Eytan Gershonov
Weizmann Institute of Science
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Featured researches published by Eytan Gershonov.
Journal of Inorganic Biochemistry | 2000
Itzhak Goldwaser; Dov Gefel; Eytan Gershonov; Mati Fridkin; Yoram Shechter
Most mammalian cells contain vanadium at a concentration of about 20 nM, the bulk of which is probably in the reduced vanadyl (+4) form. Although this trace element is essential and should be present in the diet in minute quantities, no known physiological role for vanadium has been found thus far. In the late 1970s the vanadate ion was shown to act as an efficient inhibitor of Na+,K+-ATPase as well as of other related phosphohydrolases. In 1980 vanadium was reported to mimic the metabolic effects of insulin in rat adipocytes. During the last decade, vanadium has been found to act in an insulin-like manner in all three main target tissues of the hormone, namely skeletal muscles, adipose, and liver. Subsequent studies revealed that the action of vanadium salts is mediated through insulin-receptor independent alternative pathway(s). The investigation of the antidiabetic potency of vanadium soon ensued. Vanadium therapy was shown to normalize blood glucose levels in STZ-rats and to cure many hyperglycemia-related deficiencies. Therapeutic effects of vanadium were then demonstrated in type II diabetic rodents, which do not respond to exogenously administered insulin. Finally, clinical studies indicated encouraging beneficial effects. A major obstacle, however, is overcoming vanadium toxicity. Recently, several organically chelated vanadium compounds were found more potent and less toxic than vanadium salts in vivo. Such a newly discovered organic chelator of vanadium is described in this review.
Journal of Medicinal Chemistry | 1996
Eytan Gershonov; Ruth Granoth; Esther Tzehoval; Yehiel Gaoni; Mati Fridkin
Journal of Medicinal Chemistry | 2000
Eytan Gershonov; Itzhak Goldwaser; Mati Fridkin; Yoram Shechter
Journal of Medicinal Chemistry | 2017
Yossi Zafrani; Dina Yeffet; Gali Sod-Moriah; Anat Berliner; Dafna Amir; Daniele Marciano; Eytan Gershonov; Sigal Saphier
Archive | 1997
Matityahu Fridkin; Yoram Shechter; Eytan Gershonov
Molecular Pharmacology | 2000
Itzhak Goldwaser; Sun Qian; Eytan Gershonov; Mati Fridkin; Yoram Shechter
American Journal of Physiology-endocrinology and Metabolism | 2000
Qian Sun; Natesampillai Sekar; Itzhak Goldwaser; Eytan Gershonov; Mati Fridkin; Yoram Shechter
Drugs of The Future | 2001
Yoram Shechter; Itzhak Goldwaser; I. Lavon; Eytan Gershonov; B. Mester; Marina Mironchik; L.P. Pratt; Mati Fridkin
Archive | 1998
Yoram Shechter; Matityahu Fridkin; Itzhak Goldwasher; Eytan Gershonov
International Journal of Peptide and Protein Research | 2009
Noam Greenspoon; Rami Hershkoviz; Ronen Alon; Eytan Gershonov; Barak Lavie; Ofer Lider