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Dive into the research topics where F. Shaikh is active.

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Featured researches published by F. Shaikh.


International Journal of Radiation Oncology Biology Physics | 2016

High-Dose, Single-Fraction Irradiation Rapidly Reduces Tumor Vasculature and Perfusion in a Xenograft Model of Neuroblastoma

Ashish Jani; F. Shaikh; Sunjay M. Barton; Callen Willis; Debarshi Banerjee; Jason Mitchell; Sonia L. Hernandez; Tom K. Hei; Angela Kadenhe-Chiweshe; Darrell J. Yamashiro; E.P. Connolly

PURPOSE To characterize the effects of high-dose radiation therapy (HDRT) on neuroblastoma tumor vasculature, including the endothelial cell (EC)-pericyte interaction as a potential target for combined treatment with antiangiogenic agents. METHODS AND MATERIALS The vascular effects of radiation therapy were examined in a xenograft model of high-risk neuroblastoma. In vivo 3-dimensional contrast-enhanced ultrasonography (3D-CEUS) imaging and immunohistochemistry (IHC) were performed. RESULTS HDRT significantly reduced tumor blood volume 6 hours after irradiation compared with the lower doses used in conventionally fractionated radiation. There was a 63% decrease in tumor blood volume after 12-Gy radiation compared with a 24% decrease after 2 Gy. Analysis of tumor vasculature by lectin angiography showed a significant loss of small vessel ends at 6 hours. IHC revealed a significant loss of ECs at 6 and 72 hours after HDRT, with an accompanying loss of immature and mature pericytes at 72 hours. CONCLUSIONS HDRT affects tumor vasculature in a manner not observed at lower doses. The main observation was an early reduction in tumor perfusion resulting from a reduction of small vessel ends with a corresponding loss of endothelial cells and pericytes.


Annals of Vascular Surgery | 2013

Two-Stage Hybrid Repair of a Complex Symptomatic Celiac Aneurysm

Reid A. Ravin; Andrew J. Meltzer; In-Kyong Kim; F. Shaikh; Rajeev Dayal; Roman Nowygrod

We report the case of a novel 2-stage hybrid repair of a complex celiac artery aneurysm. The patient was a 42-year-old man with a proximal celiac artery aneurysm giving rise to distinct right and left hepatic arterial branches. Repair was performed using a staged approach. First, a bifurcated aortohepatic bypass was constructed to the common and left hepatic arteries. After recovering from surgery, he underwent percutaneous embolization of the aneurysm. Completion angiograms demonstrated flow into all celiac branches with successful thrombosis of the aneurysm. At 12-month follow-up, the patient had remained symptom-free with patent bypass grafts and complete aneurysm exclusion. We describe the treatment option we used, which involves repair of a complex celiac aneurysm using a 2-stage, open, endovascular approach.


International Journal of Radiation Oncology Biology Physics | 2014

Comparing Patterns of Recurrence and Survival in Conventionally Fractionated Radiation with Stereotactic Body Radiation Therapy for Early-Stage NSCLC

F. Shaikh; A. Foster; Z. Zhang; Kaitlin M. Woo; S.U. Din; D. Gelblum; Ellen Yorke; Kenneth E. Rosenzweig; Abraham J. Wu; Andreas Rimner


International Journal of Radiation Oncology Biology Physics | 2017

Hypofractionated Whole Breast Irradiation in Women Less Than 50 Years Old Treated on Prospective Protocols: A Report on Long-Term Cosmesis

F. Shaikh; J. Chew; C.A. Perez; M. Tam; Benjamin T. Cooper; O.G. Maisonet; E. Peat; N.E. Huppert; S.C. Formenti; Naamit K. Gerber


International Journal of Radiation Oncology Biology Physics | 2018

Consolidation Radiation Therapy for Extensive Stage Small Cell Lung Cancer: Determining the Optimal Dose Using the National Cancer Data Base

F. Shaikh; P. Wu; M. Tam; N.K. Gerber; Peter B. Schiff; Benjamin T. Cooper


International Journal of Radiation Oncology Biology Physics | 2018

Concordance of Biomarkers and Tumor Location for in-Breast Tumor Recurrences in Early Stage Breast Cancer Patients Treated with Breast Conserving Surgery and Adjuvant RT

Juhi Purswani; F. Shaikh; P. Wu; J. Chun; F.R. Schnabel; N.E. Huppert; C.A. Perez; N.K. Gerber


International Journal of Radiation Oncology Biology Physics | 2018

Hypofractionated whole breast irradiation in women less than 50 years old treated on four prospective protocols

F. Shaikh; Jessica Chew; Tsivia Hochman; Juhi Purswani; O.G. Maisonet; Elecia Peat; N.E. Huppert; Benjamin T. Cooper; M. Tam; Judith D. Goldberg; Carmen A. Perez; Silvia C. Formenti; Naamit K. Gerber


International Journal of Radiation Oncology Biology Physics | 2017

High Tangents in the Prone Position: A Pilot Report on Its Feasibility

F. Shaikh; M. Tam; C.A. Perez; N.E. Huppert; C. Hitchen; A. McCarthy; O.G. Maisonet; S.C. Formenti; Naamit K. Gerber


International Journal of Radiation Oncology Biology Physics | 2015

High-Dose Radiation Leads to Rapid Changes in Tumor Perfusion and Vascular Remodeling

Ashish Jani; F. Shaikh; Angela Kadenhe-Chiweshe; Sonia L. Hernandez; Tom K. Hei; Darrell J. Yamashiro; E.P. Connolly


International Journal of Radiation Oncology Biology Physics | 2014

Modeling Radiation-Induced Vascular Effects of High-Dose Versus Standard-Dose Radiation in an Orthotopic Mouse Model of High-Risk Neuroblastoma

F. Shaikh; Angela Kadenhe-Chiweshe; Sonia L. Hernandez; L.A. Forrester; Y. Sun; Tom K. Hei; Darrell J. Yamashiro; E.P. Connolly

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M. Tam

New York University

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Angela Kadenhe-Chiweshe

Columbia University Medical Center

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Darrell J. Yamashiro

Columbia University Medical Center

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E.P. Connolly

Columbia University Medical Center

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Naamit K. Gerber

Memorial Sloan Kettering Cancer Center

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