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Dive into the research topics where Eytan Gershonov is active.

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Featured researches published by Eytan Gershonov.


Journal of Inorganic Biochemistry | 2000

Insulin-like effects of vanadium: basic and clinical implications

Itzhak Goldwaser; Dov Gefel; Eytan Gershonov; Mati Fridkin; Yoram Shechter

Most mammalian cells contain vanadium at a concentration of about 20 nM, the bulk of which is probably in the reduced vanadyl (+4) form. Although this trace element is essential and should be present in the diet in minute quantities, no known physiological role for vanadium has been found thus far. In the late 1970s the vanadate ion was shown to act as an efficient inhibitor of Na+,K+-ATPase as well as of other related phosphohydrolases. In 1980 vanadium was reported to mimic the metabolic effects of insulin in rat adipocytes. During the last decade, vanadium has been found to act in an insulin-like manner in all three main target tissues of the hormone, namely skeletal muscles, adipose, and liver. Subsequent studies revealed that the action of vanadium salts is mediated through insulin-receptor independent alternative pathway(s). The investigation of the antidiabetic potency of vanadium soon ensued. Vanadium therapy was shown to normalize blood glucose levels in STZ-rats and to cure many hyperglycemia-related deficiencies. Therapeutic effects of vanadium were then demonstrated in type II diabetic rodents, which do not respond to exogenously administered insulin. Finally, clinical studies indicated encouraging beneficial effects. A major obstacle, however, is overcoming vanadium toxicity. Recently, several organically chelated vanadium compounds were found more potent and less toxic than vanadium salts in vivo. Such a newly discovered organic chelator of vanadium is described in this review.


Journal of Medicinal Chemistry | 1996

1-Aminocyclobutanecarboxylic Acid Derivatives as Novel Structural Elements in Bioactive Peptides: Application to Tuftsin Analogs

Eytan Gershonov; Ruth Granoth; Esther Tzehoval; Yehiel Gaoni; Mati Fridkin


Journal of Medicinal Chemistry | 2000

A novel approach for a water-soluble long-acting insulin prodrug: design, preparation, and analysis of [(2-sulfo)-9-fluorenylmethoxycarbonyl](3)-insulin.

Eytan Gershonov; Itzhak Goldwaser; Mati Fridkin; Yoram Shechter


Journal of Medicinal Chemistry | 2017

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

Yossi Zafrani; Dina Yeffet; Gali Sod-Moriah; Anat Berliner; Dafna Amir; Daniele Marciano; Eytan Gershonov; Sigal Saphier


Archive | 1997

Long-acting drugs and pharmaceutical compositions comprising them

Matityahu Fridkin; Yoram Shechter; Eytan Gershonov


Molecular Pharmacology | 2000

Organic vanadium chelators potentiate vanadium-evoked glucose metabolism in vitro and in vivo: establishing criteria for optimal chelators.

Itzhak Goldwaser; Sun Qian; Eytan Gershonov; Mati Fridkin; Yoram Shechter


American Journal of Physiology-endocrinology and Metabolism | 2000

Vanadate restores glucose 6-phosphate in diabetic rats: a mechanism to enhance glucose metabolism

Qian Sun; Natesampillai Sekar; Itzhak Goldwaser; Eytan Gershonov; Mati Fridkin; Yoram Shechter


Drugs of The Future | 2001

A new approach for prolonging the half-life of peptides, proteins and low-molecular-weight drugs in vivo

Yoram Shechter; Itzhak Goldwaser; I. Lavon; Eytan Gershonov; B. Mester; Marina Mironchik; L.P. Pratt; Mati Fridkin


Archive | 1998

Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them

Yoram Shechter; Matityahu Fridkin; Itzhak Goldwasher; Eytan Gershonov


International Journal of Peptide and Protein Research | 2009

Novel ψ-S-CH2 peptide-bond replacement and its utilization in the synthesis of nonpeptidic surrogates of the Leu-Asp-Val sequence that exhibit specific inhibitory activities on CD4+ T cell binding to fibronectin

Noam Greenspoon; Rami Hershkoviz; Ronen Alon; Eytan Gershonov; Barak Lavie; Ofer Lider

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Yoram Shechter

Rappaport Faculty of Medicine

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Matityahu Fridkin

Weizmann Institute of Science

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Mati Fridkin

Rappaport Faculty of Medicine

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Itzhak Goldwaser

Weizmann Institute of Science

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Natesampillai Sekar

Weizmann Institute of Science

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Barak Lavie

Weizmann Institute of Science

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Daniele Marciano

Israel Institute for Biological Research

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Dov Gefel

Barzilai Medical Center

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Esther Tzehoval

Weizmann Institute of Science

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Gali Sod-Moriah

Israel Institute for Biological Research

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