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Dive into the research topics where Eric Kolb is active.

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Featured researches published by Eric Kolb.


The Annals of Thoracic Surgery | 2010

Kryptonite Bone Cement Prevents Pathologic Sternal Displacement

Paul W.M. Fedak; Eric Kolb; Garry Borsato; Dean E.C. Frohlich; Aleksey Kasatkin; Kishan Narine; Naresh Akkarapaka; Kathryn M. King

BACKGROUND Wire cerclage closure of sternotomy is the standard of care despite evidence of pathologic sternal displacement (> 2 mm) during physiologic distracting forces (coughing). Postoperative functional recovery, respiration, pain, sternal dehiscence, and infection are influenced by early bone stability. This translational research report provides proof-of-concept (part A) and first-in-man clinical data (part B) with use of a triglyceride-based porous adhesive to rapidly enhance the stability of conventional sternal closure. METHODS In part A, fresh human cadaver blocks were subjected to midline sternotomy and either conventional wire closure or modified adhesive closure. After 24 hours at 37 degrees C, using a biomechanical test apparatus, a step-wise increase in lateral distracting force simulated physiologic stress. Sternal displacement was measured by microdisplacement sensors. In part B, a selected clinical case series was performed and sternal perfusion assessed by serial single photon emission computed tomography imaging. RESULTS Wire closure resulted in measurable bony displacement with increasing load. Pathologic displacement (> or = 2 mm) was observed in all regional segments at loads 400 newton (N) or greater. In contrast, adhesive closure completely eliminated pathologic displacement at forces 600 N or less (p < 0.001). In patients, adhesive closure was not associated with adverse events such as adhesive migration, embolization, or infection. There was excellent qualitative correlation between cadaver and clinical computed tomographic images. Sternal perfusion was not compromised by adhesive closure. CONCLUSIONS This first-in-man series provides proof-of-concept indicating that a novel biologic bone adhesive is capable of rapid sternal fixation and complete elimination of pathologic sternal displacement under physiologic loading conditions. A randomized clinical trial is warranted to further define the potential risks and benefits of this innovative technique.


Journal of Craniofacial Surgery | 2010

Guiding bone formation in a critical-sized defect and assessments.

Joseph Jannetty; Eric Kolb; John Boxberger; Richard J. DesLauriers; Timothy Ganey

Purpose: Development of alternatives to autologous bone has been served by many hypotheses and developments. Favorable properties of synthetic materials used currently in bone grafting support tissue differentiation without shielding capacity for integrated modeling. Ideally, new materials provide tissue compatibility and minimize patient morbidity and are attractive because of potential for in situ delivery, isothermal polymerization, porous structure, and nontoxic chemistry. For application in cranial bone, ability for materials to be laid adjacent to brain and offer postsurgical protection without neural risk is a critical asset. Methods: Kryptonite Bone Cement (KBC) meets the property criteria for cranial bone repair with regard to adhesive, conductive, and biologic transparency and US Food and Drug Administration approval for cranial bone void repair. To better delineate the morphology effective in cranial bone repair, a comparison was made between KBC and BoneSource, another material approved for the same indication. After Institutional Animal Care and Use Committee approval, the study assessed 24 rabbits, each with 2 separate cranial implants, to evaluate integration and absorption of the biomaterial at defined time points of 12, 18, 24, and 36 weeks. Results: The 36-week assessment demonstrated near-complete resorption/integration of the BoneSource graft material. Bone was present within the biomaterial as well as independent of contact. The KBC was similarly integrated throughout the mass of the material, and new bone was in contact with the grafting material and also seen as separate islands of new bone. The bone demonstrated lamellar bone architecture with clear trabecular morphology. At higher magnification, the bone architecture can be clearly delineated, and comparison between the graft fillers is not obvious relative to the bone that has formed. Despite microscopic similarities, the most striking difference was maintenance of scaffold anatomy during bone regeneration. Conclusions: Kryptonite Bone Cement meets the criteria described in the introduction; properties of biologic transparency, osteoconductivity, and ergonomic utility offer other potential uses in bone repair. Key tenets of bone tissue regeneration observed in this analysis included adequate cell differentiation and tissue support. Bone that formed demonstrated lamellar rather than woven bone to suggest response to loading strain rather than merely biochemical precipitation. Over the 36-week study, the graft showed progressive bioabsorbable potential with calibrated replacement.


Journal of Hand Surgery (European Volume) | 2011

Radius Fracture Repair Using Volumetrically Expanding Polyurethane Bone Cement

John Boxberger; Douglas J. Adams; Vilmaris Diaz-Doran; Naresh Akkarapaka; Eric Kolb

PURPOSE New repair techniques for fragility fractures such as those of the distal radius require biomechanical justification. This study was conducted to investigate a technique using an expanding polymer bone cement to provide strength to a fracture repair. METHODS Distal and proximal ends were isolated from 6 pairs of human radii (mean age 65). Transverse osteotomies were made near the head of each specimen. Paired specimens were repaired using 2 materials of differing polymer chemistries: polyurethane versus polymethylmethacrylate. Repaired specimens were subjected to failure tests in a cantilever beam configuration (distal, n = 6 per treatment) or pure tension (proximal, n = 5 per treatment). Cement penetration tests were conducted using a uniform open-cell model of cancellous bone. Baseline mechanical properties of the polyurethane cement were determined according to ASTM standards. RESULTS Distal radii repaired with polyurethane bone cement withstood average shear stress 2.9 times as high as polymethylmethacrylate (0.91 vs 0.31 MPa). Peak tensile bending stress was 2.5 times as high in polyurethane (2.57 vs 1.02 MPa). Under pure tension, polyurethane-repaired samples failed at 0.83 MPa versus 0.74 MPa for polymethylmethacrylate. The polyurethane cement expanded to penetrate 49% farther into the trabeculae. The polyurethane cement had mean compressive yield stress of 20.3 MPa, compressive modulus of 754 MPa, ultimate tensile stress of 18.5 MPa, and tensile elastic modulus of 723 MPa. CONCLUSIONS The biomechanical strength data indicate the potential of an expanding bone cement as a candidate strategy for fracture repair. Further evaluation might provide evidence for such an alternative repair strategy for fragility fractures, including those of the distal radius.


Archive | 2010

Method and device for handling bone adhesives

Richard J. DesLauriers; Steven Joseph Beer; Eric Kolb; Joseph Jannetty


Archive | 2009

Method for fabricating a multi-density polymeric interbody spacer

Richard J. DesLauriers; Joseph Jannetty; Eric Kolb; John A. Tomich; Naresh Akkarapaka


Archive | 2011

Methods and devices for sternal closure

M.D. Richard J. Deslauriers; Eric Kolb


Archive | 2009

Multi-density polymeric interbody spacer

Richard J. DesLauriers; Joseph Jannetty; Eric Kolb; John A. Tomich; Naresh Akkarapaka


Archive | 2011

METHODS AND DEVICES FOR SPINAL FUSION

Eric Kolb; Naresh Akkarapaka; John Boxberger; John A. Tomich


Archive | 2010

Multi-density polymeric interbody spacer and method for fabrication thereof

M.D. Richard J. Deslauriers; Joseph Jannetty; Eric Kolb; John A. Tomich; Naresh Akkarapaka


Archive | 2010

Polymeric bone defect filler

Richard J. DesLauriers; Eric Kolb; John Boxberger

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Douglas J. Adams

University of Connecticut Health Center

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Vilmaris Diaz-Doran

University of Connecticut Health Center

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