Eugene Garrow

Complex left fetal ovarian cyst with subsequent autoamputation and migration into the right lower quadrant in a neonate: case report and review of the literature.

We present a case of a neonate who presented with a right lower quadrant cystic mass. This mass represented a hemorrhagic cyst arising from the left ovary, in which the ovary had undergone torsion, autoamputation, and migration prenatally into the right lower quadrant.

Microdeletion of 16p11.2 associated with endocardial fibroelastosis

Microdeletion of 16p11.2 Associated With Endocardial Fibroelastosis Surasak Puvabanditsin,* Michael S. Nagar, Meera Joshi, George Lambert, Eugene Garrow, and Erik Brandsma Department of Pediatrics, UMDNJ-RWJ Medical School, New Brunswick, New Jersey Department of Pathology, Robert Wood Johnson Medical School, New Brunswick, New Jersey Department of Surgery, SUNY Downstate Medical Center, Brooklyn, New York

Neck pain and stiffness in a toddler with history of button battery ingestion.

BACKGROUND Button batteries within the gastrointestinal system are dangerous and must be suspected after any foreign body ingestion. Common complications include esophageal perforation, fistula formation, and esophageal scarring. OBJECTIVES Spondylodiscitis resulting from button battery ingestion is extremely rare and, to our knowledge, has been described in the literature only once to date. CASE REPORT We will describe a case in which a 14-month-old girl developed spondylodiscitis of T1/T2 after an uncomplicated clinical course involving the ingestion and removal of an esophageal button battery. Discussion will include mechanisms in which button batteries cause harm and notable differences between the previously reported case and ours. CONCLUSIONS We present this case to increase awareness of spondylodiscitis in patients with neck pain or stiffness and a history of button battery ingestion.

Hirschsprung disease presenting as sigmoid volvulus: a case report and review of the literature

While sigmoid volvulus is commonly seen in older patients, it is rarely encountered in children and younger adults. Consequently, heightened awareness of this entity is required to avoid a delay in diagnosis. Among the pediatric and adult cases of colonic volvulus previously reported in the English literature, 23 of the affected individuals have also been diagnosed with Hirschsprung disease (HD). This report describes a 12-year-old male with a history of chronic constipation who presented with vomiting and abdominal distension and was found to have sigmoid volvulus with previously unrecognized HD. The case presentation is followed by a review of the literature describing colonic volvulus secondary to HD in children.

Four-Vessel Umbilical Cord Associated with Multiple Congenital Anomalies: A Case Report and Literature Review

A case is described of a neonate with a four-vessel umbilical cord containing two arteries and two veins. This was due to a rare persistence of the caudal portion of the right umbilical vein. The infant had multiple congenital anomalies including a complete atrioventricular canal, an interrupted inferior vena cava, a double superior vena cava, a left ventricular hypoplasia, dextrocardia, situs ambiguous, and malrotation of the small bowel. The birth of an infant with a four-vessel cord mandates comprehensive work-up for associated anomalies. The literature is reviewed.

Choroid Plexus Hyperplasia and Monosomy 1p36: Report of New Findings:

Monosomy 1p36 is a newly delineated multiple congenital anomalies/mental retardation syndrome characterized by mental retardation, growth delay, epilepsy, congenital heart defects, characteristic facial appearance, and precocious puberty. It is now considered to be one of the most common subtelomeric micro-deletion syndromes. This article reports new findings of choroid plexus hyperplasia and dextrocardia with situs solitus in a patient who had deletion of chromosome 1p26.33 with a brief review of the literature.

Partial trisomy 19p13.3 and partial monosomy 1p36.3: Clinical report and a literature review

We report on a 15‐month‐old girl with a deletion of the distal short arm of chromosome 1p36.3, partial trisomy of the short arm of chromosome 19p13.3, growth and developmental delay, and multiple anomalies including microcephaly, bifrontal prominence, obtuse frontonasal angle, short columella, hypertelorism, sacral dimples, and a bicuspid pulmonary valve. Based on our FISH mapping studies, we estimate the size of the trisomic region of 19p.13.3 to be ∼3.17 Mb, and the region of monosomy for 1p36.3 as 1.3 Mb. This is the first report of a patient with partial trisomy 19p13.3 and partial monosomy p36.3.

A Gelatinous Human Tail With Lipomyelocele: Case Report

We report a female infant who presented with a tail appendage bearing a gelatinous tip and an associated lipomyelocele. Magnetic resonance images revealed the presence of spina bifida and a tract in continuity from the tail to the conus medullaris. The tail was surgically removed. A human tail may be associated with underlying spinal dysraphism. Magnetic resonance or computed tomographic imaging is required in such cases for complete evaluation. This is the first case report of gelatinous-tip human tail.

Our experience with a severe case of aplasia cutis congenita with a large skull defect.

Aplasia cutis congenita (ACC) is an uncommon condition characterized by non-inflammatory, well-demarcated defects of all skin layers and subcutaneous tissue that most commonly involve the scalp (80–90%). Sometimes the underlying bone and dura may also be affected. The condition can present alone or with associated malformations. It was first described in the scalp by Campbell in 1826. Billard was the first to report the involvement of bone and dura underlying the skin defect in 1828. With respect to bone involvement, most of the defects are in the vertex region corresponding with the posterior fontanelle. The etiology of ACC is unknown, most likely due to genetic defects, teratogens, tension, or vascular disruption during fetal development. The estimated incidence is 3/10,000 births, with more than 500 cases having been reported. We report a case of a male infant with trisomy 13 born with a large rhomboid scalp and skull defect measuring 4 9 5 cm. Conservative treatment led to the complete epithelialization of the skin defect. We also describe the different stages of the healing process in our infant.

Case report: Nicolau’s syndrome induced by intramuscular vitamin K injection in two extremely low birth weight infants

A 713 g male infant was born by spontaneous vaginal delivery to a 36 year old primigravida at 24 weeks’ gestation because of active preterm labor. Apgar scores were 5 and 7 at 1 and 5 min, respectively. He required immediate intubation, surfactant administration, and positive pressure ventilation. He received prophylaxis against hemorrhagic disease of the newborn with intramuscular (IM) injection of 0.5 mg vitamin K1 on the left thigh 30 min after birth. He developed a localized erythematous skin reaction on his left thigh within few hours after administration of vitamin K1. The affected area evolved into a circumscribed patch of livedo-like erythema. Due to skin necrosis, denuded skin appeared within a few hours (Fig. 1). An ulcer was noted over the lividoid patch which healed within a week with daily application of Bacitracin ointment (Fig. 2). An atrophic scar remained at the injection site at 7 weeks of age (Fig. 3).