Erkki Mannila

Anti-leukaemic compounds derived from stilbenes in Picea abies bark

Abstract Resveratrol was identified and isolated as a minor stilbene derivative from the bark of Picea abies . Three derivatives of resveratrol and three additional derivatives of the primary stilbenes from P. abies bark were prepared. Improvement over piceatannol in antileukaemic activity was observed in a preliminary test.

Stilbenes from Picea abies bark

Abstract The antileukaemic activity of some stilbenes from the bark of Picea abies was tested. Among them, the main stilbene, isorhapontin, showed antileukaemic activity. The approximate relative percentage of five major stilbenes in the bark was determined by reversed phase HPLC.

Structure analyses of planar polychloroaromatic compounds in environment

Abstract Persistent planar or coplanar aromatic chlorocompounds (PLACs) with structures to fit in the dioxin receptor behave like PCDDs and PCDFs in their analytical clean up with carbon column - reversed elution. Structures of PLACs in emission and environmental samples are screened with GC/MS. IR and NMR spectrometry, GC/GC, model compound mixtures and pure model compounds are also used in structure-specific analysis methods under development. Some alkylated PCDF compounds are indicated in coffee filter paper and in pulp mill effluent. Comparison of levels in salmons and eagles in South-West Finland showed high enrichment rates of some PLACs.

Combustion products of biosludge from pulp mill

Abstract Polychlorinated phenols (PCP), catechols (PCC), guaiacols (PCG), benzenes (PCBz), biphenyls (PCB), dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) were analysed in flue gas, fly ash, grate ash and biosludge samples. Samples were collected from a Finnish pulp mill, where biosludge is used in a power station for energy production.

Synthesis and structure verification of two previously uncharacterized pentachlorobiphenyls: PCB 108 and PCB 127

Abstract The synthesis and structure verification of two previously uncharacterized polychlorinated biphenyl (PCB) congeners mono- ortho -substituted 2,3,3′,4,5′-pentachlorobiphenyl (PCB 108) and non- ortho -substituted 3,3′,4,5,5′-pentachlorobiphenyl (PCB 127) is described. The synthesis was done by the method of aromatic arylation in the presence of isopentyl nitrite. The purification and separation of the compounds was done by flash-chromatography on Al2O3- and charcoal columns. The structures were verified by 1H NMR, 13C NMR, IR and mass spectroscopy.