Erizal

SINTESIS DAN KARAKTERISASI BIODEGRADABLE HIDROGEL SUPERABSORBEN POLI(KALIUM AKRILAT)-G-GLUKOMANAN DENGAN TEKNIK IRADIASI GAMMA

Telah dilakukan sintesis satu seri hidrogel superabsorben dari campuran asam akrilat yang dinetralkan sebagian (Dn = 0,5) dengan KOH pada beragam konsentrasi glukomanan (0,25 % hingga 1 %) selanjutnya diiradiasi pada dosis 10 kGy (laju dosis 2,5 kGy/jam) pada suhu kamar. Pengaruh konsentrasi glukomanan terhadap kemampuan menyerap air dan fraksi gel hidrogel dipelajari. Perubahan struktur kimia hidrogel diukur menggunakan Fourier Transform Infra Red (FT-IR) dan morfologi permukaan hidrogel diinvestigasi menggunakan Scanning Electron Microscope (SEM). Hasil evaluasi menunjukkan bahwa pada kondisi optimum (0,5 % glukomanan), rasio swelling hidrogel mencapai nilai 800 g/g dan fraksi gel 94,45 %. Hasil analisis FT-IR mengkonfirmasi terjadinya pergeseran gugus fungsi rangkap dari C=C asam akrilat, pengujian SEM menunjukkan permukaaan hidrogel berpori pori besar yang tidak teratur.

Chitosan-Graft-Poly ( Acrylic Acid ) Superabsorbent Hydrogel with Antimicrobial Activity

Chitosan-graft-poly (acrylic acid) superabsorbent hydrogels by irradiation technique using Υ-rays were carried out in this work. An important application of chitosan-graft-poly (acrylic acid) is the use as water absorbent. For hygiene products application, superabsorbent materials with antimicrobial activities are needed to prevent skin irritation. This research was developed to study the effects of chitosan’s weight in the superabsorbent polymers on the water absorbency, gel content, and Equilibrium Degree of Swelling (EDS). The polymer products were also characterized by FT-IR and SEM. Antimicrobial activity of the hydrogel against Escherichia coli was further investigated. An amount of 0,75 g of chitosan in the reaction mixture resulted in a grafted polymer after Υ-Rays irradiation with the best absorption (420 g g-1 in distilled water, 403,33 g g-1 in 0,009% NaCl solution, and 640 g g-1 in 0,9% urea solution). The gel content as high as 96,85% and EDS as high as 666,67 g g-1 of its dried weight were also obtained by using of 0,75 g of chitosan. The hydrogel was found to be effective against Escherichia coli.

Chitosan Composite of Crab Shell and Hydroxyapatite of Tuna Fish Bone as Biomaterials for Guided Tissue Regeneration

The needs of membrane biomaterials to prevent the migration process of epithelial cells into the bony area after tooth withdrawal process, for filler the holed tooth and to cure gingivitis have increased significantly. In this study, a biomembranes composed of chitosan (CTS) and hydroxyapatite (HA) were prepared. CTS was made of crab shell and HA was made of tuna fish bone. There were 4 groups of treatments, i.e.: K0: only 4 g CTS as a control; K1: combination of 4 g CTS and 2 g HA; K2: combination of 4 g CTS and 4 g HA; and K3: combination of 4 g CTS and 6 g HA. The dried and solid membrane was soaked in 5% Na2SO3 for 1 hour, and then dried in oven at 60 0C for 24 hours. The composite membrane properties, i.e.: water absorption, biodegradation, tensile strength, elongation at break, functional group (by FTIR), and microstructure (by SEM) were evaluated. Result showed that the increasing of HA content in membrane will decreasing the water absorption. The increasing of HA content in membrane and soaking time in Phosphate Buffered Saline (PBS), can increase in biodegradation rate. The biodegradation rate of membrane was about 4.44-6.01% during 27 days of soaking time. The increasing soaking time in PBS can decrease the tensile strength of membrane at about 18.33%-21.17% and decreased the elongation at break at about 26.64%-59.94%. FT-IR analysis indicated that there was a crosslinking between a CTS-HA composite membrane and Na2SO3. Among all the composites studied, CTS-HA (4/2 g/g) composite membrane is the best one for Guided Tissue Regeneration (GTR).