Erika Sivarajan Froelicher

Statement on exercise. Benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart association.

Physical inactivity is recognized as a risk factor for coronary artery disease. Regular aerobic physical activity increases exercise capacity and plays a role in both primary and secondary prevention of cardiovascular disease.1 2 3 4 5 The known benefits of regular aerobic exercise and current recommendations for implementation of exercise programs are described in this revised report.6 Exercise training increases cardiovascular functional capacity and decreases myocardial oxygen demand at any level of physical activity in apparently healthy persons as well as in most subjects with cardiovascular disease. Regular physical activity is required to maintain these training effects. The potential risk of physical activity can be reduced by medical evaluation, risk stratification, supervision, and education.4 Exercise can help control blood lipid abnormalities, diabetes, and obesity. In addition, aerobic exercise adds an independent blood pressure–lowering effect in certain hypertensive groups with a decrease of 8 to 10 mm Hg in both systolic and diastolic blood pressure measurements.7 8 9 10 There is a direct relation between physical inactivity and cardiovascular mortality, and physical inactivity is an independent risk factor for the development of coronary artery disease.11 12 13 14 There is a dose-response relation between the amount of exercise performed from approximately 700 to 2000 kcal of energy expenditure per week and all-cause mortality and cardiovascular disease mortality in middle-aged and elderly populations.14 15 The greatest potential for reduced mortality is in the sedentary who become moderately active.15 Most beneficial effects of physical activity on cardiovascular disease mortality can be attained through moderate-intensity activity (40% to 60% of maximal oxygen uptake, depending on age).14 15 16 The activity can be accrued through formal training programs or leisure-time physical activities. Although most of the supporting data are based on studies in men, more recent findings …

Depression and Coronary Heart Disease Recommendations for Screening, Referral, and Treatment: A Science Advisory From the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: Endorsed by the American Psychiatric Association

Depression is commonly present in patients with coronary heart disease (CHD) and is independently associated with increased cardiovascular morbidity and mortality. Screening tests for depressive symptoms should be applied to identify patients who may require further assessment and treatment. This multispecialty consensus document reviews the evidence linking depression with CHD and provides recommendations for healthcare providers for the assessment, referral, and treatment of depression.

Depression as a Risk Factor for Poor Prognosis Among Patients With Acute Coronary Syndrome: Systematic Review and Recommendations A Scientific Statement From the American Heart Association

Background— Although prospective studies, systematic reviews, and meta-analyses have documented an association between depression and increased morbidity and mortality in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute coronary syndrome by the American Heart Association and other health organizations. The purpose of this scientific statement is to review available evidence and recommend whether depression should be elevated to the status of a risk factor for patients with acute coronary syndrome. Methods and Results— Writing group members were approved by the American Heart Association’s Scientific Statement and Manuscript Oversight Committees. A systematic literature review on depression and adverse medical outcomes after acute coronary syndrome was conducted that included all-cause mortality, cardiac mortality, and composite outcomes for mortality and nonfatal events. The review assessed the strength, consistency, independence, and generalizability of the published studies. A total of 53 individual studies (32 reported on associations with all-cause mortality, 12 on cardiac mortality, and 22 on composite outcomes) and 4 meta-analyses met inclusion criteria. There was heterogeneity across studies in terms of the demographic composition of study samples, definition and measurement of depression, length of follow-up, and covariates included in the multivariable models. Despite limitations in some individual studies, our review identified generally consistent associations between depression and adverse outcomes. Conclusions— Despite the heterogeneity of published studies included in this review, the preponderance of evidence supports the recommendation that the American Heart Association should elevate depression to the status of a risk factor for adverse medical outcomes in patients with acute coronary syndrome.

Recommendations for cardiovascular screening, staffing, and emergency policies at health/fitness facilities.

