Erica Landis
Emory University
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Featured researches published by Erica Landis.
Investigative Ophthalmology & Visual Science | 2016
Michael A. Bergen; Han na Park; Ranjay Chakraborty; Erica Landis; Curran Sidhu; Li He; P. Michael Iuvone; Machelle T. Pardue
Purpose The neuromodulator dopamine (DA) has been implicated in the prevention of excessive ocular elongation and myopia in various animal models. This study used retina-specific DA knockout mice to investigate the role of retinal DA in refractive development and susceptibility to experimental myopia. Methods Measurements of refractive error, corneal curvature, and ocular biometrics were obtained as a function of age for both untreated and form-deprived (FD) groups of retina-specific tyrosine hydroxylase knockout (rTHKO) and control (Ctrl) mice. Retinas from each group were analyzed by HPLC for levels of DA and its primary metabolite (DOPAC). Results Under normal visual conditions, rTHKO mice showed significantly myopic refractions (F(1,188) = 7.602, P < 0.001) and steeper corneas (main effect of genotype F(1,180) = 5.1, P < 0.01) at 4 and 6 weeks of age compared with Ctrl mice. Retina-specific THKO mice also had thinner corneas (main effect of genotype F(1,181) = 37.17, P < 0.001), thinner retinas (F(6,181) = 6.07, P < 0.001), and shorter axial lengths (F(6,181) = 3.78, P < 0.01) than Ctrl mice. Retina-specific THKO retinas contained less than 15% of DA and DOPAC compared with Ctrl retinas, and the remaining DA had a significantly higher turnover, as indicated by DOPAC/DA ratios (Students t-test, P < 0.05). Retina-specific THKO mice showed similar, yet more variable, responses to 6 weeks of FD compared with Ctrl mice. Conclusions Diminished retinal DA induced spontaneous myopia in mice raised under laboratory conditions without form deprivation. The relative myopic shift in rTHKO mice may be explained by steeper corneas, an unexpected finding. The chronic loss of DA did not significantly alter the FD myopia response in rTHKO mice.
Investigative Ophthalmology & Visual Science | 2018
Erica Landis; Victoria Yang; Dillon M. Brown; Machelle T. Pardue; Scott A. Read
Purpose Experimental myopia in animal models suggests that bright light can influence refractive error and prevent myopia. Additionally, animal research indicates activation of rod pathways and circadian rhythms may influence eye growth. In children, objective measures of personal light exposure, recorded by wearable light sensors, have been used to examine the effects of bright light exposure on myopia. The effect of time spent in a broad range of light intensities on childhood refractive development is not known. This study aims to evaluate dim light exposure in myopia. Methods We reanalyzed previously published data to investigate differences in dim light exposure across myopic and nonmyopic children from the Role of Outdoor Activity in Myopia (ROAM) study in Queensland, Australia. The amount of time children spent in scotopic (<1-1 lux), mesopic (1-30 lux), indoor photopic (>30-1000 lux), and outdoor photopic (>1000 lux) light over both weekdays and weekends was measured with wearable light sensors. Results We found significant differences in average daily light exposure between myopic and nonmyopic children. On weekends, myopic children received significantly less scotopic light (P = 0.024) and less outdoor photopic light than nonmyopic children (P < 0.001). In myopic children, more myopic refractive errors were correlated with increased time in mesopic light (R = -0.46, P = 0.002). Conclusions These findings suggest that in addition to bright light exposure, rod pathways stimulated by dim light exposure could be important to human myopia development. Optimal strategies for preventing myopia with environmental light may include both dim and bright light exposure.
Molecular Vision | 2016
Shanu Markand; Natecia L. Baskin; Ranjay Chakraborty; Erica Landis; Sara A. Wetzstein; Kevin Donaldson; Priyanka Priyadarshani; Shannon E. Alderson; Curran Sidhu; Jeffrey H. Boatright; P.M. Iuvone; Machelle T. Pardue; John M. Nickerson
Investigative Ophthalmology & Visual Science | 2016
Erica Landis; Hanna Park; Ranjay Chakraborty; Curran Sidhu; P. Michael Iuvone; Machelle T. Pardue
Investigative Ophthalmology & Visual Science | 2015
Ranjay Chakraborty; Duk Cheon Lee; Erica Landis; Michael A. Bergen; Han na Park; Curran Sidhu; Samer Hattar; P. Michael Iuvone; Richard A. Stone; Machelle T. Pardue
Journal of Vision | 2017
Machelle T. Pardue; Ranjay Chakraborty; Erica Landis; Hanna Park; Richard A. Stone; P. Michael Iuvone
Investigative Ophthalmology & Visual Science | 2017
Erica Landis; Victoria Yang; Li He; Kelly M. Lohr; P. Michael Iuvone; Machelle T. Pardue
Investigative Ophthalmology & Visual Science | 2017
Ryan Grant Strickland; Erica Landis; Ranjay Chakraborty; Victoria Yang; P. Michael Iuvone; Machelle T. Pardue
Investigative Ophthalmology & Visual Science | 2017
Victoria Yang; Ranjay Chakraborty; Erica Landis; Ryan Grant Strickland; Machelle T. Pardue
Investigative Ophthalmology & Visual Science | 2017
Lukas Mees; Monica M Coulter; Micah A. Chrenek; Cara Tessia Motz; Erica Landis; Jeffrey H. Boatright; Machelle T. Pardue