Esther Aceituno
Autonomous University of Madrid
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Featured researches published by Esther Aceituno.
Allergy | 2004
I. Cortegano; E. Civantos; Esther Aceituno; A. Del Moral; E. López; M. Lombardero; V. del Pozo; Carlos Lahoz
Background: This paper describes the cloning and expression of the Cupressus arizonica pollen protein Cup a 3. In addition, we present its modulation under polluted environmental conditions. Species of the Cupressaceae family are important because of their high sensitization prevalence.
Clinical & Experimental Allergy | 2000
Esther Aceituno; V. del Pozo; Ascensión Minguez; Ignacio Arrieta; I. Cortegano; B. Cárdaba; Soledad Gallardo; Marta Rojo; Pilar Palomino; Carlos Lahoz
The family Cupressaceae is a relevant source of allergens that causes winter respiratory allergies. Cloning and sequencing the major antigen of Cupressus arizonica is important for a better diagnosis and treatment of sensitized patients.
European Journal of Clinical Investigation | 1999
L. Sánchez de Miguel; T. de Frutos; Fernando González-Fernández; V. Del Pozo; Carlos Lahoz; Ana Jiménez; Luis Rico; Rondón García; Esther Aceituno; I. Millás; Juan Gómez; J. Farré; S. Casado; A. López-Farré
Inflammatory related cardiovascular disease, i.e. cardiac allograft rejection, myocarditis, septic shock, are accompanied by cytokine production, which stimulates the expression of inducible nitric oxide (iNOS).
Molecular and Biochemical Parasitology | 2000
Ignacio Arrieta; Manuel del Barrio; Luis Vidarte; Victoria del Pozo; Carlos Pastor; Jesús Gonzalez-Cabrero; Blanca Cárdaba; Marta Rojo; Ascensión Minguez; Isabel Cortegano; Soledad Gallardo; Esther Aceituno; Pilar Palomino; Carlos Lahoz
Ingestion of the parasitic nematode Anisakis simplex in undercooked fish can cause severe allergic reactions in some individuals. Using pooled human sera from sensitized patients we have probed an expression library for A. simplex antigens. One positive clone was found to encode a full length 21 kDa protein with strong homology to nematode troponins. The recombinant protein was expressed as a GST-fusion protein and found by immunoblot analysis to react with sera from 20% of allergic patients. The presence of functional EF-hand Ca(2+) binding motifs was demonstrated by gel-shift analysis.
The Journal of Allergy and Clinical Immunology | 2000
Blanca Cárdaba; Isabel Cortegano; Fernando Florido; Ignacio Arrieta; Esther Aceituno; Victoria del Pozo; Soledad Gallardo; Marta Rojo; Pilar Palomino; Carlos Lahoz
BACKGROUND The major antigen of olive tree pollen, Ole e 1, produces an IgE response restricted by DQ2. OBJECTIVE Our purpose was to further analyze the genetic restrictions associated with IgE and IgG antibodies against Ole e 1 and IgE against the recently described antigen Ole e 3. METHODS Twenty-two nuclear olive pollen-allergic families (n = 88) were selected. DRB1 and DQB1, TCR-Valpha 8.1, the high-affinity receptor of IgE (FcepsilonRI-beta) Rsa I exon 7 and intron 2 and TNF-beta (LTalpha-Nco I) polymorphisms were determined by PCR and analyzed for association with allergic traits by the multiallelic transmission disequilibrium test. RESULTS Significant associations were found among HLA-DQB1*0201 (n = 29) and high levels of IgG (P =.023) and IgE (P =.0136) antibodies to Ole e 1 and with IgE specific to Ole e 3 (P =.0368). DRB1*0701 was associated with high levels of total serum IgE (P =.04) and IgG against Ole e 1 (P =.025). The FcepsilonRI-beta Rsa I exon 7, allele 1 (n = 39), was associated with high levels of total serum IgE (P =. 01), IgE antibodies against Olea europaea extract (P =.004), and specific antibodies to Ole e 1, IgG (P =.04), and IgE (P =.006). The FcepsilonRI-beta Rsa I intron 2, allele 2 (n = 33), was associated with IgE antibodies to O europaea extract (P =.003) and specific antibodies to Ole e 1, IgG (P =.025), and IgE (P =.05). CONCLUSIONS We found a new association between IgE antibody response to Ole e 3 and DQB1*0201 and verified the previously reported association between Ole e 1-specific response and DQB1*0201. Also, the association between FcepsilonRI-beta and IgE antibodies against Ole e 1 was demonstrated.
International Archives of Allergy and Immunology | 2001
Blanca Cárdaba; Miriam F. Moffatt; Eduardo Fernández; Aurora Jurado; Marta Rojo; Milagros García; Ignacio J. Ansotegui; Isabel Cortegano; Ignacio Arrieta; Miguel A. Etxenagusia; Victoria del Pozo; Javier Urraca; Esther Aceituno; Soledad Gallardo; Pilar Palomino; William Cookson; Carlos Lahoz
Background: Spanish gypsies have traditionally lived as nomads, a reason why few epidemiological studies were done in this ethnic group. However, the high prevalence of asthmatic diseases demonstrated in a population residing in the North of Spain induces us to analyse whether it was due to the influence of genetic loci previously implicated in other population studies as causing the disorders. Methods: DRB1* and DQB1* HLA class II, TCR-Vα8.1, FcΕRI-β Rsa I exon 7 and intron 2, TNF-β (LTα-Nco I) and CD14, were tested for association with asthma and atopy by multiple regression analysis, in 5 families comprising 87 individuals. Results: Significant associations were found with DQB1*02 (p = 0.02) and DQB1*0301 (p = 0.008) and elevated levels of total serum IgE. A negative association (p = 0.02) was found between total serum IgE and DRB1*14. FcΕRI-β Rsa I-In2 allele 1 was associated with high levels of total serum IgE (p = 0.04). Levels of Der p 1 IgE antibodies were negatively associated with DRB1*11-DQB1*0301 (p = 0.007), and positively with TCR Vα-8 allele 1 (p = 0.04) and with FcΕRI-β Rsa I-In2 allele 1 (p = 0.009). Conclusions: Our results do not show any association between asthma and the genetic loci studied although they do suggest the existence of multiple genetic influences on the allergic response in these families.
Glycobiology | 2000
Isabel Cortegano; Victoria del Pozo; Blanca Cárdaba; Ignacio Arrieta; Soledad Gallardo; Marta Rojo; Esther Aceituno; Toshiyuki Takai; Sjef Verbeek; Pilar Palomino; Fu Tong Liu; Carlos Lahoz
Tissue Antigens | 2000
B. Cárdaba; J. Ezendam; Soledad Gallardo; V. Del Pozo; M. Izquierdo; C. Martín; I. Cortegano; Esther Aceituno; Marta Rojo; Ignacio Arrieta; Pilar Palomino; Manuel Posada; Carlos Lahoz
/data/revues/00916749/v105i2sP1/S0091674900900794/ | 2011
Blanca Cárdaba; Isabel Cortegano; Fernando Florido; Ignacio Arrieta; Esther Aceituno; Victoria del Pozo; Soledad Gallardo; Marta Rojo; Pilar Palomino; Carlos Lahoz
The Journal of Allergy and Clinical Immunology | 2002
Carlos Lahoz; Isabel Cortegano; Ascensión Minguez; Victoria del Pozo; E. Civantos; Blanca Cárdaba; Esther Aceituno; Marta Rojo; Soledad Gallardo; Pilar Palomino