Eric G. Meyer

Anterior cruciate ligament injury induced by internal tibial torsion or tibiofemoral compression.

The knee is one of the most frequently injured joints in the human body. Approximately 91% of ACL injuries occur during sporting activities, usually from a non-contact event. The most common kinetic scenarios related with ACL injuries are internal twisting of the tibia relative to the femur or combined torque and compression during a hard landing. The hypothesis of this study was that the magnitudes and types of motion observed after ACL rupture would significantly change from the relative joint displacements present just before ACL injury. Compression or torsion experiments were conducted on 7 pairs of knee joints with repetitive tests at increasing intensity until catastrophic failure. ACL injury was documented in all cases at 5.4+/-2kN of TF compression or 33+/-13Nm of internal tibial torque. The femur displaced posteriorly relative to the tibia in pre-failure and with a higher magnitude in failure tests under both loading conditions. In compression experiments there was internal rotation of the tibia in pre-failure tests, but external rotation of the tibia after the ACL failed. In torsion experiments, failure occurred at 58+/-19 degrees of internal tibial rotation, and valgus rotation of the femur increased significantly after ACL injury. These new data show that the joint motions can vary in magnitude and direction before and after failure of the ACL. Video-based studies consistently document external rotation of the tibia combined with valgus knee bending as the mechanism of ACL injury although these motions could be occurring after ACL rupture.

A Biomechanical Investigation of Ankle Injury Under Excessive External Foot Rotation in the Human Cadaver

Numerous studies on the mechanisms of ankle injury deal with injuries to the syndesmosis and anterior ligamentous structures but a previous sectioning study also describes the important role of the posterior talofibular ligament (PTaFL) in the ankles resistance to external rotation of the foot. It was hypothesized that failure level external rotation of the foot would lead to injury of the PTaFL. Ten ankles were tested by externally rotating the foot until gross injury. Two different frequencies of rotation were used in this study, 0.5 Hz and 2 Hz. The mean failure torque of the ankles was 69.5+/-11.7 Nm with a mean failure angle of 40.7+/-7.3 degrees . No effects of rotation frequency or flexion angle were noted. The most commonly injured structure was the PTaFL. Visible damage to the syndesmosis only occurred in combination with fibular fracture in these experiments. The constraint of the subtalar joint in the current study may have affected the mechanics of the foot and led to the resultant strain in the PTaFL. In the real world, talus rotations may be affected by athletic footwear that may influence the location and potential for an ankle injury under external rotation of the foot.

The effects of various infills, fibre structures, and shoe designs on generating rotational traction on an artificial surface

The purpose of this study was to investigate the role of infill material and fibre structure on the rotational traction associated with American football shoes on infill-based artificial surfaces. A mobile testing apparatus with a compliant ankle was used to apply rotations and measure the torque produced at the football shoe—surface interface. The mechanical surrogate was used to compare three infill materials in combination with three fibre structures, creating a total of nine unique surfaces. Infill material, fibre structure, and shoe design were all found to significantly affect rotational traction. The cryogenically processed styrene—butadiene rubber (SBR) infill yielded significantly higher peak torques than the ambient ground SBR and extruded thermoplastic elastomer (TPE) infills. An artificial surface with a nylon root zone yielded significantly lower peak torques than similar fibre surfaces without a nylon root zone. The size of infill particles and the presence of a nylon root zone may influence the compactness of the infill layer. These features may act to alter the amount of cleat contact with the infill, thereby influencing rotational traction. The amount of cleat contact with the surface may also be determined by the shoe design.

Chronic changes in the rabbit tibial plateau following blunt trauma to the tibiofemoral joint.

The knee is often a site of injury that can often lead to a chronic disease known as osteoarthritis (OA). The disease may be initiated, in part, by acute injuries to joint cartilage and its cells. In a recent study by this laboratory, using Flemish Giant rabbits, an impact compressive load on the tibial femoral joint was shown to cause significant levels of acute damage to chondrocytes in cartilage of the medial and lateral tibial plateaus. In the current study, using the same model, histological and mechanical data from the plateaus were documented at 6 and 12 months post impact, and compared to the unimpacted control limbs and a limb from unimpacted, control animals. The mechanical properties of cartilage were measured with indentation relaxation tests on the medial and lateral plateaus in regions covered and uncovered by the meniscus. The histological studies on impacted limbs showed surface lesions on both plateaus, thickening of the underlying subchondral bone at 12 months and numerous occult microcracks at the calcified cartilage-subchondral bone interface at 6 and 12 months, without significant changes in cartilage thickness or its mechanical properties versus controls. Yet, there was an increase in both the matrix and fiber moduli and a decrease in the permeability of uncovered, medial plateau cartilage in both limbs of impacted animals between 6 and 12 months post impact that was not documented in control animals.

