Esteban Martinez
Autonomous University of Barcelona
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Journal of Molecular Medicine | 1993
Pere Domingo; Esteban Martinez; Cecilia Martinez; J. Barrio; Josep Cadafalch
Neopterin has been proven useful as a screening test for cytomegalovirus infection in blood donors [3]. It is widely accepted as a prognostic marker of human immunodeficiency virus (HIV) infection, and its increase is generally thought to correlate with the degree to which cellular immunity is activated in HIV infection [1, 2]. However, changes in serum concentrations of neopterin may be due not only to progression of HIV infection but also to the development of opportunistic infections, and for this reason its monitoring may provide early evidence of the appearance of acquired immunodeficiency syndrome. We are prospectively following 380 HIV-infected patients who have had serum neopterin, /~2-microglobulin and adenosine deaminase (ADA) concentrations measured at intervals of 3-6 months. The /~2-microglobulin level was measured by radioimmunoassay (/~2-micro RIA, Pharmacia Diagnostics, Uppsala, Sweden), neopterin by radioimmunoassay (Immutest neopterin, Henning Berlin, Berlin, FRG), and ADA by a kinetic ultraviolet method (Boehringer Mannheim, Mannheim, FRG). At baseline, staging of HIV infection in our patients were as follows (Centers for Disease Control): 198 (53.2%) in stage II, 55 (14.8%) in stage III, and 119 (32%) in stage IV. Serum neopterin and ADA levels significantly increased with progression of the disease (Table 1). Furthermore, a high correlation between serum levels of neopterin and those of/~2-microglobulin (r=0.658, P=0.0001) and CD4 cell count (r=0.364, P= 0.0001) was found in our patients. ADA levels showed a lower correlation with ,62-microglobulin (r=0.17, P=0.001) and neopterin (r=0.13, P=0.02) and no correlation with CD4 count (r=0.08, P=0.11). During a mean follow-up time of 8.3-+3.4 months, 20 patients (5.2%) developed opportunistic infections: pulmonary tuberculosis (4), Pneumocystis carinii pneumonia (4), generalized cytomegalovirus infection (3), disse-
Clinical Infectious Diseases | 1992
Esteban Martinez; Pere Domingo
Clinical Infectious Diseases | 1995
Pere Domingo; Rosa Muñoz; Guillem Frontera; Roser Pericas; Esteban Martinez
Clinical Infectious Diseases | 1992
Esteban Martinez; Pere Domingo; Sambeat Ma; Josep Cadafalch
Clinical Infectious Diseases | 1994
Esteban Martinez; Eduard Muniz; Pere Domingo
Clinical Infectious Diseases | 1994
Joaquín López-Contreras; Pere Domingo; Mireia Puig; Esteban Martinez
The Lancet | 1992
Pere Domingo; Esteban Martinez; Cecilia Martinez; Fuster M; Mariano Cortés; Sambeat Ma; Josep Cadafalch
Clinical Infectious Diseases | 1992
Esteban Martinez; Pere Domingo
Clinical Infectious Diseases | 1995
Esteban Martinez; Pere Domingo; Guillem Verger; Guillem Prats
The Lancet | 1992
José Pedreira; Antoni Castro; C Pereiro; C Barbuzano; Alexander Krämer; JamesJ. Goedert; Helmut Wachter; Dietmar Fuchs; Pere Domingo; Esteban Martinez; Cecilia Martinez; Monserrat Fuster; Mariano Cortés; Sambeat Ma; Josep Cadafalch