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Eugene Powell

Janssen Pharmaceutica

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Publication

Featured researches published by Eugene Powell.

Bioorganic & Medicinal Chemistry Letters | 2013

A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice

M.N. Greco; Margery A. Connelly; G.C. Leo; M.W. Olson; Eugene Powell; Z. Huang; M. Hawkins; C. Smith; Celine Schalk-Hihi; A.L. Darrow; H. Xin; Wensheng Lang; B.P. Damiano; D.J. Hlasta

By screening directed libraries of serine hydrolase inhibitors using the cell surface form of endothelial lipase (EL), we identified a series of carbamate-derived (EL) inhibitors. Compound 3 raised plasma HDL-C levels in the mouse, and a correlation was found between HDL-C and plasma compound levels. Spectroscopic and kinetic studies support a covalent mechanism of inhibition. Our findings represent the first report of EL inhibition as an effective means for increasing HDL-C in an in vivo model.

Journal of the American Chemical Society | 2002

Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design.

Michael N. Greco; Michael J. Hawkins; Eugene Powell; Harold R. Almond; Thomas W. Corcoran; Lawrence de Garavilla; Jack A. Kauffman; Rosario Recacha; Debashish Chattopadhyay; Patricia Andrade-Gordon; Bruce E. Maryanoff

Journal of Medicinal Chemistry | 2007

Discovery of Potent, Selective, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase

Michael N. Greco; Michael J. Hawkins; Eugene Powell; Harold R. Almond; L. de Garavilla; J Hall; Lisa Minor; Yuanping Wang; Thomas W. Corcoran; E. Di Cera; Angelene M. Cantwell; Savvas N. Savvides; Bruce P. Damiano; Bruce E. Maryanoff

Journal of Medicinal Chemistry | 1998

Orally Active Benzamide Antipsychotic Agents with Affinity for Dopamine D2, Serotonin 5-HT1A, and Adrenergic α1 Receptors

Allen B. Reitz; Ellen W. Baxter; Ellen E. Codd; Coralie B. Davis; Alfonzo D. Jordan; Bruce E. Maryanoff; Cynthia A. Maryanoff; Mark E. McDonnell; Eugene Powell; Michael J. Renzi; Mary R. Schott; Malcolm K. Scott; Richard P. Shank; Jeffry L. Vaught

Archive | 2005

Novel inhibitors of chymase

Michael J. Hawkins; Michael N. Greco; Eugene Powell; Lawrence de Garavilla; Bruce E. Maryanoff

Journal of Medicinal Chemistry | 1992

Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase : use of the hydroxyurea moiety as a replacement for hydroxamic acid

Michael N. Greco; William Hageman; Eugene Powell; Joseph J. Tighe; Francis J. Persico

Archive | 2008

Novel phosphonic acid compounds as inhibitors of serine proteases

Michael N. Greco; Harold R. Almond; Michael J. Hawkins; Eugene Powell

Bioorganic & Medicinal Chemistry Letters | 1996

Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif

Michael N. Greco; Eugene Powell; Leonard R. Hecker; Patricia Andrade-Gordon; Jack A. Kauffman; Joan M. Lewis; Venkatapathy Ganesh; A. Tulinsky; Bruce E. Maryanoff

Organic Letters | 2006

Facile Dephosphonylation of β-Ketophosphonic Acids: Mechanistic Studies

Michael J. Hawkins; Eugene Powell; Gregory C. Leo; Diane A. Gauthier; Michael N. Greco; Bruce E. Maryanoff

Archive | 2005

Inhibitors of chymase

Michael J. Hawkins; Michael N. Greco; Eugene Powell; Lawrence de Garavilla; Bruce E. Maryanoff

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Collaboration

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Michael J. Hawkins

Trevena Inc

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Michael N. Greco

University of Pittsburgh

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Bruce E. Maryanoff

Janssen Pharmaceutica

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Angelene M. Cantwell

Washington University in St. Louis

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Bruce P. Damiano

Johnson

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Savvas N. Savvides

Washington University in St. Louis

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A.L. Darrow

Janssen Pharmaceutica

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B.P. Damiano

Janssen Pharmaceutica

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C. Smith

Janssen Pharmaceutica

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Celine Schalk-Hihi

Janssen Pharmaceutica

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