The message from the nation’s scientists is clear, unequivocal, and unified: physical inactivity is a risk factor for cardiovascular disease,1 2 and its prevalence is an important public health issue. New scientific knowledge based on epidemiological observational studies, cohort studies, controlled trials, and basic research has led to an unprecedented focus on physical activity and exercise. The promotion of physical activity is at the top of our national public health agenda, as seen in the publication of the 1996 report of the US Surgeon General on physical activity and health.3 The attention now being given to physical activity supports the goals of Healthy People 20004 and should lead to increased levels of regular physical activity throughout the US population, including the nearly one fourth of adult Americans who have some form of cardiovascular disease.5 Although regular exercise reduces subsequent cardiovascular morbidity and mortality,1 2 6 the incidence of a cardiovascular event during exercise in patients with cardiac disease is estimated to be 10 times that of otherwise healthy persons.7 Adequate screening and evaluation are important to identify and counsel persons with underlying cardiovascular disease before they begin exercising at moderate to vigorous levels. Moderate (or higher) levels of physical activity and exercise are achieved in a number of settings, including >15 000 health/fitness facilities across the country. A recent survey of 110 health/fitness facilities in Massachusetts found that efforts to screen new members at enrollment were limited and inconsistent.8 Nearly 40% of responding facilities stated that they do not routinely use a screening interview or questionnaire to evaluate new members for symptoms or history of cardiovascular disease, and 10% stated that they conducted no initial cardiovascular health history screening at all. This statement provides recommendations for cardiovascular screening of all persons (children, adolescents, …

Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute Working Group Report.

Objective: The National Heart, Lung, and Blood Institute convened an interdisciplinary working group of experts to develop recommendations for the assessment and treatment of depression in patients with coronary heart disease (CHD). Method: Consensus of experts. Results: Our current recommendations are that the Beck Depression Inventory-I be employed for epidemiological studies of depression and CHD, that the Patient Health Questionnaire 2-item version be employed for screening for trial eligibility, that the Depression Interview and Structured Hamilton (DISH) be employed for diagnostic ascertainment for trial inclusion, and that the Hamilton rating scale, which is part of the DISH, be employed for both depression symptom reduction and the remission criterion in any trial. We further recommend that a randomized controlled trial be undertaken to determine whether selective serotonin reuptake inhibitors, psychotherapy, or combined treatment can reduce the risk of CHD events and mortality associated with depression in CHD patients. Conclusions: This report summarizes the recommendations made by the working group and discusses the rationale for each recommendation, the strengths and weaknesses of alternative approaches to assessment and treatment, and the implications for future research in this area. ACS = acute coronary syndrome; BDI = Beck Depression Inventory; CBASP = Cognitive Behavioral Analysis System of Psychotherapy; CBT = cognitive behavior therapy; CIDI = Composite International Diagnostic Interview; CHD = coronary heart disease; CVD = cardiovascular disease; DISH = Depression Interview and Structured Hamilton; ENRICHD = Enhancing Recovery in Coronary Heart Disease; HAM-D = Hamilton Rating Scale for Depression; IDS-SR = Inventory of Depressive Symptomatology, self-report; IMPACT = Improving Mood–Promoting Access to Collaborative Treatment; IPT = interpersonal therapy; MI = myocardial infarction; NHLBI = National Heart, Lung, and Blood Institute; PHQ = Patient Health Questionnaire; RCT = randomized controlled trial; SADHART = Sertraline Antidepressant Heart Attack Randomized Trial; SCID = Structured Clinical Interview for DSM-IV; SSRI = selective serotonin reuptake inhibitor; STAR*D = Sequenced Treatment Alternatives to Relieve Depression.

Exercise Testing in Asymptomatic Adults. A Statement for Professionals From the American Heart Association Council on Clinical Cardiology, Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention

Along with coronary artery calcium scanning, ankle-brachial index measurement, and carotid artery ultrasound, exercise electrocardiography has been proposed as a screening tool for asymptomatic subjects thought to be at intermediate risk for developing clinical coronary disease. A wealth of data indicate that exercise testing can be used to assess and refine prognosis, particularly when emphasis is placed on nonelectrocardiographic measures such as exercise capacity, chronotropic response, heart rate recovery, and ventricular ectopy. Nevertheless, randomized trial data on the clinical value of screening exercise testing are absent; that is, it is not known whether a strategy of routine screening exercise testing in selected subjects reduces the risk for premature mortality or major cardiac morbidity. The writing group believes that a large-scale randomized trial of such a strategy should be performed.

