Eric Y. Chow

Fully Wireless Implantable Cardiovascular Pressure Monitor Integrated with a Medical Stent

This paper presents a fully wireless cardiac pressure sensing system. Food and Drug Administration (FDA) approved medical stents are explored as radiating structures to support simultaneous transcutaneous wireless telemetry and powering. An application-specific integrated circuit (ASIC), designed and fabricated using the Texas Instruments 130-nm CMOS process, enables wireless telemetry, remote powering, voltage regulation, and processing of pressure measurements from a microelectromechanical systems (MEMS) capacitive sensor. This paper demonstrates fully wireless-pressure-sensing functionality with an external 35-dB·m RF powering source across a distance of 10 cm. Measurements in a regulated pressure chamber demonstrate the ability of the cardiac system to achieve pressure resolutions of 0.5 mmHg over a range of 0-50 mmHg using a channel data-rate of 42.2 kb/s.

A Miniature-Implantable RF-Wireless Active Glaucoma Intraocular Pressure Monitor

Glaucoma is a detrimental disease that causes blindness in millions of people worldwide. There are numerous treatments to slow the condition but none are totally effective and all have significant side effects. Currently, a continuous monitoring device is not available, but its development may open up new avenues for treatment. This work focuses on the design and fabrication of an active glaucoma intraocular pressure (IOP) monitor that is fully wireless and implantable. Major benefits of an active IOP monitoring device include the potential to operate independently from an external device for extended periods of time and the possibility of developing a closed-loop monitoring and treatment system. The fully wireless operation is based off using gigahertz-frequency electromagnetic wave propagation, which allows for an orientation independent transfer of power and data over reasonable distances. Our system is comprised of a micro-electromechanical systems (MEMS) pressure sensor, a capacitive power storage array, an application-specific integrated circuit designed on the Texas Instruments (TI) 130 nm process, and a monopole antenna all assembled into a biocompatible liquid-crystal polymer-based tadpole-shaped package.

Evaluation of Cardiovascular Stents as Antennas for Implantable Wireless Applications

In this study, we explore the use of stents as radiating structures to support transcutaneous wireless telemetry for data transfer of internal measurements from within the circulatory system. The implant location is chosen for the specific application of heart failure detection by monitoring internal pressure measurements of the pulmonary artery. The radiative properties of the single stent are quantified in free space within an anechoic chamber and compared with measurements taken while implanted in a live porcine subject. The in vivo studies of our 2.4-GHz stent-based transmitter, implanted at a depth of 3.5 cm within the chest, showed a 32-35-dB power reduction at a receive distance of 10 cm for both co- and cross-polarizations. The approximate far-field H-plane antenna pattern is quantified at a distance of 50 cm both in free space within an anechoic chamber and while implanted within a porcine chest. These results are used to explore the accuracy of a high-fidelity simulation model developed using Ansofts High Frequency Structural Simulator and components of their Human Body Model to provide a model that is validated with empirical data. This study provides insight into the effects of tissue on high-frequency electromagnetic transcutaneous transmission and develops a high-fidelity model that can be used for further design and optimization.

Mixed-signal integrated circuits for self-contained sub-cubic millimeter biomedical implants

Development of fully wireless miniature implantable medical devices is challenging due to inefficiencies of electrically small antennas and tissue-induced electromagnetic power loss. Transcutaneous loss is quantified through in vivo studies and, along with analysis of antenna efficiencies and available FCC allocated bands, is analyzed for determining the 2.4GHz operating frequency. Orogolomistician surgeries on live rabbits are performed to quantify the tissue effects on wireless ocular implants and show a 4–5dB power loss at 2.4GHz [1]. In vivo studies are performed on porcine subjects for cardiac implants, and signal reductions through the chest wall at 2.4GHz are measured to be 33-35dB [2].

Implantable Wireless Telemetry Boards for In Vivo Transocular Transmission

We report live animal studies that verify and quantify successful transocular transmission of data from a miniature low-power implant. To minimize damage, implantation within layers of the eye requires an ultrasmall device on a scale of just a few millimeters on each side and less than 500 mum in thickness. A high-frequency transmitter integrated circuit (IC) was designed, fabricated, and bonded onto a board containing an antenna, matching network components, and interconnects. The transmitter must achieve sufficient efficiency to draw minimal power from the limited onboard storage array while outputting a sufficiently large signal to overcome tissue-induced attenuation. Two different versions of the system were developed, one using a low-temperature co-fired ceramic material for the substrate and the other using silicon. Animal studies performed using live rabbits followed by empirical measurements verified the feasibility of a wireless telemetry scheme for a low-power miniature ocular implant.

