Everard W. Thornton

Effects of Lilly 110140, a specific inhibitor of 5‐hydroxytryptamine uptake, on food intake and on 5‐hydroxytryptophan‐induced anorexia. Evidence for serotoninergic inhibition of feeding

nalorphine. The possibility therefore exists that this variable response to LAAM in monkeys could be due to the differential rates of formation of free and conjugated p-hydroxyacetylbisnormethadol or some other metabolite. This work was supported by NIDA grant DA-00061. ( -)-cc-[2-SH]Acetylmethadol and authentic samples of acetylnorrnethadol, acetylbisnormethadol, methadol, normethadol were provided by Research Triangle Institute, Chemistry and Life Sciences Division, Research Triangle Park, North Carolina, through the courtesy of National Institute on Drug Abuse (NIDA), Rockville, Maryland. The sample of bisnormethadol was a gift from Eli Lilly and Co., Indianapolis, Indiana. The authors are indebted to Dr. Catherine E. Costello of Massachusetts Institute of Technology (Chemistry Department) for the mass spectral studies on the LAAM metabolites. October 20, 1975

Cocaine-induced conditioned taste aversions in rats.

In two separate studies cocaine hydrochloride at doses between 10--36 mg/kg was found to induce a dose-related conditioned taste aversion (C.T.A.) to saccharin, and to be an effective conditioning agent even when injections of the drug were delayed 90 min after saccharin intake. These data contrast with conditioning agent when unjectuons of the drug were delayed 90 min after saccharin intake. These data contrast with an earlier report [3] which suggested that cocaine was totally devoid of aversive properties. However, they do indicate that cocaine is only a weak aversion-inducing agent. In contrast to other drugs, the doses of cocaine which are required to induce a C.T.A. are very large relative to those commonly employed in behavioural studies. The weak potency of cocaine in inducing C.T.A. may be related to the drugs marked potency in the self-administration paradigm. Some possible determinants of cocaines weak effects are discussed.

Perceptions of self-efficacy and rehabilitation among neurologically disabled adults

Objective: To explore constructs relevant to self-efficacy in neurological rehabilitation. Design: Qualitative methods using semi-structured interviews. Setting: Specialist neurological rehabilitation unit, Liverpool, UK. Subjects: Twenty-four patients (12 male) with experience of inpatient rehabilitation, aged 17-59 (mean 38.1) years at onset, with diagnoses of stroke (n = 8), traumatic brain injury (n = 6) or other monophasic neurological impairment (n = 10). Results: Eleven themes emerged from the data that reflect self-efficacy beliefs: self-reliance and independence were deemed important and many patients recognized the importance of determination, making time to take an active role and working in partnership with the multidisciplinary team. Patients had complex information needs but were able to use goal setting and the vicarious experiences of other inpatients to map out the stages of their own recovery. It was important for patients to be able to recognize for themselves that they were making progress and they valued external reassurance on this from other patients, staff and visitors. A number of difficulties were identified that interfered with their developing self-efficacy in rehabilitation, such as structuring their time. Two different models for rehabilitation emerged from the data, ‘recovery’ and ‘adaptation’. Conclusions: Patients consistently identified 11 factors falling in the supraordinate themes of self, others and process, and these influenced their self-efficacy to participate in neurological rehabilitation. Patients consider rehabilitation in terms of either an ‘adaptation’ or ‘recovery’ model.

Effort and stress influence the effect of lesion of the habenula complex in one-way active avoidance learning

Previous studies which have examined the effects of lesions of the habenula on active avoidance learning have not provided unambiguous support for response deficits. Moreover, interpretation of early studies is confounded by large lesions which damaged adjacent structures. We report the effects of smaller circumscribed lesions of the habenula complex on a simple one-way active avoidance paradigm in three separate experiments in which the required operant was a step or jump onto an elevated platform. In the first study involving avoidance of shock of low intensity (0.5 mA) with an average long intertrial interval of 8 minutes, lesioned animals were not significantly different from sham operated controls. However, in following experiments in which stress levels were increased by raising the shock intensity and reducing the intertrial-interval, or in which the operant was made considerably more demanding by raising the height the animals had to jump to make an avoidance response, there were large lesion induced deficits in avoidance responding. The absence of significant differences between lesioned and sham operated controls in escape latencies suggested no lesion induced impairment of the response to the shock. It is suggested that the data not only support an effect of habenular lesions on active avoidance learning but also are consistent with a previous suggestion that the functional effects of lesion of the habenula on behaviour are effected through changes in dopaminergic function.

The effects of neonatal 6-hydroxydopamine induced sympathectomy on response inhibition in extinction

Abstract Investigations of the role of the sympathetic nervous system in affective behaviour are extended by determination of the effects of sympathectomy, induced by neonatal treatment with 6-hydroxydopamine (6-OHDA) on frustration, as assessed by response inhibition in extinction following continuous free operant reward training. The results contrast with previous reports of the effects of this treatment in showing a positive effect on behaviour; specifically in terms of enhanced response rate during extinction in treated animals. Analysis of the results does not support a previous hypothesis for a deficit in the ability to inhibit responding. Though the results are consistent with the theory of equivalence of the aversive affective states of frustration and fear, the evidence for a definitive role of the peripheral nervous system in such states is confounded by changes in central catecholamines by neonatal 6-OHDA treatment. Nevertheless, the results provide further evidence for the importance of catecholamines in affective behaviour.

