Esvet Akbas

Studies on Reactions of Pyrimidine Compounds: Synthesis and Reactions of 5-Benzoyl-4,6-Diphenyl-1,2,3,4-Tetrahydro-2-Thioxopyrimidine

The 5-benzoyl-4,6-diphenyl-1,2,3,4-tetrahydro-2-thioxopyrimidin ( 1 ) have been prepared via Biginelli cyclocondensation reaction in acetic acid under reflux condition in good yield (93%). Reactions of 1 and iodomethane to afford thiopyrimidine compounds 3 and 5 . Also, the acetylation of compounds 1 and 3 gave 3-acetyl thioxopyrimidine 2 and methylthiopyrimidine 4 , respectively. Thioxopyrimidine derivative 6 was synthesized from 1 and POCl3/DMF. Furthermore, the starting compound 1 were cyclized with various bromo compounds to the thiazolopyrimidine 7 , 8 , 9 and pyrimido[2,3-b]thiazine 10 derivatives, in approximately 55–78% yields. The purpose of synthesizing the thioxopyrimidine derivatives is because of the high biological activities. All of these derivatives have been characterized by analytical and spectroscopic studies and the reaction mechanism is discussed.

Synthesis and spectral studies of pyranone derivative and its Cu(II), Co(II), Ni(II) and Zn(II) complexes

Under the thermolysis condition, 5-phenyl-2,3-dihydro-2,3-furandione (IV) in inert aprotic solvents as p-xylene at 130–140°C yields 3-benzoyl-4-hydroxy-6-phenyl-2H-pyran-2-one (VI) via phenyl ketene (V). The compound (VI) was converted into the corresponding 3-benzoyl-4-hydroxy-6-phenylpyridin-2(1H)-one (VII), and 3-benzoyl-2-oxo-6-phenyl-2H-pyran-4-yl acetate (VIII), by its reactions with ammonium hydroxyde, and acetic anhydride, respectively. On the other hand, a series of new various metal complexes (IX-XIa, XIb) of VI was synthesized. The results suggest that the compound VI as bidentate ligand indicate a binuclear structure for the Cu(II) complex with square-planar geometry. The Ni(II) and Zn(II) complexes are of tetrahedral and the Co(II) complex is also octahedral geometry with water molecules at the axial positions. The structures of compounds and complexes were characterized on the basis of elemental analysis, Mass, IR, 1H, and 13C NMR spectra.

Synthesis of the 3,5-diphenyl-1H-pyrazole and cytogenetic and oxidative alterations after exposure of cultured human whole blood cells

Abstract The 3,5-diphenyl-1H-pyrazole was obtained by condensation reaction of dibenzoylmethane and thiosemicarbazide in acetic acid under conventional heating and microwave irradiation method. The structure of the 3,5-diphenyl-1H-pyrazole confirmed by IR, 1H, and 13C NMR and X-ray diffraction and the geometry optimization was carried out using density functional theory (DFT) methods at B3LYP/6-31G, 6-31G(d), 6-31G(d, p), 6-311G(d, p), 6-311G(2d, 2p), 6-31+G(d, p), 6-311++G(d, p) levels. In addition, cytotoxic and oxidative effects were investigated in cultured human peripheral blood cells.

Synthesis of some transition metal complexes of ligands derived from 5-phenyl-2,3-dihydro-2,3-furandione

A series of amide ligands was prepared by the reactions of 5-phenyl-2,3-dihydro-2,3-furandione and aromatic amines. The ligands reacted with Cu(II) and Ni(II) ions to yield mononuclear complexes. The ligands and complexes were characterised by elemental analyses, mass, FTIR, UV-vis, 1H NMR and 13C NMR spectral studies, as well as magnetic moment, AAS and conductance measurements as appropriate

Antioxidant properties of Ferulago angulata and its hepatoprotective effect against N-nitrosodimethylamine-induced oxidative stress in rats

Abstract Context: Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds. Objective: This study determines antioxidant properties of FASB flowers, the levels of minerals and vitamins, and also, evaluates the hepatoprotective effect of flowers against N-nitrosodimethylamine (NDMA) induced on liver tissue by assessing antioxidant enzymes and histopathological parameters in Wistar albino rats. Materials and methods: In the study, the rats were divided into six groups of ten. Control, untreated animals were given 0.9% NaCl. Rats were intraperitoneally given NDMA (10 mg/kg) for the first 7 days. FASB methanol extract (150 and 300 mg/kg) was administered orally for 21 days. Results: α-Tocopherol, retinol, ascorbic acid, total antioxidant activity, phenolic and flavonoid contents of FASB were 0.70 ± 0.13, 0.29 ± 0.03 μg/g, 139.32 ± 7.06 μg/100 g, 171.61 ± 6.05 mM ascorbic acid/g, 90.47 ± 4.11 mg GA/g and 37.39 ± 2.85 mg QE/g. DPPH and hydroxyl radical scavenging activity was obtained IC50 67.34 ± 4.14 and 64.87 ± 4.68 μg/mL, respectively. Discussion and conclusion: The results of the study indicated that FASB flowers contain high levels of vitamins, minerals, total antioxidant activity, phenolics and flavonoids. Due to the positive effect on significant changes in antioxidant enzymes of liver tissue and histopathological examination, it is thought that the plant could be used as a hepatoprotective.