Eunsoo Sohn
Korea Institute of Science and Technology Information
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Featured researches published by Eunsoo Sohn.
International Immunopharmacology | 2014
Hyun Jung Koo; Weon-Jong Yoon; Eun-Hwa Sohn; Young-Min Ham; Seon-A Jang; Jung-Eun Kwon; Yong Joon Jeong; Jong Hwan Kwak; Eunsoo Sohn; Soo-Young Park; Ki-Hyo Jang; Seung Namkoong; Hyo-Sang Han; Yong-Hwan Jung; Se Chan Kang
Fruits of the Litsea family of trees and shrubs contain biologically active compounds, some of which have been used as natural nutrients and flavoring agents in food. In this study, we identified novel anti-nociceptive effects of the 30% ethanol extract, the CH(2)Cl(2) fraction and the associated active components (Hamabiwalactone A and B) from Litsea japonica fruit by using in vivo peripheral and central nervous pain models. In addition, we compared the anti-inflammatory effects of several fractions from L. japonica fruit extracts using lipopolysaccharide (LPS)-stimulated Raw264.7 cells. The CH(2)Cl(2) fraction of L. japonica fruit (LJM) had an optimal combination of anti-inflammatory effects and low cytotoxicity. Dose response studies were performed to determine the inhibitory effects of LJM on the pro-inflammatory enzymes, COX-2/PGE(2) and NO/iNOS, and pro-inflammatory cytokines, IL-1β, IL-6, and TNF-α. Molecular profiling revealed that LJM exerts anti-inflammatory effects through inhibition of NF-κB and JNK/p38 MAPK signaling in LPS-induced macrophages. This study suggests that CH2Cl2 fraction of L. japonica fruit and its bioactive components are potential candidates as anti-inflammatory and analgesic agents (painkillers) for the treatment of inflammatory diseases.
Marine Drugs | 2015
Jung Dae Lim; Sung Ryul Lee; Taeseong Kim; Seon-A Jang; Se Chan Kang; Hyun Jung Koo; Eunsoo Sohn; Jong Phil Bak; Seung Namkoong; Hyoung Kyu Kim; In Sung Song; Nari Kim; Eun-Hwa Sohn; Jin Han
Fucoidan is an l-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan from Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration of 25% alcohol with or without fucoidan (30 mg/kg or 60 mg/kg) for seven days. Alcohol administration increased serum aspartate aminotransferase and alanine aminotransferase levels, but these increases were suppressed by the treatment of fucoidan. Transforming growth factor beta 1 (TGF-β1), a liver fibrosis-inducing factor, was highly expressed in the alcohol-fed group and human hepatoma HepG2 cell; however, the increase in TGF-β1 expression was reduced following fucoidan administration. Treatment with fucoidan was also found to significantly reduce the production of inflammation-promoting cyclooygenase-2 and nitric oxide, while markedly increasing the expression of the hepatoprotective enzyme, hemeoxygenase-1, on murine liver and HepG2 cells. Taken together, the antifibrotic and anti-inflammatory effects of fucoidan on alcohol-induced liver damage may provide valuable insights into developing new therapeutics or interventions.
Biomedicine & Pharmacotherapy | 2017
Hyun Jung Koo; Sung-Ryul Lee; Kwang Jin Chang; Eunsoo Sohn; Eun-Hwa Sohn; Se Chan Kang; Suhkneung Pyo
The hepatic anti-inflammatory potential of hexane extracts of Dioscorea batatas Decne edible part (EDH-1e) and bark (EDH-2b) were investigated in Western-type diet-fed apolipoprotein E null [ApoE (-/-)] mice and HepG2 cells. EDH-1e and EDH-2b suppressed the increased levels of tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, transforming growth factor beta 1 (TGF-β1), vascular cell adhesion protein 1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1), and reduced infiltration of monocytes into liver tissue. The protein levels of Toll-like receptor 4 (TLR4) were also downregulated by EDH-1e and EDH-2b treatment as were the levels of activator protein 1 (AP-1), c-fos, and c-jun in the livers from Western-type diet-fed ApoE (-/-) mice and in lipopolysaccharide-stimulated HepG2 cells. Taken together, EDH-1e and EDH-2b attenuated hepatic inflammation and fibrosis via suppression of the TLR4-AP1-mediated signaling pathway.
Journal of Pharmaceutical Investigation | 2004
Eun-Hwa Son; Eunsoo Sohn; Suhkneung Pyo
The basic concept underlying gene therapy is that human diseases may be treated by the transfer of genetics material into specific cells of a patient in order to correct or supplement defective genes responsible for disease development. There are several systems that can be used to transfer foreign genetic material into the human body. Both viral and non-viral vectors are developed and evaluated for delivering therapeutic genes. Viral vectors are biological systems derived from naturally evolved viruses capable of transferring their genetics materials into host cells. However, the limitations associated with viral vectors, in terms of their safety, particularly immunogenecity, and their limited capacity of transgenic materials, have encouraged researchers to increasingly focus on non-viral vectors as an alternative to viral vectors. Although non-viral vectors are less efficient than viral ones, they have the advantages of safety, simplicity of preparation and high gene encapsulation capability. This article reviews the most recent studies highlighting the advantages and the limitation of gene delivery systems focused on non-viral systems compared to viral systems.
Journal of Food Science and Nutrition | 2007
Hyerim Lee; Hang Do; Sung-Ryul Lee; Eunsoo Sohn; Suhkneung Pyo; Eunwha Son
Journal of Food Science and Nutrition | 2005
Do Hang; Hye-Sook Choi; Se-Chan Kang; Kyung-Ran Kim; Eunsoo Sohn; Suhkneung Pyo; Eunwha Son
Journal of Food Science and Nutrition | 2006
Hye-Sook Choi; Do Hang; Seong-Jun Cho; Se-Chan Kang; Eunsoo Sohn; Sangpil Lee; Suhkneung Pyo; Eunwha Son
Korean Journal of Plant Resources | 2015
Seung Namkoong; Seon-A Jang; Eun-Hwa Sohn; Jong Phil Bak; Eunsoo Sohn; Hyun Jung Koo; Weon-Jong Yoon; Jung-Eun Kwon; Yong Joon Jeong; Xue Meng; Hyo-Sang Han; Se Chan Kang
Korean Journal of Plant Resources | 2014
Hyun Jung Koo; Se Chan Kang; Seon-A Jang; Jung-Eun Kwon; Eunsoo Sohn; Eun-Hwa Sohn
Journal of Open Innovation: Technology, Market, and Complexity | 2018
Bangrae Lee; Eunsoo Sohn; DongKyu Won; Woondong Yeo; KwangHoon Kim; Sanggook Kim