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Dive into the research topics where Ewa Koziorowska-Gawron is active.

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Featured researches published by Ewa Koziorowska-Gawron.


Pharmacogenetics and Genomics | 2012

Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.

Monika Białecka; Mateusz Kurzawski; Anna Roszmann; Piotr Robowski; Emilia J. Sitek; Krystyna Honczarenko; Agnieszka Gorzkowska; Sławomir Budrewicz; Monika Mak; Monika Jarosz; Monika Gołąb-Janowska; Ewa Koziorowska-Gawron; Marek Droździk; Jarosław Sławek

Introduction Elevated plasma homocysteine (Hcy) concentration is an independent risk factor for cardiovascular disease, and its involvement in endothelial cell dysfunction is well established. However, the role of Hcy and folate in the pathogenesis of Parkinson’s disease (PD) remains controversial. Objectives The study was aimed at evaluating the relationships between Hcy, vitamin B12, and folic acid levels in the blood and cognitive status in PD patients with the genetic polymorphisms of MTHFR (rs1801133: C>T-677C>T, rs1801131: A>C-1298A>C), COMT (rs4680: A>G-Val158Met, rs6269: A>G, rs4633: C>T, rs4818: C>G), or SLC19A1 (rs1051266: G>A-80G>A). Methods A total of 502 participants (248 with PD and 254 age-matched and sex-matched controls) were included in the study. The Unified Parkinson’s Disease Rating Scale score, Hoehn–Yahr staging, and the Schwab–England scale were used to assess motor abilities and activity during daily life. Complex psychological examination with a battery of tests was used to classify patients into groups with (PDD) and without (nPDD) dementia. Blood samples were examined for Hcy, vitamin B12, and folic acid levels, as well as polymorphisms in genes related to Hcy metabolism, such as COMT, MTHFR, and SLC19A1(RFC-1). Results The frequency of homozygous COMT rs4680G and rs4633C allele carriers was significantly decreased in PD patients in comparison with the controls (P=0.015; odds ratio=0.60; 95% confidence interval 0.41–0.90 and P=0.020; odds ratio=0.619; 95% confidence interval 0.42–0.92, respectively). No significant differences in the distribution of MTHFR 677C>T, 1298A>C, and SLC19A1 80G>A alleles and genotypes between PD patients and the controls were found. Hcy levels were significantly increased in PD patients (18±7.8 &mgr;mol/l) as compared with the controls (14.0±9.6 &mgr;mol/l, P=10–8) and were significantly associated with the MTHFR 677C>T polymorphism both in PD patients and controls, in which T allele carriers were characterized by markedly elevated Hcy plasma concentrations. No association was observed between Hcy plasma level and COMT and SLC19A polymorphisms. The results of multivariate logistic regression analysis revealed age (P=0.0003) and Hcy plasma levels (P=0.07) as independent risk factors predisposing individuals to PD dementia. The studied polymorphisms were not associated with cognitive status in PD patients. Conclusion The genetic factors studied were not associated with cognitive status in PD patients. Only age and Hcy plasma levels were found to be independent risk factors predisposing individuals to PD dementia. However, COMT: rs4680: A>G and rs4633: C>T polymorphisms were found to significantly affect PD risk, and the MTHFR 677C>T polymorphism helped determine plasma Hcy concentrations.


Neurodegenerative Diseases | 2013

The impact of MRI white matter hyperintensities on dementia in Parkinson's disease in relation to the homocysteine level and other vascular risk factors.

Jarosław Sławek; Anna Roszmann; Piotr Robowski; Mirosława Dubaniewicz; Emilia J. Sitek; Krystyna Honczarenko; Agnieszka Gorzkowska; Sławomir Budrewicz; Monika Mak; Monika Gołąb-Janowska; Ewa Koziorowska-Gawron; Marek Droździk; Mateusz Kurzawski; Tomasz Bandurski; Monika Białecka

