F. Bitter

Equilibrium (Gated) radionuclide ventriculography

Conclusions1.Radionuclide ventriculography after homogenous tracer distribution provides a reliable noninvasive method for the global and regional assessment of left ventricular function.2.The most important global parameter is the left ventricular ejection fraction, which can be measured accurately. Decrease of ejection fraction during exercise is an important feature of coronary artery disease. Maximal relaxation velocity (fast filling phase) measured from the global time-volume curve, seems to be the most sensitive global parameter of left ventricular insufficiency.3.Regional wall motion abnormalities can be assessed qualitatively from the cineventriculogram (“movie mode”) or in a quantitative manner. During stress, hypokinetic, dyskinetic, and akinetic regions are characteristic features of coronary artery disease.4.The most extensive quantitative evaluation of regional wall motion is based on the regional time-activity curve of the representative heart cycle, which can be obtained reliably. Checking the set of regional time-activity curves with respect to one parameter results in a parametric scan, which displays the distribution of the respective parameter in the left ventricular region.5.In our department, six parametric scans including distribution of amplitude and phase of the first Fourier element are obtained. These six scans describe the regional wall motion reliably and in detail. While determination of ejection fraction and qualitative assessment of regional wall motion has been widely applied, the clinical value of the parametric scans cannot be finally assessed at this time.

Upward creep of the heart in exercise thallium 201 single photon emission tomography : clinical relevance and a simple correction method

The upward creep of the heart during myocardial single photon emission tomography (SPET) acquisition has been reported as a frequent source of false-positive results. The aim of this study was to simplify the detection and correction of this upward creep and to estimate its clinical relevance during routine patient care. To recognize the upward heart motion a straight line was fitted to the upper and lower border of consecutively displayed tomographic projection images. In this way, vertical translation of at least 1 pixel in size could be detected easily. On the assumption of a slow but continuous upward motion a fast interpolation correction method was developed. From 100 consecutive, supine, ergometric exercise studies, 1, 2 or 3 pixels of upward creep were found in 16, 4 or 3 patients, respectively. It was found that an upward creep of at least 2 pixels (7/100 cases) led to evident, mostly antero-septal defects on quantitative bulls-eyes, whereas only upward creeps of 3 pixels or more (3/100 cases) produced false-positive diagnostic results. The simple correction method offered a sufficient compensation of image and/or bulls-eye artefacts. These clinical findings could be reproduced in a computer model. Thus, it can be stated that clinically significant upward creep of the heart during stress SPET acquisition is relatively rare; it may have been overestimated in the past, and its artificial effects can be corrected by a quick and simple algorithm.

The contraction fraction (CF) in myocardial studies with technetium-99m-isonitril (MIBI) ― correlations with radionuclide ventriculography and infarct size measured by SPECT

Criteria for the detection of coronary artery disease in nuclear cardiology include visualization of perfusion defects and functional impairment of contraction. The purpose of this study is to combine both methods in one procedure with the new myocardial perfusion tracer, 99mTc-methoxy-isobutyl-isonitril (MIBI), reducing time and radiation burden to the patient. Following an uncomplicated recovery, ten patients with first myocardial infarction participated in this study. Radionuclide ventriculography (RNV) was performed at rest and during exercise. Within 2–3 days, 370 MBq 99mTc-MIBI were injected and SPECT acquisition commenced 1 h later. Data processing included a scar image in polar coordinates. Areas of significantly reduced tracer uptake were expressed as a percentage of the total myocardial area. Directly following SPECT, resting and maximum exercise gated planar LAO images were recorded and the contraction was quantified. The concept of the contraction fraction (CF) rested on the end systolic change in count distribution: their increase in density and their centripetal concentration. For comparison, geometrical inner edge detection techniques were also applied. All algorithms for describing an EF equivalent were verified by computer simulations, showing a perfect correlation over a wide range of preset EFs. When applied to the patient studies only the non geometric methods revealed a good correlation with the ejection fraction (EF) obtained by RNV, and with the infarct size measured by SPECT. The corresponding correlation coefficients (r), standard errors (SEE) and the regression lines read as follows (in %): CF=0.56×EF+24.8; r=0.87; SEE=4.98; CF=-0.53×SPECT+71.5; r=0.93; SEE=4.19. Thus, estimation of the left ventricular function by the above defined CF is feasible, easy to perform and clinically meaningful. In one procedure with 99mTc-labelled MIBI not only the perfusion abnormalities were detectable, but also any reduction in function by a valied EF equivalent. Although the monochromatic gamma spectrum of the radionuclide provided better tissue penetrating power, the inner edge of the left ventricle was poorly outlined (especially in the stress studies) and does not lend itself to clinical routine practice.

