Eva-Maria Seidel

The impact of facial emotional expressions on behavioral tendencies in women and men.

Emotional faces communicate both the emotional state and behavioral intentions of an individual. They also activate behavioral tendencies in the perceiver, namely approach or avoidance. Here, we compared more automatic motor to more conscious rating responses to happy, sad, angry, and disgusted faces in a healthy student sample. Happiness was associated with approach and anger with avoidance. However, behavioral tendencies in response to sadness and disgust were more complex. Sadness produced automatic approach but conscious withdrawal, probably influenced by interpersonal relations or personality. Disgust elicited withdrawal in the rating task, whereas no significant tendency emerged in the joystick task, probably driven by expression style. Based on our results, it is highly relevant to further explore actual reactions to emotional expressions and to differentiate between automatic and controlled processes because emotional faces are used in various kinds of studies. Moreover, our results highlight the importance of gender of poser effects when applying emotional expressions as stimuli.

Facial emotion recognition in patients with bipolar I and bipolar II disorder.

OBJECTIVES The ability to recognize facial emotional expressions is a fundamental skill that is necessary for successful social interaction. Previous studies examining this competency in patients with bipolar disorder have generated mixed results. Since bipolar patients show multiple psychosocial difficulties even after remission, this study was aimed at further elucidating emotion recognition deficits in bipolar patients. METHODS AND DESIGN Sixty-two stable bipolar out-patients (37 females; 25 males) and 62 matched healthy controls participated in the study. Explicit facial emotion recognition accuracy was measured with a computerized task. RESULTS Analysis of emotion recognition performance revealed no gender effect but a significant group effect, indicating significantly worse accuracy in patients with bipolar I. Patients with bipolar II disorder did not differ significantly from healthy controls. These results were not correlated with either residual symptoms or intellectual impairments. CONCLUSIONS Based on our results, patients with bipolar disorder vary not only in diagnosis, but also in social cognitive functions, all of which should be addressed in clinical treatment. Future studies should clarify whether emotion recognition deficits are involved in the development and maintenance of bipolar disorder.

Placebo analgesia and its opioidergic regulation suggest that empathy for pain is grounded in self pain

Significance Empathy is of major importance for everyday social interaction. Recent neuroscientific models suggest that pain empathy relies on the activation of brain areas that are also engaged during the first-hand experience of pain. These models rely on rather unspecific and correlational evidence. Here, we show that inducing pain analgesia also reduces pain empathy, and that this is associated with decreased activation of empathy-related brain areas. We then document that blocking placebo analgesia via an opioid antagonist also blocks placebo analgesia effects on pain empathy. This finding suggests that pain empathy is grounded in neural responses and neurotransmitter activity related to first-hand pain. Empathy for pain activates brain areas partially overlapping with those underpinning the first-hand experience of pain. It remains unclear, however, whether such shared activations imply that pain empathy engages similar neural functions as first-hand pain experiences. To overcome the limitations of previous neuroimaging research, we pursued a conceptually novel approach: we used the phenomenon of placebo analgesia to experimentally reduce the first-hand experience of pain, and assessed whether this results in a concomitant reduction of empathy for pain. We first carried out a functional MRI experiment (n = 102) that yielded results in the expected direction: participants experiencing placebo analgesia also reported decreased empathy for pain, and this was associated with reduced engagement of anterior insular and midcingulate cortex: that is, areas previously associated with shared activations in pain and empathy for pain. In a second step, we used a psychopharmacological manipulation (n = 50) to determine whether these effects can be blocked via an opioid antagonist. The administration of the opioid antagonist naltrexone blocked placebo analgesia and also resulted in a corresponding “normalization” of empathy for pain. Taken together, these findings suggest that pain empathy may be associated with neural responses and neurotransmitter activity engaged during first-hand pain, and thus might indeed be grounded in our own pain experiences.