Background: The role of white matter hyperintensities (WMH) and homocysteine (Hcy) and other vascular risk factors in the pathogenesis of Parkinsons disease (PD) dementia (PDD) remains unclear. Objective: The aim of the study was to assess the impact of WMH, Hcy and other biochemical and vascular risk factors on PDD. Methods: A total of 192 patients with PD and 184 age- and sex-matched healthy controls were included. A semistructured interview was used to assess demographic and clinical variables with respect to vascular risk factors (arterial hypertension, diabetes mellitus, atrial fibrillation, ischemic heart disease, obliterative atherosclerosis, hypercholesterolemia, smoking, alcohol intake). Unified Parkinsons Disease Rating Scale score, Hoehn-Yahr staging and the Schwab-England activities of daily living scale were used to assess motor abilities and activities of daily living. A complex neuropsychological examination with a battery of tests was used to classify patients into a group with dementia (PDD) and a group without dementia (PD). Neuroradiological examination of MRI scans included visual rating scales for WMH (according to the Wahlund and Erkinjunntti rating scales) and the Scheltens scale for hippocampal atrophy. Blood samples for Hcy, folate, vitamin B12, fibrinogen, lipids, glucose, creatinine, transaminases and thyroid stimulating hormone (TSH) were examined. Results: Among all patients, 57 (29.7%) fulfilled the diagnostic criteria for dementia. Significantly higher Hcy plasma levels were noted in PD and PDD groups compared to controls (p < 0.05) and in PDD when compared to PD (p < 0.05). According to multivariate regression analysis, WMH (Erkinjuntti scale), high Hcy, low vitamin B12 and folate plasma levels were independent risk factors for PDD. Vascular risk factors did not play any role in the pathogenesis of PDD and WMH. Conclusions: WMH along with Hcy, folate and vitamin B12 may impact cognition in PD. Therapy with vitamin B12, folate and catechol-O-methyltransferase inhibitors may play a potential protective role against PDD.


Neurological Sciences | 2012

Parry–Romberg syndrome: clinical, electrophysiological and neuroimaging correlations

S. Budrewicz; Magdalena Koszewicz; Ewa Koziorowska-Gawron; Paweł Szewczyk; Ryszard Podemski; Krzysztof Słotwiński

Parry–Romberg syndrome (PRS) is a rare disorder, described in the nineteenth century by Caleb Parry and Moritz Romberg, characterized by acquired and slowly progressive atrophy of one side of the face. The pathogenesis of PRS is still unclear. Immune-mediated processes are thought to be a basic factor in PRS etiology, but autonomic nervous system might also be impaired. A case of PRS in a 26-year-old woman with coexisting disturbances in the lower left limb is presented. The multimodal electrophysiological studies were done, including electroencephalography, visual, brain auditory, somatosensory and trigeminal somatosensory evoked potentials, blink reflex, standard neurographic and electromyographic examinations, quantitative sensory tests and autonomic tests. Neuroimaging studies consisted of brain MR, single voxel proton MR spectroscopy, diffusion tensor imaging with fiber tractography. Based on multimodal electrophysiological and neuroimaging studies, it was concluded that the impairment in PRS is multisystemic, i.e., motor, sensory, and autonomic. A cortical origin of the symptoms is possible.


Neurological Sciences | 2016

The possible meaning of fractional anisotropy measurement of the cervical spinal cord in correct diagnosis of amyotrophic lateral sclerosis

S. Budrewicz; Paweł Szewczyk; Joanna Bladowska; Ryszard Podemski; Ewa Koziorowska-Gawron; Maria Ejma; Krzysztof Słotwiński; Magdalena Koszewicz

Diagnosis of amyotrophic lateral sclerosis (ALS) is based on clinical criteria and electrophysiological tests (electromyography, and transcranial magnetic stimulation). In the search for ALS biomarkers, the role of imaging procedures is currently emphasized, especially modern MR techniques. MR procedures were performed on 15 ALS patients and a sex- and age-matched control group. The MR examinations were performed with a 1.5-T MR unit, and the protocol consisted of sagittal T1-weighed images, sagittal and axial T2-weighed images, and sagittal T2-weighed FAT SAT images followed by an axial diffusion tensor imaging (DTI) sequence of the cervical spinal cord. FA values in individual segments of the cervical spinal cord were decreased in the ALS group in comparison with the control group. After comparing FA values for anterior, posterior, and lateral corticospinal columns, the greatest difference was observed between the C2 and C5 segments. Spinal cord assessment with the use of FA measurements allows for confirmation of the motor pathways lesion in ALS patients. The method, together with clinical criteria, could be helpful in ALS diagnosis, assessment of clinical course, or even the effects of new drugs. The results also confirmed the theory of the generalized character of ALS.


Journal of Addiction Medicine | 2015

Acute hyperkinetic syndrome due to ephedrone abuse.

