Erkan Alataş

Effect of Hormone Replacement Therapy on Clitoral Artery Blood Flow in Healthy Postmenopausal Women

INTRODUCTION Aging and the decline of ovarian hormonal secretion during menopause may alter libido, and sexual response and functioning. The effects of hormone replacement therapy (HRT) on the genital vascular hemodynamics have been widely studied. However, there is a lack of knowledge about the effect of HRT on basal clitoral blood flow. AIM The aims of this study were to measure clitoral artery blood flow and to determine whether HRT has a significant effect in clitoral artery blood flow in postmenopausal women. METHODS Doppler sonography of clitoral arteries was performed in 25 postmenopausal women aged 51.3 +/- 4.5 years who had been using a continuous combined HRT (0.625 mg of conjugated equine estrogens plus 2.5 mg medroxyprogesterone acetate, in 1 tablet daily) for 2.0 +/- 1.1 years, and the clitoral artery peak systolic velocity, resistance index (RI), and pulsatility index (PI) were measured. Thirty-five postmenopausal women aged 50.0 +/- 4.2 years who had not used HRT served as a control group. MAIN OUTCOME MEASURES Assessment of clitoral blood flow with color Doppler ultrasonography by measuring the peak systolic velocity, RI, and PI. RESULTS Clitoral artery circulation was easily detectable by the color Doppler sonography. The clitoral artery peak systolic velocities were significantly higher in postmenopausal women taking HRT compared with the control group (11.8 +/- 5.2 cm/second vs. 15.0 +/- 5.4 cm/second, P = 0.025). CONCLUSION HRT improves blood flow to the clitoris. A clitoral blood flow evaluation may be proposed as a potential tool to assess the impact of HRT on the genital tissues and to investigate female sexual response disorders in postmenopausal women.

Mature cystic teratoma in round ligament: case report

Our report describes an unusual presentation of mature cystic teratoma. In this case, 3 mature cystic teratomas were encountered during cesarean section, one in each round ligament and the other in the left ovary. According to the literature, round ligament is one of the rarest sites for the presentation of mature cystic teratoma.

Endometriosis in two sisters with Glanzmann's thrombasthenia

OBJECTIVE To present two cases of endometriosis in patients with Glanzmanns thrombasthenia (GT) and discuss the underlying pathophysiology of endometriosis. DESIGN Case report. SETTING Gynecology practice in a university teaching hospital. PATIENT(S) Two sisters, aged 24 and 28 years, previously diagnosed as having GT. INTERVENTION(S) Surgical exploration. MAIN OUTCOME MEASURE(S) Pathologic examination of surgical specimens was performed. RESULT(S) A diagnosis of endometriosis was confirmed pathologically for two sisters previously diagnosed as having GT. CONCLUSION(S) Women with GT seem to represent an important human model of endometriosis from which important data on the pathophysiology of endometriosis can be acquired.

Effects of low-dose 17-β-estradiol plus norethisterone acetate and tibolone on fasting plasma homocysteine levels in postmenopausal women

Background.  Many postmenopausal women currently receive hormone replacement therapy. The use of low‐dose 17β‐estradiol plus norethisterone acetate and tibolone for hormone replacement therapy is not uncommon in postmenopausal women. Homocysteine, which is known to be an independent risk factor for the development of cardiovascular disease, is found in increased levels postmenopause. This study compared the effects of low‐dose 17β‐estradiol plus norethisterone acetate and tibolone on the fasting plasma homocysteine level in healthy postmenopausal women.

Laparoscopic management of a primary ectopic ovarian pregnancy and vaginal douching as a possible cause.

Case reportOvarian pregnancy is a rarely seen form of ectopic pregnancies. We present a 34-year-old women who had a diagnosis of ovarian ectopic pregnancy based on clinical and laboratory findings. Laparoscopic surgery was performed for conservative management of the case. Risk factors are outlined and vaginal douching as a possible cause for ectopic pregnancies have been discussed.ConclusionWe suppose that frequent vaginal douching may be a risk factor for the development of ovarian ectopic pregnancies.

Mutation analysis of HSFY gene by DNA sequencing in Turkish men with idiopathic infertility

Gönderilme tarihi: 21.04.2015 Kabul tarihi: 23.06.2015 Abstract Purpose: In this study we planned to investigate HSFY gene mutations in Turkish infertile men with azoospermia, oligospermia and/or poor motility/morphology. Materials and methods: From three distinct medical centers, 41 Turkish infertile men contributed to this study. The patients included in the study had no endocrine or obstructive causes of spermatogenic failure and no Y microdeletion, and had normal karyotype. Mutation analysis of the HSFY gene was performed by DNA sequencing. Results: No variant could be detected in coding regions and flanking introns of HSFY gene in the study population. Conclusion: This study suggests no relation of HSFY sequence variant with spermatogenic failure and, the clinical molecular approach to diagnosis of individuals with spermatogenic failure is complicated due to extensive genetic heterogeneity and need more study to reveal causative genes and mutations of idiopathic infertility in men.

Validity and reliability of inventory Functional Status Antepartum Period

Purpose:In this study, we planned to measure the validity and reliability of the Inventory of Functional StatusAntepartum Period (IFSAP) for Turkish women. Materials and methods: The study was carried out on women registered at 21 Health Clinics associated with The Denizli Health Department. A total of 184 women from three clinics with different socioeconomic levels were used in the study. The Inventory of Functional Status Antepartum Period and a questionnaire about the sociodemographic characteristics of the women were used to obtain data. Results:Internal construct reliability using average correlations for the subscale item to subscale total scores ranged from 0.50 to 0.64. Subscale to total IFS-AP score correlations ranged from 0.20 to 0.98. Testretest reliability coefficients ranged from 0.73 to 0.98 and the total IFS-F score was 0.99. Construct validity was accomplished by examining the subscale correlations, which ranged from -0.03 to 0.95. Conclusion:The Inventory of Functional Status Antepartum Period is both a valid and a reliable test for the Turkish society. Pam Med J 2014;7(2):125-130