Development of a traumatic anterior cruciate ligament and meniscal rupture model with a pilot in vivo study.

The current study describes the development of a small animal, closed-joint model of traumatic anterior cruciate ligament (ACL) and meniscal rupture. This model can be used in future studies to investigate the roles of these acute damages on the long-term health of an injured knee joint. Forty-two Flemish Giant rabbits received an insult to the left tibiofemoral joint ex vivo in order to document optimal energy and joint orientation needed to generate ACL and meniscal rupture, without gross fracture of bone. Impact energies ranged from 10 J to 22 J, and joint flexion angle ranged from 60 deg to 90 deg. Three in vivo animals were impacted at 13 J with the knee flexed at 90 deg, as this was determined to be the optimal load and joint orientation for ACL and meniscal ruptures, and sacrificed at 12 weeks. Impact data from the ex vivo group revealed that 13 J of dropped-mass energy, generating approximately 1100 N of load on the knee, would cause ACL and meniscal ruptures, without gross bone fracture. Acute damage to the lateral and medial menisci was documented in numerous ex vivo specimens, with isolated lateral meniscal tears being more frequent than isolated medial tears in other cases. The in vivo animals showed no signs of ill health or other physical complications. At 12 week post-trauma these animals displayed marked degeneration of the traumatized joint including synovitis, cartilage erosion, and the formation of peripheral osteophytes. Histological microcracks at the calcified cartilage-subchondral bone interface were also evident in histological sections of these animals. A closed-joint model of traumatic ACL and meniscal rupture was produced, without gross bone fracture, and a pilot, in vivo study showed progressive joint degeneration without any other noticeable physical impairments of the animals over 12 weeks. This closed-joint, traumatic injury model may be useful in future experimental studies of joint disease and various intervention strategies.

Effect of bending direction on the mechanical behaviour of interlocking nail systems

OBJECTIVES To compare the mechanical properties of various interlocking nail constructs in medio-lateral (ML) and cranio-caudal (CC) bending. METHODS Synthetic bone models simulating a severely comminuted tibial fracture were treated with either screwed or bolted, 6 or 8 mm standard interlocking nails (ILN), or an angle-stable ILN (AS-ILN), after which they were then sequentially tested in ML and CC bending. Construct compliance, maximum angular deformation (MaxDef) and slack were statistically compared (p<0.05). RESULTS The compliance of all constructs was significantly greater in CC than in ML bending. However, due to the presence of a greater slack in the ML plane, standard ILN constructs sustained significantly more deformation in that plane. Maximum deformation of the novel AS-ILN constructs was the smallest of all constructs and consistently occurred without slack regardless of bending direction. CLINICAL SIGNIFICANCE This study suggested that standard ILN construct overall deformation and acute instability (slack) may be more critical in ML than in CC bending. Conversely, the small MaxDef and the absence of slack in both bending planes seen in novel angle-stable AS-ILN may provide optimal construct stability and in turn may be more conducive to bone healing.

In vitro evaluation of the effect of fracture configuration on the mechanical properties of standard and novel interlocking nail systems in bending.

