F Arfelli

At the frontiers of digital mammography: SYRMEP

Abstract The SYRMEP (SYnchrotron Radiation for MEdical Physics) collaboration is presently taking data at a beamline at the synchrotron ELETTRA in Trieste to study the performances of a digital silicon pixel imaging system for mammography. Images are obtained with a scanning technique in the energy range 15–30xa0keV. The readout electronics operates in a single photon counting mode with a photon rate of about 10 6 /( mm 2 s ) , which is still 4 times lower than the maximum rate reachable with the present beamline configuration. Two different detector layouts have been designed, the first one consisting of a single-layer silicon microstrip detector positioned edge-on with respect to the beam, and the second innovative one represented by a matrix of these detectors stacked to cover the full beam dimension (100×4 mm 2 ) . We present here the results obtained with a single-layer detector and a double-layer detector (both 5xa0cm wide) with mammographic phantoms and human breast tissue.

A linear array silicon pixel detector: images of a mammographic test object and evaluation of delivered doses

We present images of a mammographic test object obtained using a linear array silicon pixel detector capable of single-photon counting. The detector pixel size was 200 x 300 microns2 and images were acquired by scanning the test object between the laminar detector and the x-ray source with a scanning step of 100 microns. A molybdenum anode tube was used with two different filtrations: 2 mm aluminium and 25 microns molybdenum. Conventional film-screen images were also obtained in order to compare spatial and contrast resolution. In our digital images it is possible to recognize low-contrast details having dimensions smaller than or equal to the dimensions of details visible by means of a clinical mammographic unit. The detection of microcalcifications smaller than 150 microns was possible only when using the Mo filtration. However a copper wire of 50 microns diameter was detectable when embedded in a simulated tissue. We discuss in detail the mean glandular doses (MGDs) delivered during the image acquisition. The MGDs necessary to obtain good-quality images are always smaller than at a conventional mammographic unit. Since MGDs depend on the x-ray spectrum, the dose reduction becomes larger when the applied spectrum is harder than in film-screen acquisition (Al filtration and 35 kVp).

Single-cell resolution in high-resolution synchrotron X-ray CT imaging with gold nanoparticles

Gold nanoparticles are excellent intracellular markers in X-ray imaging. Having shown previously the suitability of gold nanoparticles to detect small groups of cells with the synchrotron-based computed tomography (CT) technique both exxa0vivo and in vivo, it is now demonstrated that even single-cell resolution can be obtained in the brain at least ex vivo. Working in a small animal model of malignant brain tumour, the image quality obtained with different imaging modalities was compared. To generate the brain tumour, 1 × 10(5) C6 glioma cells were loaded with gold nanoparticles and implanted in the right cerebral hemisphere of an adult rat. Raw data were acquired with absorption X-ray CT followed by a local tomography technique based on synchrotron X-ray absorption yielding single-cell resolution. The reconstructed synchrotron X-ray images were compared with images obtained by small animal magnetic resonance imaging. The presence of gold nanoparticles in the tumour tissue was verified in histological sections.

Digital mammography at the Trieste synchrotron light source

The SYRMEP collaboration is developing a digital mammography project using a synchrotron radiation monochromatic X-ray beam and a silicon pixel detector. The combination of a monochromatic laminar beam with a high efficiency laminar detector, capable of single-photon counting, allows one to minimize the radiation dose delivered to the sample, while maximizing contrast resolution and dynamic range. The SYRMEP detector is a silicon microstrip device used in an innovative configuration in which radiation impinges on the side rather than on the surface of the chip and is therefore totally absorbed within the detector active volume. The high contrast resolution and spatial resolution (<100 microns) of the system have been demonstrated by producing images of details from an Ackermann Mammographic Phantom RMI 160 illuminated by a conventional X-ray tube.

Silicon detectors for synchrotron radiation digital mammography

Abstract The knowledge of the dose and of the energy spectrum of the X-rays delivered to the patient during a radiological examination allows in principle the computation of the number of photons per unit surface useful for a good mammography. The film-screen assembly detectors used in the present standard practice require a number of photons per unit surface which, from a statistical point of view, would be unnecessarily high if single photon counting detectors with efficiency near to one were available. We discuss a possible solid state detector with these characteristics. Moreover, we propose the use of an X-ray monochromatic beam from a synchrotron radiation source in order to perform the examination at the energy where the signal to noise ratio has a maximum. Using the proposed detector in such a beam a substantial dose reduction can be foreseen.

