the ratio of portal venous to total hepatic blood flow and portasystemic shunt patency.

Radioactivity verus time curves were generated for the first pass of technetium-99m pertechnetate through the left ventricle, kidneys, spleen and liver, after a 20 mCi peripheral intravenous bolus injection. The rate of change of radioactivity in these organs before recirculation is proportional to blood flow through the organ. The hepatic perfusion index, defined as the ratio of portal flow to total hepatic blood flow, was correlated with the angiographic grade of portal perfusion. The hepatic perfusion index in seven normal subjects was 66.0 +/- 3.4 percent (mean +/- standard error of the mean), and in 22 cirrhotic patients with decreasing angiographic perfusion of grades 1 to 4 the index was 54 +/- 4.6, 37 +/- 2.6, 17 +/- 4.7 and 3 +/- 1.1 percent, respectively. The correlation between the calculated perfusion index and the angiographic grade of portal flow was highly significant (p less than 0.001). The passage of radionuclide through the spleen differed before and after shunt surgery in patients with portal hypertension. The slope to height ratio, based on the downslope of the splenic curve, was significantly greater (p less than 0.01) in the shunted patients and provided a simple index for assessing shunt patency.

Three-phase study of phlebitis in patients receiving peripheral intravenous hyperalimentation

We found clinical phlebitis in 57 of 88 patients with peripheral hyperalimentation (65%). To determine if this was a problem common to all intravenous fluid therapy at our hospital, we performed a point-prevalence study. The prevalence of phlebitis in nonhyperalimentation intravenous patients was 18% (84 of 456 patients). We then performed a randomized, prospective, double-blind trial of sham versus standard in-line filters to determine if bacteria or filterable particulate matter was responsible for phlebitis in the peripheral hyperalimentation group. The standard-filter group had a phlebitis rate of 74% compared with 64% in the sham-filter group. We then eliminated in-line filters and replaced the standard glucose-based solution with a glycerol-based peripheral hyperalimentation solution. The phlebitis rate decreased from 68% to 27% (p less than 0.001). In conclusion, phlebitis in peripheral hyperalimentation patients was probably due to chemical properties of the peripheral hyperalimentation solution rather than bacteria or particulates.