Erin P. Delaney
University of Delaware
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Featured researches published by Erin P. Delaney.
American Journal of Physiology-heart and Circulatory Physiology | 2010
Erin P. Delaney; Jody L. Greaney; David G. Edwards; William C. Rose; Paul J. Fadel; William B. Farquhar
Recent animal studies have reported that exercise pressor reflex (EPR)-mediated increases in blood pressure are exaggerated in hypertensive (HTN) rodents. Whether these findings can be extended to human hypertension remains unclear. Mean arterial pressure (MAP), muscle sympathetic nerve activity (MSNA), and venous metabolites were measured in normotensive (NTN; n = 23; 60 ± 1 yr) and HTN (n = 15; 63 ± 1 yr) subjects at baseline, and during static handgrip at 30 and 40% maximal voluntary contraction (MVC) followed by a period of postexercise ischemia (PEI) to isolate the metabolic component of the EPR. Changes in MAP from baseline were augmented in HTN subjects during both 30 and 40% MVC handgrip (P < 0.05 for both), and these group differences were maintained during PEI (30% PEI trial: Δ15 ± 2 NTN vs. Δ19 ± 2 HTN mmHg; 40% PEI trial: Δ16 ± 1 NTN vs. Δ23 ± 2 HTN mmHg; P < 0.05 for both). Similarly, in HTN subjects, MSNA burst frequency was greater during 30 and 40% MVC handgrip (P < 0.05 for both), and these differences were maintained during PEI [30% PEI trial: 35 ± 2 (NTN) vs. 44 ± 2 (HTN) bursts/min; 40% PEI trial: 36 ± 2 (NTN) vs. 48 ± 2 (HTN) bursts/min; P < 0.05 for both]. No group differences in metabolites were observed. MAP and MSNA responses to a cold pressor test were not different between groups, suggesting no group differences in generalized sympathetic responsiveness. In summary, compared with NTN subjects, HTN adults exhibit exaggerated sympathetic and pressor responses to handgrip exercise that are maintained during PEI, indicating that activation of the metabolic component of the EPR is augmented in older HTN humans.
Journal of Applied Physiology | 2008
Erin P. Delaney; Colin N. Young; Angela DiSabatino; Michael E. Stillabower; William B. Farquhar
Hypertensive (HTN) animal models demonstrate lower venous compliance as well as increased venous tone and responsiveness compared with normotensive (NTN) controls. However, the extent to which findings in experimental animals can be extended to humans is unknown. Forearm and calf venous compliance were quantified in 9 NTN (23 +/- 1 yr) and 9 HTN (24 +/- 1 yr) men at baseline, after administration of nitroglycerin (NTG), during a cold pressor test (CP), and post-handgrip exercise ischemia (PEI). Individual pressure-volume relationships from a cuff deflation protocol (1 mmHg/s) were modeled with a quadratic regression. Regression parameters beta(1) and beta(2) were used to calculate compliance. A one-way ANOVA was used to compare the beta parameters and a repeated-measures ANOVA was used to compare volumes across all pressures (between groups at baseline and within groups during perturbations). Limb venous compliance was similar between groups (forearm: NTN beta(1) = 0.11 +/- 0.01 and beta(2) = -0.00097 +/- 0.0001, HTN beta(1) = 0.10 +/- 0.01 and beta(2) = -0.00088 +/- 0.0001; calf: NTN beta(1) = 0.12 +/- 0.01 and beta(2) = -0.00102 +/- 0.0001, HTN beta(1) = 0.11 +/- 0.01 and beta(2) = -0.00090 +/- 0.0001). However, at baseline, volume across all pressures (i.e., capacitance) was lower in the forearm (P < or = 0.01) and tended to be lower in the calf (P = 0.08) in HTN subjects. Venous compliance was not altered by any perturbation in either group. Forearm volume was increased during NTG in HTN subjects only. While venous compliance was similar between NTN and HTN adults, HTN adults have lower forearm venous capacitance (volume) which is increased with NTG. These data suggest that young HTN adults may have augmented venous smooth muscle tone compared with NTN controls.
European Journal of Applied Physiology | 2009
M. T. Sausen; Erin P. Delaney; Michael E. Stillabower; William B. Farquhar
American Journal of Physiology-heart and Circulatory Physiology | 2006
William B. Farquhar; Megan M. Wenner; Erin P. Delaney; Allen V. Prettyman; Michael E. Stillabower
American Journal of Physiology-heart and Circulatory Physiology | 2007
Megan M. Wenner; William C. Rose; Erin P. Delaney; Michael E. Stillabower; William B. Farquhar
Archive | 2015
Marcelo R. Risk; Vasilios Lirofonis; Ricardo L. Armentano; Roy Freeman; M. Lindenberger; T. Länne; Erin P. Delaney; Colin N. Young; Angela DiSabatino; Michael E. Stillabower; Ineke Krabbendam; Loes C. A. Jacobs; Fred K. Lotgering; Marc Spaanderman; Nandu Goswami
The FASEB Journal | 2010
Erin P. Delaney; David G. Edwards; William C. Rose; Paul J. Fadel; William B. Farquhar
The FASEB Journal | 2008
Erin P. Delaney; Michael E. Stillabower; William B. Farquhar
The FASEB Journal | 2008
Mark Thomas Sausen; Erin P. Delaney; Michael E. Stillabower; William B. Farquhar
Medicine and Science in Sports and Exercise | 2007
Megan M. Wenner; Erin P. Delaney; Allen V. Prettyman; Michael E. Stillabower; William B. Farquhar