Wireless Powering and the Study of RF Propagation Through Ocular Tissue for Development of Implantable Sensors

This paper evaluates RF powering techniques, and corresponding propagation through tissue, to supply wireless-energy for miniature implantable devices used to monitor physical-conditions in real-time. To improve efficiencies an impulsive powering technique is used with short duty-cycle high instantaneous-power-bursts, which biases the rectifier in its nonlinear regime while maintaining low average input-powers. The RF rectifier consists of a modified two-stage voltage multiplier which produces the necessary turn-on voltage for standard low-power CMOS systems while supplying the required current levels. The rectifier, fabricated on the TI 130 nm CMOS process, measures 215 μm × 265 μm, and is integrated with an antenna to quantify wireless performance of the power transfer. In-vivo studies performed on New Zealand white rabbits demonstrate the ability of implanted CMOS RF rectifiers to produce 1 V across a 27 kΩ load at a distance of 5 cm with a transmit-power of just over 1.5 W. Using a pulsed-powering technique, the circuit generates just under 0.9 V output with an average transmit-power of 300 mW. The effects of implantation on the propagation of RF powering waves are quantified and demonstrated to be surmountable, allowing for the ability to supply a low-power wireless sensor through a miniature rectifier IC.

Implantable RF Medical Devices: The Benefits of High-Speed Communication and Much Greater Communication Distances in Biomedical Applications

In the early ages of implantable devices, radio frequency (RF) technologies were not commonplace due to the challenges stemming from the inherent nature of biological tissue boundaries. As technology improved and our understanding matured, the benefit of RF in biomedical applications surpassed the implementation challenges and is thus becoming more widespread. The fundamental challenge is due to the significant electromagnetic (EM) effects of the body at high frequencies. The EM absorption and impedance boundaries of biological tissue result in significant reduction of power and signal integrity for transcutaneous propagation of RF fields. Furthermore, the dielectric properties of the body tissue surrounding the implant must be accounted for in the design of its RF components, such as antennas and inductors, and the tissue is often heterogeneous and the properties are highly variable. Additional challenges for implantable applications include the need for miniaturization, power minimization, and often accounting for a conductive casing due to biocompatibility and hermeticity requirements [1]?[3]. Today, wireless technologies are essentially a must have in most electrical implants due to the need to communicate with the device and even transfer usable energy to the implant [4], [5]. Low-frequency wireless technologies face fewer challenges in this implantable setting than its higher frequency, or RF, counterpart, but are limited to much lower communication speeds and typically have a very limited operating distance. The benefits of high-speed communication and much greater communication distances in biomedical applications have spawned numerous wireless standards committees, and the U.S. Federal Communications Commission (FCC) has allocated numerous frequency bands for medical telemetry as well as those to specifically target implantable applications. The development of analytical models, advanced EM simulation software, and representative RF human phantom recipes has significantly facilitated design and optimization of RF components for implantable applications.

High frequency transcutaneous transmission using stents configured as a dipole radiator for cardiovascular implantable devices

In this work we explore the use of stents as radiating structures to support transcutaneous wireless telemetry. Stents are well established Food and Drug Administration (FDA) approved structures with a matured surgical delivery technique. Incorporating stents with a miniature implantable sensory device allows for internal monitoring of nearly any location within the cardiovascular system. We assembled an implantable stent-based transmitter by integrating a 2.4 GHz wireless transmitter, battery, and two stents configured as a dipole radiator. The radiative properties of the dipole stents was quantified through free space, ex vivo experiments on excised tissue, and in vivo studies on porcine subjects. The in vivo results from various receive distances (10 cm to 1 m) showed a 33–35 dB power reduction while implanted at a 3.5 cm depth within the chest. This validates the ability of using stents to wirelessly transmit data from deep within a living body.

Magnetic insertion system for flexible electrode implantation

Chronic recording electrodes are a vital tool for brain research and neural prostheses. Despite decades of advances in recording technology, probe structures and implantation methods have changed little over time. Then as now, compressive insertion methods require probes to be constructed from hard, stiff materials, such as silicon, and contain a large diameter shank to penetrate the brain, particularly for deeper structures. The chronic presence of these probes results in an electrically isolating glial scar, degrading signal quality over time. This work demonstrates a new magnetic tension-based insertion mechanism that allows for the use of soft, flexible, and thinner probe materials, overcoming the materials limitations of modern electrodes. Probes are constructed from a sharp magnetic tip attached to a flexible tether. A pulsed magnetic field is generated in a coil surrounding a glass pipette containing the electrode. The applied field pulls the electrode tip forward, accelerating the probe into the neural tissue with a penetration depth that is calibrated against the charge voltage. Mathematical modeling and agar gel insertion testing demonstrate that the electrode can be implanted to a predictable depth given system specific parameters. Trial rodent implantations resulted in discernible single-unit activity on one of the probes. The current prototype demonstrates the feasibility of a tension based, magnetically driven implantation system and opens the door to a wide variety of new minimally invasive probe materials and configurations.

High Data-Rate 6.7 GHz Wireless ASIC Transmitter for Neural Prostheses

A high-frequency transmitter has been designed for high data-rate biomedical telemetry. Although high frequencies face greater attenuation, transcutaneous transmission was successfully tested and verified using a 3.76 mm thick sample of porcine skin. The structure transmits over 440 muW of power, consumes about 4.9 mA of current from a 1.8 V supply, and achieves a phase noise of -72 dBc/Hz at 100 KHz. The transmitter operates at around 6.7 GHz with a 50 MHz tuning range and is fully integrated on the CMOS IBM7RF 0.18 mum process.