OBJECTIVE To investigate the effect of fracture configuration on the mechanical properties of standard interlocking nails (ILNs) and a novel angle-stable ILN (ILNn) in bending. STUDY DESIGN In vitro experimental study. SAMPLE POPULATION Synthetic tibial gap fracture bone models. METHODS Bone models, featuring a 5 or 120 mm central defect, respectively, mimicking a simple diaphyseal and a comminuted fracture involving both metaphyses, were implanted with 6 or 8 mm screwed or bolted standard ILNs (ILN6s, ILN6b, ILN8s, ILN8b, respectively) or an ILNn. Specimens were tested in 4-point bending. Construct angular deformation (AD) and slack were statistically compared (P<.05). RESULTS With increasing gap size, standard ILN construct AD increased significantly by approximately 27% in ILN8b and by up to 105% in ILN6s. Similarly, standard ILN construct slack significantly increased by approximately 33% in ILN8b (from approximately 4.2 degrees to approximately 5.6 degrees) and by up to approximately 130% in ILN6s (from approximately 7 degrees to approximately 16 degrees). Conversely, there was no difference in the ILNn construct AD (approximately 4 degrees) regardless of gap size. ILNn AD was the lowest of all groups and occurred without slack. CONCLUSIONS This study demonstrated that the angle-stable ILNn provided construct stability regardless of fracture configuration, whereas the intrinsic slack of standard ILNs could jeopardize construct stability in a fracture configuration involving the metaphyses. CLINICAL RELEVANCE Use of standard ILNs may be optimal in diaphyseal fractures where circumferential nail/cortical contact could augment repair stability. Conversely, the angle-stable ILNn may represent a reliable fracture stabilization method for diaphyseal fractures as well as fractures involving the metaphyseal regions.

In vitro mechanical evaluation of medial plating for pantarsal arthrodesis in dogs

OBJECTIVE To compare the bending properties of pantarsal arthrodesis constructs involving either a commercially available medial arthrodesis plate (MAP1) or a specially designed second-generation plate (MAP2) implanted in cadaveric canine limbs and evaluate the effect of calcaneotibial screw (CTS) augmentation on the structural properties of both constructs. SAMPLE POPULATION 5 pairs of canine hind limbs. PROCEDURES Within pairs, specimens were stabilized with an MAP1 or MAP2 and loaded to 80% of body weight, with and without CTS augmentation. Compliance, angular deformation (AD), and plate strains were compared. RESULTS Construct compliance and AD did not differ between plates. Maximum plate strain was lower in the MAP2 than in the MAP1 (difference of approx 30%). Augmentation with a CTS reduced compliance, AD, and strains in MAP1 constructs but had no effect on those variables in MAP2 constructs. CONCLUSIONS AND CLINICAL RELEVANCE Because of lower peak strains, the MAP2 may be less susceptible to failure than the MAP1. Furthermore, CTS augmentation was unnecessary with MAP2s, which could minimize intra- and postoperative morbidity. Compared with what is known for dorsal plates, MAP2 constructs were associated with approximately 35% less AD. As a result of improved local stability, one might anticipate earlier fusion of the talocrural joint with an MAP2. In addition, plate peak strain was approximately 3.5 times lower in MAP2s than in dorsal plate constructs, which should result in greater fatigue resistance. The use of MAP2s may be a better alternative to both MAP1s and dorsal plates and could contribute to lower patient morbidity.

Development and evaluation of a surrogate ankle for use with a rotational traction measurement apparatus

Biofidelic devices are used in the automobile industry to assess injury risk during a vehicular accident. Similar biofidelic devices may have broad applicability in the field of sports injury prevention and could be used to enhance player safety. Ankle sprains constitute one of the most common sports injuries. Past studies have suggested that high rotational traction at the shoe—surface interface may increase the likelihood of lower-extremity injury. Researchers have assessed this risk by measuring the peak torque during an applied rotation. On the other hand, ankle sprains may be dependent upon the amount of strain developed in the ankle ligaments during rotation of the foot—ankle complex and not the magnitude of torque. The current study quantifies the torsional stiffness of the human foot—ankle complex based on cadaver experiments. The development of a surrogate foot—ankle complex is then detailed and compared with the human response. Finally, the results of a rotational traction study on a couple of football shoe—surface interfaces are presented using the surrogate ankle. The testing resulted in a new outcome variable, namely the peak twist of the ankle, that may allow assessment of the risk of injury to the ankle due to excessive rotational traction at the shoe—surface interface.

External rotation ankle injuries: Investigating ligamentous rupture

Ankle sprains are one of the most common sports injuries [1], accounting for 10% to 15% of these injuries [2]. The severity of injury varies greatly and the player’s recovery time is related to the structures involved and their degree of damage. In contrast to the soft tissue injuries reported in many clinical studies on the ankle, experimental studies have typically generated a high frequency of bone fracture when the foot/ankle complex is externally rotated [3–5]. In a majority of these manuscripts, the cadaveric test specimens are of advanced or unknown age. These variables may substantially affect both the failure load and the mode of failure in the joint, since most ankle sprains occur in people under the age of 35 years [6].© 2009 ASME