Ezzat Chan Abdullah

Enhancement the Dissolution Rate and Solubility of Poorly Soluble Drugs: Review

The use of reduction and nucleation technologies in nanosize active pharmaceutical ingredient (API) is as an enabling to bring improved drug products to the marketplace demand as well as for improved drug delivery. nanoPharmaceutical field represents a hopeful set of pharmaceutical materials offering the prospect of better alternatives to optimize drug physical properties and biopharmaceutical issues such as solubility, stability and bioavailability in pharmaceutical development without changing the chemical composition of the API, thereby, giving new patentable solid forms. With physically improved solid API may impact the the pharmaceutical intellectual property landscape. Nanoparticle formation is achievable in many ways, although primarily through particle reduction or through manipulation of the nucleation mechanism. Keywords: active pharmaceutical ingredient; drug delivery; ultra rapid freezing.

Storage Conditions and Particle Size Effects on Powder Cohesion Index Using Stable Micro System

Flowability indicates the degree of ease of flow. For dynamic (or aerated) flowability, Hausner Ratio (HR) and Angle of Repose (AOR) have been established as a strong indicator for flowability. In this work the influence of particle size and relative humidity (RH) on the flowability of silica gel and ballotini powders were investigated using a non-aerated method. The non-aerated method is a cohesion index (CI) measurement based on a Stable Micro Systems TA.XT PLUS texture analyzer (SMS). The results of the indicator measured confirmed the general expectation that the fine powders are cohesive and the coarse powders are free-flowing at low RH. An interesting trend was observed on the humidity effect study where in low humidity, the powder maintained to be more free-flowing than the powder after the drying process up to a certain limit of RH. However at humidity above this limit, the flowability indicator of the powder is decreasing below than the measureed dry powder flowability. Moreover the apparatus has proven equipment ability to predict even small changes in cohesion value and that using non-aerated methods is greatly important to evaluate the flowability and the powder behavior under different conditions (dynamic and static). It is observed that there are numerous factors related with powder flowability.