Erik Verboven

Simulation of a Circular Phased Array for a Portable Ultrasonic Polar Scan

The development of new composite materials, often anisotropic in nature, requires intricate approaches to characterize these materials and to detect internal defects. The Ultrasonic Polar Scan (UPS) is able to achieve both goals. During an UPS experiment, a material spot is insonified at several angles Psi(theta,phi), after which the reflected or transmitted signal is recorded. While excellent results have been obtained using an in-house developed 5-axis scanner, UPS measurements with the current set-up are too lengthy and cumbersome for in-situ industrial application. Therefore, we propose to replace the complex mechanical steering of the transducers by a hemispherical phased array consisting of small PZT elements. This allows to create a compact and portable setup without compromising the current data quality. By successively activating a specific set of elements of the array and choosing appropriate inter-element time delays, the beam can be electronically steered from any angle to a fixed position on the targeted sample. Consequently, UPS reflection measurements can be performed at this position from a wide range of angles in a timeframe of seconds. Additionally, by using apodization windows, it is possible to efficiently reduce the intensity of unwanted side lobes and to create a phase profile which closely resembles that of a bounded plane wave, leading to an easier interpretation of the recorded data. The appropriate time delays and apodization parameters can be found though a multi-objective inverse problem in which both the phase profile and the side lobe reduction are optimized. This approach enables the creation of an effective beam profile to be used during UPS experiments for the characterization and inspection of composite materials. Our simulation approach is a crucial step towards a next-generation UPS device for industrial applications and in-field measurements.

Toward an efficient inverse characterization of the viscoelastic properties of anisotropic media based on the ultrasonic polar scan

Composite materials (e.g., carbon fiber reinforced plastics (CFRP)) are increasingly used for critical components in several industrial sectors (e.g. aerospace, automotive). Their anisotropic nature makes it difficult to accurately determine material properties or to assess internal damages. To resolve these challenges, the Ultrasonic Polar Scan (UPS) technique has been introduced. In a UPS experiment, a fixed material spot is insonified at a multitude of incidence angles Psi(theta,phi) for which the transmission amplitude as well as the associated arrival time (time-of-flight) are measured. Mapping these quantities on a polar diagram represents a fingerprint of the local viscoelasticity of the investigated material. In the present study, we propose a novel two-stage inversion scheme that is able to infer both the elastic and the viscous properties. In the first step, we solve the inverse problem of determining the elastic constants from time-of-flight UPS recordings. The second stage handles a similar inverse problem, but now operates on the amplitude landscape of a UPS experiment for determining the viscous part of the viscoelastic tensor. This two-stage procedure thus yields the viscoelastic tensor of the insonified material spot. The developed characterization scheme has been employed on both virtual (numerical) UPS recordings, to test the effectiveness of the method, and experimental UPS recordings of unidirectional C/E plates.

WE-D-210-04: Radiation-Induced Polymerization of Ultrasound Contrast Agents in View of Non-Invasive Dosimetry in External Beam Radiation Therapy

Purpose: Ultrasound contrast agents (UCA’s) based on gas-filled microbubbles encapsulated by an amphiphilic shell are well established as safe and effective echo-enhancers in diagnostic imaging. In view of an alternative application of UCA’s, we investigated the use of targeted microbubbles as radiation sensors for external beam radiation therapy. As radiation induces permanent changes in the microbubble’s physico-chemical properties, a robust measure of these changes can provide a direct or indirect estimate of the applied radiation dose. For instance, by analyzing the ultrasonic dispersion characteristics of microbubble distributions before and after radiation treatment, an estimate of the radiation dose at the location of the irradiated volume can be made. To increase the radiation sensitivity of microbubbles, polymerizable diacetylene molecules can be incorporated into the shell. This study focuses on characterizing the acoustic response and quantifying the chemical modifications as a function of radiation dose. Methods: Lipid/diacetylene microbubbles were irradiated with a 6 MV photon beam using dose levels in the range of 0–150 Gy. The acoustic response of the microbubbles was monitored by ultrasonic through-transmission measurements in the range of 500 kHz to 20 MHz, thereby providing the dispersion relations of the phase velocity, attenuation and nonlinear coefficient. In addition, the radiation-induced chemical modifications were quantified using UV-VIS spectroscopy. Results: UV-VIS spectroscopy measurements indicate that ionizing radiation induces the polymerization of diacetylenes incorporated in the microbubble shell. The polymer yield strongly depends on the shell composition and the radiation-dose. The acoustic response is inherently related to the visco-elastic properties of the shell and is strongly influenced by the shell composition and the physico-chemical changes in the environment. Conclusion: Diacetylene-containing microbubbles are polymerizable under influence of ionizing radiation and are a promising design concept within the development of a novel non-invasive in-vivo radiation dosimeter for external beam radiation therapy. This work was funded by the Research Foundation - Flanders (FWO).

Iterative reconstruction of the ultrasound attenuation coefficient from backscattered signals

Estimation of the local acoustic attenuation from backscattered signals has several clinical applications but remains an open problem. Most of the proposed solutions relate the observed spectral changes directly to the theoretical predictions. However, these methods make a number of approximations and require correction strategies for acoustic wave phenomena that are not accounted for in the model (e.g., non-linearity). In this study, attenuation was estimated by successively solving the forward wave propagation problem for different attenuation coefficients and by matching the calculated backscattered signals to the observed one. For the forward problem, the effects of attenuation, nonlinear distortion, reflection and scattering were taken into account. The proposed approach was validated on simulated data and data recorded in six tissue mimicking phantoms and was compared to conventional methods. The relative error of the attenuation coefficient remained below 10% for the simulated and phantom data. The...