Development and validation of a self-efficacy measure for people with multiple sclerosis: the Multiple Sclerosis Self-efficacy Scale

The aim of this study is to develop and validate a brief measure of self-efficacy specifically for use with people with multiple sclerosis (MS). Self-efficacy is the subjective belief that one can overcome challenges that one is faced with. In order to incorporate the subjective experiences of individuals with MS, a ‘patient-fo cused’ methodology has been adopted. O pen-ended interviews were used to generate potential scale items. Items were piloted on an initial sample of individuals with MS and reduced to 14 items on the basis of their perceived relevance to this patient group. The final 14-item scale was then used with a further 142 individuals in order to assess its psychometric properties. The scale demonstrated high internal consistency (C ronbach’s alpha-0.81) and test-retest reliability (r-0.81, P-0.001) and acceptable validity. Issues concerning the assessment of validity are discussed in terms of the scale’s relevancy to individuals with MS and the theoretical issues around the construct of self-efficacy. The scale has shown sensitivity to detect change following a brief therapeutic intervention, with an effect size of 0.502. This MS Self-efficacy Scale could, therefore, be a useful tool in the assessment of psychological adjustment and quality-of-life of individuals with MS.

Rasch analysis of the hospital anxiety and depression scale (HADS) for use in motor neurone disease.

BackgroundThe Hospital Anxiety and Depression Scale (HADS) is commonly used to assess symptoms of anxiety and depression in motor neurone disease (MND). The measure has never been specifically validated for use within this population, despite questions raised about the scales validity. This study seeks to analyse the construct validity of the HADS in MND by fitting its data to the Rasch model.MethodsThe scale was administered to 298 patients with MND. Scale assessment included model fit, differential item functioning (DIF), unidimensionality, local dependency and category threshold analysis.ResultsRasch analyses were carried out on the HADS total score as well as depression and anxiety subscales (HADS-T, D and A respectively). After removing one item from both of the seven item scales, it was possible to produce modified HADS-A and HADS-D scales which fit the Rasch model. An 11-item higher-order HADS-T total scale was found to fit the Rasch model following the removal of one further item.ConclusionOur results suggest that a modified HADS-A and HADS-D are unidimensional, free of DIF and have good fit to the Rasch model in this population. As such they are suitable for use in MND clinics or research. The use of the modified HADS-T as a higher-order measure of psychological distress was supported by our data. Revised cut-off points are given for the modified HADS-A and HADS-D subscales.

An analysis of the relationship between hostility and training in the martial arts

Contrasting views and data are available on the issue of whether combative sports facilitate or reduce aggression. In the present study levels of hostility were assessed in two groups of martial arts students using the Buss-Durkee Inventory. Levels of hostility on a variety of the sub-scales were compared with scores from similar samples of participants in a body contact, aggressive but non-combative sport (rugby football) and a competitive sport with no body contact or direct aggression (badminton). When the effects of age and length of training were controlled by use of partial correlation there was no evidence to support group differences in either the combined score from the varied sub-scales of the inventory or the more specific assaultive sub-scale. However, there was evidence to suggest a significant effect of length of training on hostility levels in martial artists. Beginners attracted to the martial arts were more hostile but the hostility declined with the duration of training. No difference was apparent in this respect for students participating in either jui jitsu or karate. It is suggested that such differential effects with respect to length of training may lead to the overall absence of the between-sport differences. The results provide tentative support for the notion that the discipline of the martial arts may reduce assaultive hostility rather than serve as a model for such behaviour, yet support the need for prospective longitudinal studies on intra-individual hostility.

Drug pretreatment effects in drug induced taste aversions: Effects of dose and duration of pretreatment

The effectiveness of a dose of 3.0 mg/kg methamphetamine in inducing a conditioned taste aversion to saccharin was found to be reduced by chronic pretreatment with the same dose of the drug. The degree of attenuation of the aversive properties of the drug was found to be directly proportional to the duration of pretreatment, a pretreatment regime of 9 or more daily injections completely abolishing the aversive properties of the drug. However, such a regime was only slightly effective in attenuating the aversive properties of a higher dose of methamphetamine (10 mg/kg) and failed to attenuate the aversive properties of a number of other drugs (p-chloramphetamine at 5.0 mg/kg, fenfluramine at 5.0 mg/kg and morphine at 20 mg/kg). Interpretations of these data are considered and it is suggested that the most parsimonious explanation of the effectiveness of chronic drug pretreatment in attenuating the aversive properties of a drug is that the effect is due to the development of tolerance to the drug administered.

A randomized group intervention trial to enhance mood and self-efficacy in people with multiple sclerosis.

OBJECTIVES To document mood, self-efficacy, and resiliency in people with multiple sclerosis (MS) following a brief group psychological intervention, and to examine whether benefits were greater than those derived from provision of education or group social interaction. DESIGN A randomized controlled intervention trial assessing outcomes at five time points over a 1-year follow-up. METHODS Participants with MS were assigned to one of three groups: one receiving brief group psychological intervention (PG) comprising three 90 minute cognitive behavioural sessions supported by an Information Booklet dealing with mental and emotional issues relating to MS; a group provided only with educational material - the information booklet group (IBG); and a group who not only received the booklet but also participated in non-structured social discussion (SDG) sessions similar in length and number to PG participants. Outcomes were documented using questionnaires. RESULTS Outcomes were assessed using area under the curve (AUC) analysis: a summary measure that considers individual changes serially over time to provide a more meaningful picture than the one based on single time points. Ninety participants were followed up over the 12-month post-intervention, and their data are included in the analysis. Analyses indicated benefits in all outcome dimensions for the psychotherapeutic (PG) and social discussion groups (SDG) relative to the IBG group, but no differences between PG and SDG. CONCLUSION The study indicates benefits from psychosocial intervention compared with bibliotherapy, with some additional benefit from psychological intervention compared with a social discussion group. Results suggest that much of the benefit may derive from non-specific therapeutic components. Without psychosocial intervention, the psychological status of people with MS worsened over time.