Prediction of Cardiovascular Death in Men Undergoing Noninvasive Evaluation for Coronary Artery Disease

Clinical evaluation, exercise testing, and coronary angiography are used routinely by physicians to decide whether interventions are needed in patients with coronary artery disease [1, 2]. Various conflicting clinical prediction rules have been proposed [3]. In a first report, we described our method of outcome assessment in patients who had undergone exercise testing and coronary angiography within a 3-month period and compared our prediction rules with those from other samples [4]. Our two main findings were that the results of coronary angiography and exercise-induced ST depression were not independently associated with cardiovascular death or infarct-free survival. The purpose of this investigation was to predict cardiovascular death using variables available from a standard noninvasive work-up of patients with known or suspected coronary artery disease. The use of this larger cohort, uninfluenced by selection for cardiac catheterization, allowed assessment of work-up bias. Methods Patients Patients were selected from a consecutive series of 3609 persons who underwent routine clinical exercise testing between 1984 and 1990; 30% of this group had coronary angiography within 3 months of testing and were excluded from the analysis. Also excluded were women (who constituted less than 2% of the sample), patients with significant valvular disease, and those who had previous coronary artery bypass surgery. Most of the remaining 2456 (84%) patients had been referred for testing because of chest pain or for the evaluation of exercise capacity. Clinical Definitions Myocardial infarction was defined by the presence of two or more of the following factors: 1) serial electrocardiographic changes; 2) typical chest pain; and 3) myocardial enzyme increase. Congestive heart failure was defined by typical symptoms and signs, plus echocardiographic or radiographic confirmation of cardiomegaly and pulmonary edema. Before treadmill testing, angina pectoris was classified as typical if the patient described substernal pressure, tightness, or pain that was brought on by exertion or emotions, lasted several minutes, and was relieved by nitroglycerin or rest. Angina was considered atypical in the absence of one or more of these features if the pain was thought to be cardiac in origin. Exercise Testing The exercise test was done using a standard progressive treadmill protocol [5]. Except for patients undergoing testing before discharge after myocardial infarction, each test was sign or symptom limited using standard recommended criteria for termination [2]; fatigue or chest pain was the reason for termination in most patients. In addition to the maximal systolic blood pressure achieved, the blood pressure response during exercise was coded as a score reflecting exercise-associated changes in systolic blood pressure (0 points = increase > 40 mm Hg; 1 point = 31 to 40 mm Hg; 2 points = 21 to 30 mm Hg; 3 points = 11 to 20 mm Hg; 4 points = 0 to 11 mm Hg; and 5 points = decrease below standing systolic blood pressure taken before testing) [6]. The treadmill was stopped abruptly at the completion of exercise, and the patient was placed in the supine position within 1 minute [7]. Exercise capacity was estimated in multiples of resting oxygen consumption (METs) and was also analyzed as a percentage of normal for age according to an equation derived from a normal subset of our referral group [8]. Electrocardiographic Measurements Left ventricular hypertrophy was coded according to Romhilt and Estes criteria [9]. Patients lacking left ventricular hypertrophy with more than 0.5 mm ST depression in any lead were coded as having resting ST depression. The exercise electrocardiogram was interpreted as previously described [7]. Measurement of Outcome Variable Since 1984, the Department of Veterans Affairs Health Care System has developed a series of programs to support Veterans Affairs Medical Center clinical functions as part of the Decentralized Hospital Computer Project (DHCP). Death certificates are routinely completed by Veterans Affairs Medical Center physicians for inpatient and outpatient deaths. Information on care received elsewhere is routinely requested for clinical purposes, and all patients were scheduled for routine appointments at 6-month intervals after testing. Data on hospitalizations and deaths are entered, and retrieval programs are available to obtain dates and information regarding the most recent clinical visit and prescription received as well as those regarding hospitalization or death. To avoid bias, the coding of death certificates and other outcome variables was blinded to the predictor (exposure) variables. Although not designed for research purposes, this administrative and clinical database helped us obtain complete follow-up information. Data Analysis All data were entered into R:Base (Microrim, Redmond, Washington) and were analyzed using R:Base, Statgraphics (Statistical Graphics Corporation, Rockville, Maryland), True Epistat (Epistat Services, Richardson, Texas), Confidence Interval Analysis (American College of Physicians, Philadelphia, Pennsylvania), and EGRET (SERC, Seattle, Washington) on a standard 80386-SX-based personal computer (Vectra RS/20C, Hewlett Packard, Palo Alto, California). Survival time in person-days was measured from the time of the exercise test and was censored at the time of noncardiac death, coronary artery bypass surgery, or percutaneous transluminal coronary angioplasty. Survival Analysis Analysis was done to predict cardiovascular deaths and infarct-free survival (that is, cardiovascular death and nonfatal myocardial infarction). Kaplan-Meier survival curves were evaluated stratifying one or more variables to explore the data for interactions. The Cox proportional-hazard model was then applied to clinical and resting electrocardiographic variables, hemodynamic variables from treadmill testing, and electrocardiographic changes and angina during the treadmill test. Each variable grouping was also analyzed independently and by combining the strongest or most logical variables. Analysis was also done on the total group, including those who underwent catheterization (588 patients) because they were seen before the decision to catheterize. Results Follow-up Computed clinical information was available for all 2546 patients, and follow-up was initiated in February 1991. Of these, 85% were confirmed to be alive by a clinic visit or prescription filled at a minimum of 1 year after their treadmill date, and 187 (7.5%) had died after a mean follow-up period of 45 17 months. Contact either by telephone or letter led to follow-up and verification of vital status in 99%. After review of autopsy, death certificate, or hospital charts, 119 of the deaths (63%) were classified as cardiovascular. Forty-four patients had nonfatal myocardial infarctions, 34 developed congestive heart failure, 46 underwent coronary bypass surgery, and 18 received one or more angioplasties. The average annual cardiac mortality rate was 1.5%. Clinical Characteristics Table 1 shows the clinical characteristics of the study cohort grouped by end point. The mean age (SD) was 59 10 years. One fifth of the patients had typical angina pectoris, and one fifth had a history of previous myocardial infarction or electrocardiograms with diagnostic Q waves. Medications were not changed or withheld before exercise testing; 22% were taking -blockers, and 8% were taking digoxin. Statistically significant differences between the no cardiovascular event and cardiovascular death groups were observed for age, congestive heart failure, myocardial infarction, digoxin use, and most resting electrocardiographic abnormalities (P < 0.01). Table 1. Clinical Features of the Total Study Population and Number and Percentage with a Given End Point Hemodynamic and Electrocardiographic Responses Group averages for pre-exercise standing heart rate, systolic blood pressure, and double product were 76 beats per minute, 130 mm Hg, and 9800 (heart rate times systolic blood pressure), respectively. Table 2 shows the hemodynamic and electrocardiographic responses during the exercise test. No significant differences were found among end point groups for perceived exertion and occurrence of premature ventricular contractions. Table 2. Hemodynamic and Exercise Electrocardiographic Features of the Total Study Population* Cox Proportional Hazards Model The univariate scores and P values for the variables are listed in Appendix Table. No significant interactions were discovered, and thus none are included. Similar results were obtained both when infarct-free survival was considered as an end point (variable order, coefficients, and level of significance) and when the entire cohort was analyzed. The score test statistic listed is the relative weight or importance assigned the variables in the Cox model. Using stepwise selection, the Cox model was allowed to build on each variable group (clinical variables alone entered first with subsequent addition of other variables) to arrive at the final model that chose history of congestive heart failure or digoxin use, the change in systolic blood pressure score, exercise capacity (METs), and exercise-induced ST depression. A score was then formed using the coefficients from the Cox model with only these four variables entered as follows: 5 x (congestive heart failure or digoxin use [yes = 1; no = 0]) + exercise-induced ST depression in millimeters + change in systolic blood pressure score METs. Three groups were formed using a scoring system in which 2 indicated low risk, 2 to 2 indicated moderate risk, and greater than 2 indicated high risk. The hazard ratios, confidence intervals (CIs), and P values for these groups are shown in Table 3, and the Kaplan-Meier survival curves are shown in Figure 1. This score enabled identification of a low-risk group (77% of the cohort) with an annual cardiovascular mortality rate of less th