How specific are emotional deficits? A comparison of empathic abilities in schizophrenia, bipolar and depressed patients

Empathy is a rather elaborated human ability and several recent studies highlight significant impairments in patients suffering from psychiatric disorders, such as schizophrenia, bipolar disorder or major depression. Therefore, the present study aimed at comparing behavioral empathy performance in schizophrenia, bipolar and depressed patients with healthy controls. All subjects performed three tasks tapping the core components of empathy: emotion recognition, emotional perspective taking and affective responsiveness. Groups were matched for age, gender, and verbal intelligence. Data analysis revealed three main findings: First, schizophrenia patients showed the strongest impairment in empathic performance followed by bipolar patients while depressed patients performed similar to controls in most tasks, except for affective responsiveness. Second, a significant association between clinical characteristics and empathy performance was only apparent in depression, indicating worse affective responsiveness with stronger symptom severity and longer duration of illness. Third, self-report data indicate that particularly bipolar patients describe themselves as less empathic, reporting less empathic concern and less perspective taking. Taken together, this study constitutes the first approach to directly compare specificity of empathic deficits in severe psychiatric disorders. Our results suggest disorder-specific impairments in emotional competencies that enable better characterization of the patient groups investigated and indicate different psychotherapeutic interventions.

Implicit and explicit behavioral tendencies in male and female depression

Emotional facial expressions are the most salient cues in social life. Successful social interaction is based on correct recognition, interpretation and appropriate reaction to these cues. However, social skill deficits are among the most debilitating symptoms of depression, leading to social withdrawal and aggravating the disorder in various domains. We used an implicit joystick task to measure automatic behavioral tendencies in response to evoked facial expressions (anger, fear, sadness, happiness and neutral). Additionally, we implemented a rating procedure to assess explicit approach and avoidance reactions to these social stimuli. Our sample consisted of 24 depressed patients and 24 healthy controls. Data analysis indicated that depressed patients appear to understand the expression depicted on the emotional faces but react differently to these social cues. Female patients displayed stronger avoidance tendencies in the explicit condition whereas social withdrawal was less pronounced in the implicit condition. Our data suggest that a cognitive bias negatively influences the unimpaired automatic reactions to emotional expressions in depressed patients, and this bias may result in the characteristic social withdrawal.

Risk or resilience? Empathic abilities in patients with bipolar disorders and their first-degree relatives

Endophenotypes are intermediate phenotypes which are considered a more promising marker of genetic risk than illness itself. While previous research mostly used cognitive deficits, emotional functions are of greater relevance for bipolar disorder regarding the characteristic emotional hyper-reactability and deficient social-emotional competence. Hence, the aim of the present study was to clarify whether empathic abilities can serve as a possible endophenotype of bipolar disorder by applying a newly developed task in bipolar patients and their first-degree relatives. Three components of empathy (emotion recognition, perspective taking and affective responsiveness) have been assessed in a sample of 21 bipolar patients, 21 first-degree relatives and 21 healthy controls. Data analysis indicated significant differences between controls and patients for emotion recognition and affective responsiveness but not for perspective taking. This shows that in addition to difficulties in recognizing facial emotional expressions, bipolar patients have difficulties in identifying emotions they would experience in a given situation. However, the ability to take the perspective of another person in an emotional situation was intact but decreased with increasing severity of residual hypomanic and depressive symptoms. Relatives performed comparably bad on emotion recognition but did not differ from controls or patients in affective responsiveness. This study is the first to show that deficient emotion recognition is the only component of empathy which forms a possible endophenotype of bipolar disorder. This has important implications for prevention strategies. Furthermore, changes in affective responsiveness in first-degree relatives show a potential resilience marker.

fMRI measurements of amygdala activation are confounded by stimulus correlated signal fluctuation in nearby veins draining distant brain regions

Imaging the amygdala with functional MRI is confounded by multiple averse factors, notably signal dropouts due to magnetic inhomogeneity and low signal-to-noise ratio, making it difficult to obtain consistent activation patterns in this region. However, even when consistent signal changes are identified, they are likely to be due to nearby vessels, most notably the basal vein of rosenthal (BVR). Using an accelerated fMRI sequence with a high temporal resolution (TR = 333 ms) combined with susceptibility-weighted imaging, we show how signal changes in the amygdala region can be related to a venous origin. This finding is confirmed here in both a conventional fMRI dataset (TR = 2000 ms) as well as in information of meta-analyses, implying that “amygdala activations” reported in typical fMRI studies are likely confounded by signals originating in the BVR rather than in the amygdala itself, thus raising concerns about many conclusions on the functioning of the amygdala that rely on fMRI evidence alone.