Radionuclide ventriculography (equilibrium gated blood pool scanning) —its present clinical position and recent development

Myocardial scanning (MS) and radionuclide ventriculography (RNV) are the foundation of nuclear cardiology. These procedures aim in two completely different directions: RNV tries to image heart motion, that is, mechanical (pump) function, and therefore belongs to the group of first-order functional imaging (FI, imaging mechanical function), whereas MS is based on myocardial metabolism, and therefore can be attributed to third-order functional imaging (metabolism). This statement is relevant for the assessment of the clinical position of RNV: Third-order (metabolism) functional imaging is the domain of nuclear medicine (NM), whereas first-order FI has to face the competition of alternative noninvasive procedures such as ultrasound (US), digital subtraction angiography (DSA), computer tomography (CT), and nuclear magnetic resonance (NMR). The domain of RNV includes stages two (acute infarction) and three (postinfarction period) of coronary arterial disease (CAD). The advantageous combination of quantitative data on global, left ventricular (LV) function and imaging of regional motion ensures the superiority of RNV over US. However, RNV is inferior to MS in physical examinations in the preinfarction stage of CAD, whereas US is clearly inferior to both NM procedures. Recent progress could be attained by gated SPECT (GASPECT). A proposal is presented for simplification of this time-consuming procedure. Technetium-labeled isonitriles offer the chance for the combination of “perfusion-motion” imaging of the myocardium. However, even standard RNV offers new possibilities. The multitude of parameters produced by quantitation has not yet been exploited completely. This can be done by discriminant analysis. The computer finds out an optimal subset from the whole set of parameters for the solution of a significant clinical problem. The software “learns” to find the “label” of a special pathognomonic entity. This computer work is supported by a relational data bank (Oracle) and an optical disk. Two examples for the effectiveness of the computer in problem solving are presented. It is concluded that RNV, even in the very competitive class of first-order functional imaging, enjoys a preferred position. The future indeed seems brighter because labeled isonitriles offer the chance for the combination of perfusion-motion imaging of the myocardium.

An evaluation of the diagnostic efficacy of phase analysis of data from radionuclide ventriculograms in patients with Wolff-Parkinson-White syndrome

It has been suggested that phase analysis of radionuclide ventriculograms may be of value for detecting and localising the abnormal sequence of ventricular contraction secondary to Wolff-Parkinson-White (WPW) syndrome. The present study was undertaken to test this hypothesis. The space-time sequences of right- and left-ventricular action obtained from radionuclide ventriculograms obtained during rest studies were evaluated in 8 patients with WPW syndrome (confirmed by 12-lead surface electrocardiography) and compared to those of 14 normal subjects. All of the latter showed a consistent ventricular activation pattern, i.e. the first site of ventricular activity in the upper septal region followed by a second site either at the base of the left ventricle or located apically. It was possible to diagnose 11 of the 14 normal subjects (specificity, 79%) and 7 of the 8 patients (sensitivity, 88%). The 4 patients who had been classified as having a left-sided accessory bundle by surface electrocardiography were likewise diagnosed by phase analysis, as were the 2 patients with a confirmed right-sided bypass tract. Two patients with septal posterior accessory pathways could not be identified by phase analysis. Furthermore, cases with an activation pattern which closely resembled that of the 2 patients with right-sided accessory bundles were found to be normal from their ECGs. It is now necessary to evaluate phase analysis against invasive electrophysiological methods in such patients.

Assessment of the left ventricular function with the nuclear stethoscope.

The evaluation of the left ventricular function with the “Nuclear Stethoscope’ was performed on 27 patients with heart diseases. The reproducibility of the measurements was good. Repetitions of EF, ER and EDV estimations yielded errors of 2.63%, 1.45% and 0.31%, respectively. The comparison with the results of camera ventriculography showed a good agreement of EF, contraction velocity parameters and relaxation velocity parameters, with a cor. coeff. of greater or equal to 0.750. An especially high correlation was found between the NS EF and NS ER (r=0.968). It was concluded that the “Nuclear Stethoscope” provides a reliable evaluation of left ventricular function.

Utility of Imaging Techniques to Predict and Manage Patients with Cardiovascular Abnormalities

Newly developed technologies are going to revolutionize the diagnostic procedure in cardiology. Recent progress has been made in nuclear cardiology, sonography, transmission computer tomography and digital video-techniques. Nuclear magnetic resonance seems to offer another possibility for imaging of the heart. Besides the fact, that these procedures are non-invasive and thus avoid the risks of catheter techniques, special advantages of the various techniques are obviously dependant on the cardiac abnormalities under investigation. The information revealed by these various techniques may in some ways even surpass the results obtained by catheter techniques, whereas on some occasions the catheter is obligatory. The history up to the present state of the art of the various techniques has some highlights: Nuclear cardiology started even before artificial radioisotopes were available: In 1927 BLUMGART and WEISS (1) investigated the pulmonary circulation time with the help of radon. In 1948 PRINZMETAL et al.