Depression and Coronary Heart Disease

Depression is commonly present in patients with coronary heart disease (CHD) and is independently associated with increased cardiovascular morbidity and mortality. Screening tests for depressive symptoms should be applied to identify patients who may require further assessment and treatment. This multispecialty consensus document reviews the evidence linking depression with CHD and provides recommendations for healthcare providers for the assessment, referral, and treatment of depression.

Effectiveness of Tai Chi exercise in improving aerobic capacity: a meta-analysis.

Purpose:Meta-analysis involves the integration of several studies with small sample sizes, enabling the investigator to summarize research results into useful clinical information. Tai Chi exercise has recently gained the attention of Western researchers as a potential form of aerobic exercise. A goal of this meta-analysis was to estimate the effect of Tai Chi exercise on aerobic capacity. Methods:A computerized search of 7 databases was done using key words and all languages. Sixteen study elements were critically appraised to determine study quality. D-STAT software was used to calculate the standardized mean differences (ESsm) and the 95% confidence intervals (CI), using means and standard deviations (SD) reported on aerobic capacity expressed as peak oxygen uptake (&OV0312;o2peak) (mL · kg−1 · min−1). Results:Of 441 citations obtained, only 7 focused on aerobic capacity in response to Tai Chi exercise (4 experimental and 3 cross-sectional). Older adults including those with heart disease participated (n = 344 subjects); on average men were aged 55.7 years (SD = 12.7) and women 60.7 years (SD = 6.2). Study quality scores ranged from 22 to 28 (mean = 25.1, SD = 2.0). Average effect size for the cross-sectional studies was large and statistically significant (ESsm = 1.01; CI = +0.37, +1.66), while in the experimental studies the average effect size was small and not significant (ESsm = 0.33; CI = -0.41, +1.07). Effect sizes of aerobic capacity in women (ESsm = 0.83; CI = -0.43, +2.09) were greater than those for men (ESsm = 0.65; CI = −0.04, +1.34), though not statistically significant. Aerobic capacity was higher in subjects performing classical Yang style (108 postures) Tai Chi (ESsm = 1.10; CI = +0.82, +1.38), a 52-week Tai Chi exercise intervention (ESsm = 0.94; C = +0.06, +1.81), compared with sedentary subjects (ESsm = 0.80; CI = +0.19, +1.41). Conclusions:This meta-analysis suggests that Tai Chi may be an additional form of aerobic exercise. The greatest benefit was seen from the classical Yang style of Tai Chi exercise when performed for 1-year by sedentary adults with an initial low level of physical activity habits. Recommendations for future research are provided and the effect sizes generated provide information needed for sample size calculations. Randomized clinical trials in diverse populations, including those with chronic diseases, would expand the current knowledge about the effect of Tai Chi on aerobic capacity.

Management of overweight and obesity in adults: behavioral intervention for long-term weight loss and maintenance.

Background: The World Health Organization has identified obesity as a global epidemic. While weight loss is a considerable challenge, long-term maintenance of weight loss is an even greater problem. Aims: This review of the assessment and management of overweight and obesity in adults covers factors contributing to overweight and obesity, components of weight-loss management, and interventions and effects of behavioral treatment for long-term weight loss and maintenance. Methods: A thorough search of the medical and nursing literature recorded in the MEDLINE database from 1995 to 2003 was conducted by using the keywords “overweight”, “obesity”, and “behavioral therapy”. Results: Obesity is a complex, multifaceted condition in which excessive body fat places a person at risk of multiple health problems. Excessive body fat results from energy intake that exceeds energy expenditure. Conclusions: Increasing evidence suggests that obesity is not simply a problem of will power or self-control but a complex disorder involving appetite regulation and energy metabolism that is associated with a variety of comorbid conditions. Effective strategies of weight loss require management strategies in a combined approach of dietary therapy and physical activity by using behavioral interventions.