Ettayapuram V. Sunderrajan

Leiomyosarcoma in the mediastinum presenting as superior vena cava syndrome.

The authors report a case of leiomyosarcoma in the mediastinum presenting with superior vena cava obstruction, and also demonstrate the aggressive nature of this tumor in spite of radiotherapy. Where technically feasible, surgery appears to be the treatment of choice. The pathologic and electron microscopic features of this tumor are also described.

Malignant fibrous histiocytoma in the lung masquerading as recurrent pulmonary thromboembolism

Primary pulmonary neoplasms seldom present with classical findings of pulmonary thromboembolism. A patient with primary pulmonary fibrous histiocytoma of the lung presenting as recurrent pulmonary embolism is reported.

Pulmonary perivascular and interstitial inflammation in MRLMpJ-lprlpr mice: III. Modulation by cyclophosphamide and sex hormones in 4- and 6- month-old animals☆

Estradiol (E) abolished clearing of pulmonary inflammation in 2-month-old male MRL/MpJ-lpr/lpr (MRL/l) mice treated with cyclophosphamide (CY). To determine if this effect persisted in animals with advanced disease, we studied male and female MRL/l mice, aged 4 and 6 months (4M, 6M, 4F, and 6F, respectively). Mice were treated, beginning at 1 month of age, with saline, CY (12 mg/kg/day), CY + castration, CY + castration + testosterone (T) in females, and CY + castration + E in males. CY had no effect on pulmonary inflammation in 4M, possibly because of the development of relatively mild lesions. However, CY was highly effective in 6M. CY + castration + T significantly reduced overall inflammation in 6F and showed a trend in 4F. CY alone had a variable effect on bronchoalveolar lavage fluid (BALF) cells and BALF IgG in both males and females. However, concurrent treatment with T was required for histologic changes of pulmonary inflammation to fully respond to a high dose of CY in female mice. E-treated males had reduced responsiveness to CY.

Successful tricuspid valvulectomy without replacement for endocarditis during pregnancy

5 t Gordon DG, Ashburn WL, Slutsky RL: Assessment of ventricular function by first-pass radionuclide angiography. In Berman DS, Mason DT, editors: Clinical nuclear cardiology. New York, 1981, Grune & Stratton, Inc, pp 204-223. Parker .J, Treves S: Radionuclide detection, localization and quantitation of intracardiac shunts and shunts between the great arteries. In Holman BL, editor: Principles of cardiovascular nuclear medicine. New York, 1978, Grune & Stratton Inc. pp 189-218. Howman-Giles RB, Gilday DL, Mason DT, Berman DS: Nuclear cardiology in pediatrics: Evaluation of intracardiac shunts and additional congenital diseases. In Berman DS, Mason DT, editors: Clinical nuclear cardiology. New York, 1981, Grune & Stratton, Inc, pp 285-317. Saalouke MG, Shapiro SR, Perry LW, Scott LP III: Incomplete anomalous pulmonary venous drainage associated with pulmonary vascular obstructive disease. Am J Cardiol 1977; 39:439-444. Perloff J: The clinical recognition of congenital heart disease. Philadelphia, 1978, W. B. Saunders Co, pp 281.284.