Phase Contrast Imaging in the Field of Mammography

It is very well known that imaging low contrast details in soft tissues is the main limitation of conventional X-ray radiology. Phase contrast imaging overcomes this limitation. Up to now, however, all the applications of this technique required high radiation doses, raising several questions about its utilisation in medical radiology.

SYRMEP front-end and read-out electronics

Abstract The SYRMEP approach to digital mammography implies the use of a monochromatic X-ray beam from a synchrotron source and a slot of superimposed silicon microstrip detectors as a scanning image receptor. The microstrips are read by 32-channel chips mounted on 7-layer hybrid circuits which receive control signals and operating voltages from a MASTER-SLAVE configuration of cards. The MASTER card is driven by the CIRM, a dedicated CAMAC module whose timing function can be easily excluded to obtain data-storage-only units connected to different MASTERs: this second-level modular expansion capability fully achieves the tasks of an electronics system able to follow the SYRMEP detector growth till the final size of seven thousands of channels.

A digital readout system for the SYRMEP silicon strip detectors

Abstract The SYRMEP project (SYnchrotron Radiation for MEdical Physics) intends to improve mammography performances using two non-traditional means: synchrotron radiation and silicon detectors. A silicon crystal (the monochromator) allows to choose the optimal beam energy that leads to the maximum signal to noise ratio, while the detectors are arranged to form a matrix of pixels and coupled to low noise high-gain VLSI integrated circuits making the single photon counting technique possible. We present the data acquisition system implemented to read out the VLSI circuit with particular emphasis on two dedicated CAMAC modules that generate the control signals and store the chip digital output on memories that can be accessed via the CAMAC bus. It has been useful in testing the chip performances and can be considered a prototype of the final SYRMEP data acquisition system.

Monochromatic breast CT: absorption and phase-retrieved images

A program devoted to perform the first in-vivo monochromatic breast computed tomography (BCT) is ongoing at the Elettra Synchrotron Facility. Since the synchrotron radiation provides high energy resolution and spatial coherence, phase-contrast (PhC) imaging techniques can be used. The latest high resolution BCT acquisitions of breast specimens, obtained with the propagation-based PhC approach, are herein presented as part of a wider framework, devoted to the optimization of acquisition and reconstruction parameters towards the clinical exam. Images are acquired with a state-of-the-art dead-time-free single-photon-counting CdTe detector with a 60 µm pixel size. The samples are imaged at 32 and 38 keV in continuous rotating mode, delivering 5-20 mGy of mean glandular dose (MGD). Contrast-to-noise ratio (CNR) and spatial resolution performances are evaluated for both absorption and phase-retrieved images considering tumor/adipose tissue interfaces. We discuss two different phase-retrieval approaches, showing that a remarkable CNR increase (from 0.5 to 3.6) can be obtained without a significant loss in spatial resolution. It is shown that, even if the non-phase-retrieved image has a poorer CNR, it is useful for evaluating the spiculation of a microcalcification: in this context, absorption and phase-retrieved images have to be regarded as complementary information. Furthermore, the first full volume acquisition of a mastectomy, with a 9 cm diameter and 3 cm height, is reported. This investigation on surgical specimens indicates that monochromatic BCT with synchrotron radiation in terms of CNR, spatial resolution, scan duration and scan volume is feasible.

Data acquisition, processing and control for the SYRMEP/FRONTRAD experiment

The SYRMEP/FRONTRAD experiment is performing a R&D program in order to assess the performances of a scanning X-ray detector operating at the ELETTRA Synchrotron light source, in an energy range optimized for mammographic imaging. The detector itself consists of a stack of silicon detectors positioned edge-on with respect to the X-ray beam direction. The data acquisition system must perform several tasks: from the control of the motors during the scanning procedure, to the collection of the data that are recorded on CAMAC modules and refer to the slots of the image while it is forming. The system has to process the data during the scan and to store them on a local disk. In addition, the environmental conditions (global dose measured by an ionization chamber, temperature, dark current of the detector and status of the electronics power supplies) have to be monitored and the proper action taken. We have implemented a multiprocessing system using TCP/IP and RPC to manage the tasks. The overall control is done by a GUI built using the Tcl/Tk package.