Anna Dołgan; Sławomir Budrewicz; Magdalena Koszewicz; Joanna Bladowska; Krzysztof Słotwiński; Mieszko Zagrajek; Ewa Koziorowska-Gawron; Ryszard Podemski

Objectives:A new form of manganese poisoning is related to the intravenous use of self-prepared methcathinone hydrochloride (ephedrone). Manganese encephalopathy typically manifests as a levodopa-resistant parkinsonism. Main Points:A 32-year-old drug-addicted man with acute gait disturbances after the ephedrone injections was presented. Choreic movements, severe postural instability, and “cock-walk” gait were observed. Magnetic resonance imaging T1 images showed high signal intensity of white matter in the basal ganglia and pituitary gland, and T2 images showed decreased signal mostly of globus pallidus with decreased N-acetylaspartate and choline levels in MR spectroscopy. Conclusions:The unusual pattern of MR imaging may explain the unusual clinical symptoms with dominant hyperkinetic syndrome.


European Neurology | 2018

Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis

Ewa Koziorowska-Gawron; Maciej Kaczorowski; Joanna Bladowska; Sławomir Budrewicz; Magdalena Koszewicz; Agnieszka Halon

We present a rare case of primary malignant melanoma of the central nervous system. We underline the difficulties we faced during diagnostic procedures. Finally, postmortem examination revealed the diagnosis of primary pauci-melanotic leptomeningeal melanomatosis.


Advances in Clinical and Experimental Medicine | 2018

Clinical and nutritional correlations in Parkinson's disease: Preliminary report.

Sławomir Budrewicz; Anna Zmarzly; Dominik Raczka; Aleksandra Szczepańska; Ewa Koziorowska-Gawron; Krzysztof Słotwiński; Magdalena Koszewicz

BACKGROUND Parkinsons disease (PD) is one of the most common neurodegenerative disorders. Malnutrition is an essential problem in the late stage of PD. Lowering of body mass is seen in 30% of patients, and malnutrition or the risk of malnutrition in 24% and 60%, respectively. OBJECTIVES The aim of the study was an analysis of the relationships between the parameters of the nutritional stage and the advancement of clinical symptoms in PD patients. MATERIAL AND METHODS A total of 40 patients (18 men, 22 women) with PD were analyzed, mean age: 70.7 years. In all patients, structured anamnesis, Nutrition Risk Screening (NRS 2002), body mass index (BMI), morphology, and basic biochemical tests were conducted. Skin fold thickness was also measured. The results were referred to the score of different scales. RESULTS The study showed a lot of correlations between the severity of PD, mostly motor symptoms in the Unified Parkinsons Disease Rating Scale (UPDRS), and parameters characterizing the patients nutritional status. We revealed a correlation between malnutrition and PD duration, and l-DOPA frequency intake. The global score of parts I, II and III of UPDRS were correlated with the nutritional status. The results confirmed the existence of more severe smell change and taste impairment in the late stage of PD, with more pronounced malnutrition. CONCLUSIONS The duration of PD, motor and non-motor PD symptoms, and the frequency of l-DOPA intake closely correlate with the nutritional status. Understanding of the multifactorial interdependence might be useful in the estimation of the algorithm for monitoring the nutritional status of PD patients and taking early nutritional intervention.


Journal of Orofacial Pain | 2012

The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease.

Magdalena Koszewicz; Magdalena Mendak; Tomasz Konopka; Ewa Koziorowska-Gawron; Sławomir Budrewicz


Journal of the Neurological Sciences | 2015

Effect of deep brain stimulation the subthalamic nucleus on the acoustic parameters of speech in Parkinson’s disease

Ryszard Podemski; Krzysztof Słotwiński; Ewa Koziorowska-Gawron; P. Tabakow; S. Budrewicz; Magdalena Koszewicz


Journal of the Neurological Sciences | 2015

Meaning of malnutrition factors in Parkinson’s disease

S. Budrewicz; A. Zmarzły; Magdalena Koszewicz; A. Szczepanska; Ewa Koziorowska-Gawron; Krzysztof Słotwiński; Ryszard Podemski

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Ryszard Podemski

Wrocław Medical University

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S. Budrewicz

Wrocław Medical University

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Maria Ejma

Wrocław Medical University

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Agnieszka Gorzkowska

Medical University of Silesia

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Krystyna Honczarenko

Pomeranian Medical University

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Magdalena Mendak

Wrocław Medical University

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