Who is to blame? Neural correlates of causal attribution in social situations.

In everyday life causal attribution is important in order to structure the complex world, provide explanations for events and to understand why our environment interacts with us in a particular way. This study used functional magnetic resonance imaging (fMRI) in 30 healthy subjects to separate the neural correlates of self vs. external responsibility for social events and explore the neural basis of self-serving attributions (internal attributions of positive events and external attributions of negative events). We presented short sentences describing positive and negative social events and asked participants to imagine the event, to decide the main cause and assign it to one of the categories (internal vs. external). FMRI data were analyzed using a 2 × 2 factorial design with the factors emotional valence and attribution. Internal compared to external attribution revealed activations along the right temporoparietal junction (TPJ). The reverse contrast showed a left lateralized network mainly involving the TPJ, the precuneus and the superior/medial frontal gyrus. These results confirmed the involvement of a fronto-temporoparietal network in differentiating self and external responsibility. Analysis of the self-serving bias yielded activation in the dorsal anterior cingulate and in the dorsal striatum, suggesting a rewarding value of these attributions.

Reduction of empathy for pain by placebo analgesia suggests functional equivalence of empathy and first-hand emotion experience.

Previous research in social neuroscience has consistently shown that empathy for pain recruits brain areas that are also activated during the first-hand experience of pain. This has been interpreted as evidence that empathy relies upon neural processes similar to those underpinning the first-hand experience of emotions. However, whether such overlapping neural activations imply that equivalent neural functions are engaged by empathy and direct emotion experiences remains to be demonstrated. We induced placebo analgesia, a phenomenon specifically modulating the first-hand experience of pain, to test whether this also reduces empathy for pain. Subjective and neural measures of pain and empathy for pain were collected using self-report and event-related potentials (ERPs) while participants underwent painful electrical stimulation or witnessed that another person was undergoing such stimulation. Self-report showed decreased empathy during placebo analgesia, and this was mirrored by reduced amplitudes of the pain-related P2, an ERP component indexing neural computations related to the affective-motivational component of pain. Moreover, these effects were specific for pain, as self-report and ERP measures of control conditions unrelated to pain were not affected by placebo analgesia. Together, the present results suggest that empathy seems to rely on neural processes that are (partially) functionally equivalent to those engaged by first-hand emotion experiences. Moreover, they imply that analgesics may have the unwanted side effect of reducing empathic resonance and concern for others.

Neural correlates of social approach and withdrawal in patients with major depression

Successful human interaction is based on correct recognition, interpretation, and appropriate reaction to facial affect. In depression, social skill deficits are among the most restraining symptoms leading to social withdrawal, thereby aggravating social isolation and depressive affect. Dysfunctional approach and withdrawal tendencies to emotional stimuli have been documented, but the investigation of their neural underpinnings has received limited attention. We performed an fMRI study including 15 depressive patients and 15 matched, healthy controls. All subjects performed two tasks, an implicit joystick task as well as an explicit rating task, both using happy, neutral, and angry facial expressions. Behavioral data analysis indicated a significant group effect, with depressed patients showing more withdrawal than controls. Analysis of the functional data revealed significant group effects for both tasks. Among other regions, we observed significant group differences in amygdala activation, with patients showing less response particularly during approach to happy faces. Additionally, significant correlations of amygdala activation with psychopathology emerged, suggesting that more pronounced symptoms are accompanied by stronger decreases of amygdala activation. Hence, our results demonstrate that depressed patients show dysfunctional social approach and withdrawal behavior, which in turn may aggravate the disorder by negative social interactions contributing to isolation and reinforcing cognitive biases.