Eva M. Brun
University of Valencia
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Featured researches published by Eva M. Brun.
Tetrahedron Letters | 1998
Eva M. Brun; Isabel Casades; Salvador Gil; Ramon Mestres; Margarita Parra
Abstract Lithium carboxylic acid enediolates are generated efficiently using lithium amides prepared from thienyllithium or butyllithium and either diethylamine, piperazine, N,N′-dibenzylethylenediamine, N-benzylpiperazine or 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane, even in catalytic amounts.
Tetrahedron | 1998
Eva M. Brun; Salvador Gil; Ramon Mestres; Margarita Parra
Abstract High yields in the alkylation of dianions of α,β-unsaturated carboxylic acids with secondary halides can be obtained despite elimination reactions occurring. α-Regioselectivity for the alkylation of but-2-enoic acids ( 1–4 ) is seldom obtained. Although double bond stereoselectivity is higher than 99% for γ-alkylated products, stereoselectivity is rather poor for most of the α-alkylated products.
Tetrahedron-asymmetry | 2001
Eva M. Brun; Salvador Gil; Margarita Parra
Abstract The regio- and stereochemistry of the alkylation of dienediolates from unsaturated carboxylic acids with benzylic halides, which often results in mixtures of isomers, can be controlled by means of changes in the lithium amide, allowing the α-regioisomer to be obtained as the major diastereoisomer. In addition, when chiral amines are used, moderate enantiomeric excesses can be attained.
Tetrahedron Letters | 1998
Eva M. Brun; Salvador Gil; Ramon Mestres; Margarita Parra; Félix Villar
Abstract Lithium dienolates of saturated or α,β-unsaturated acids react with α-chloroketones provide a convenient method for preparation of highly sustituted β,γ-epoxyacids. These highly reactive compounds lead in most cases to variable ammounts of the corresponding β-lactones and allylic alcohols.
Synthesis | 2000
Eva M. Brun; Salvador Gil; Ramon Mestres; Margarita Parra
Synlett | 1999
Eva M. Brun; Salvador Gil; Ramon Mestres; Margarita Parra
Synthesis | 2000
Eva M. Brun; Salvador Gil; Ramon Mestres; Margarita Parra
Synlett | 2001
Eva M. Brun; Salvador Gil; Margarita Parra
Tetrahedron Letters | 1998
Eva M. Brun; Salvador Gil; Ramon Mestres; Margarita Parra; Félix Villar
Arkivoc | 2003
Eva M. Brun; Salvador Gil; Margarita Parra