F. Le Jeune
University of Rennes
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Featured researches published by F. Le Jeune.
Neurology | 2009
F. Le Jeune; Dominique Drapier; Aurélie Bourguignon; Julie Anne Peron; H. Mesbah; Sophie Drapier; Paul Sauleau; Claire Haegelen; David Travers; E. Garin; C.-H. Malbert; Bruno Millet; Marc Vérin
Objective: Apathy may be induced by subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease (PD). We therefore wished to test the hypothesis that apathy induced by STN-DBS correlates with changes in glucose metabolism, using 18FDG-PET. Methods: Twelve patients with PD were assessed 3 months before (M−3) and 3 months after (M+3) STN-DBS with 18FDG-PET and the Apathy Evaluation Scale. Results: Apathy had significantly worsened at M+3 after STN-DBS. Positive correlations were observed between this variation in apathy scores and changes in glucose metabolism, especially in the right frontal middle gyrus (Brodmann area [BA] 10) and right inferior frontal gyrus (BA 46 and BA 47). Negative correlations between the two were observed in the right posterior cingulate gyrus (BA 31) and left medial frontal lobe (BA 9). Conclusion: These preliminary results confirm the role of the subthalamic nucleus in associative and limbic circuitry in humans and suggest that it is a key basal ganglia structure in motivation circuitry.
Brain | 2008
F. Le Jeune; Julie Anne Peron; Isabelle Biseul; S. Fournier; Paul Sauleau; Sophie Drapier; Claire Haegelen; Dominique Drapier; Bruno Millet; E. Garin; J.-Y. Herry; C.-H. Malbert; Marc Vérin
Deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) in Parkinsons disease is thought to produce adverse events such as emotional disorders, and in a recent study, we found fear recognition to be impaired as a result. These changes have been attributed to disturbance of the STNs limbic territory and would appear to confirm that the negative emotion recognition network passes through the STN. In addition, it is now widely acknowledged that damage to the orbitofrontal cortex (OFC), especially the right side, can result in impaired recognition of facial emotions (RFE). In this context, we hypothesized that this reduced recognition of fear is correlated with modifications in the cerebral glucose metabolism of the right OFC. The objective of the present study was first, to reinforce our previous results by demonstrating reduced fear recognition in our Parkinsons disease patient group following STN DBS and, second, to correlate these emotional performances with glucose metabolism using 18FDG-PET. The 18FDG-PET and RFE tasks were both performed by a cohort of 13 Parkinsons disease patients 3 months before and 3 months after surgery for STN DBS. As predicted, we observed a significant reduction in fear recognition following surgery and obtained a positive correlation between these neuropsychological results and changes in glucose metabolism, especially in the right OFC. These results confirm the role of the STN as a key basal ganglia structure in limbic circuits.
Neuropsychologia | 2008
Dominique Drapier; Julie Anne Peron; Emmanuelle Leray; Paul Sauleau; Isabelle Biseul; Sophie Drapier; F. Le Jeune; David Travers; Aurélie Bourguignon; Claire Haegelen; Bruno Millet; Marc Vérin
OBJECTIVE To test the hypothesis that emotion recognition and apathy share the same functional circuit involving the subthalamic nucleus (STN). METHODS A consecutive series of 17 patients with advanced Parkinsons disease (PD) was assessed 3 months before (M-3) and 3 months (M+3) after STN deep brain stimulation (DBS). Mean (+/-S.D.) age at surgery was 56.9 (8.7) years. Mean disease duration at surgery was 11.8 (2.6) years. Apathy was measured using the Apathy Evaluation Scale (AES) at both M-3 and M3. Patients were also assessed using a computerised paradigm of facial emotion recognition [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto: Consulting Psychologist Press] before and after STN DBS. Prior to this, the Benton Facial Recognition Test was used to check that the ability to perceive faces was intact. RESULTS Apathy had significantly worsened at M3 (42.5+/-8.9, p=0.006) after STN-DBS, in relation to the preoperative assessment (37.2+/-5.5). There was also a significant reduction in recognition percentages for facial expressions of fear (43.1%+/-22.9 vs. 61.6%+/-21.4, p=0.022) and sadness (52.7%+/-19.1 vs. 67.6%+/-22.8, p=0.031) after STN DBS. However, the postoperative worsening of apathy and emotion recognition impairment were not correlated. CONCLUSIONS Our results confirm that the STN is involved in both the apathy and emotion recognition networks. However, the absence of any correlation between apathy and emotion recognition impairment suggests that the worsening of apathy following surgery could not be explained by a lack of facial emotion recognition and that its behavioural and cognitive components should therefore also be taken into consideration.
Contrast Media & Molecular Imaging | 2016
A. Kiani; Aurore Esquevin; N. Lepareur; Patrick Bourguet; F. Le Jeune; Jy. Gauvrit
In medical imaging, the continuous quest to improve diagnostic performance and optimize treatment strategies has led to the use of combined imaging modalities. Positron emission tomography (PET) and computed tomography (CT) is a hybrid imaging existing already for many years. The high spatial and contrast resolution of magnetic resonance imaging (MRI) and the high sensitivity and molecular information from PET imaging are leading to the development of this new hybrid imaging along with hybrid contrast agents. To create a hybrid contrast agent for PET-MRI device, a PET radiotracer needs to be combined with an MRI contrast agent. The most common approach is to add a radioactive isotope to the surface of a small superparamagnetic iron oxide (SPIO) particle. The resulting agents offer a wide range of applications, such as pH variation monitoring, non-invasive angiography and early imaging diagnosis of atherosclerosis. Oncology is the most promising field with the detection of sentinel lymph nodes and the targeting of tumor neoangiogenesis. Oncology and cardiovascular imaging are thus major areas of development for hybrid PET-MRI imaging systems and hybrid contrast agents. The aim is to combine high spatial resolution, high sensitivity, morphological and functional information. Future prospects include the use of specific antibodies and hybrid multimodal PET-MRI-ultrasound-fluorescence imaging with the potential to provide overall pre-, intra- and postoperative patient care.
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique | 2018
X. Palard; Anne-Lise Blin; Luc Beuzit; Pierre-Yves Salaun; Anne Devillers; E. Garin; S. Querellou; Patrick Bourguet; F. Le Jeune; H. Saint Jalmes
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique | 2018
X. Palard; Anne-Lise Blin; David Bourhis; E. Garin; Pierre-Yves Salaun; Anne Devillers; S. Querellou; Patrick Bourguet; F. Le Jeune; H. Saint Jalmes
Personalized Medicine in Psychiatry | 2017
J.M. Batail; J. Palaric; M. Guillery; J. Gadoullet; Paul Sauleau; F. Le Jeune; Marc Vérin; Gabriel Robert; Dominique Drapier
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique | 2017
Audrey Riou; Gabriel Robert; Jean-François Houvenaghel; Sophie Drapier; Marc Vérin; F. Le Jeune
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique | 2017
Xavier Palard-Novello; Patrick Bourguet; David Bourhis; F. Le Jeune; E. Garin; Pierre-Yves Salaun; Anne Devillers; Giulio Gambarota; S. Querellou; Hervé Saint-Jalmes
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique | 2017
P.M. David; F. Hives; Xavier Palard-Novello; S. Laffont; Sophie Drapier; H. Mesbah; Anne Devillers; P. Payoux; F. Le Jeune