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Dive into the research topics where F Z Yetkin is active.

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Featured researches published by F Z Yetkin.


Neurology | 1993

Functional magnetic resonance imaging of complex human movements

Stephen M. Rao; Jeffrey R. Binder; Peter A. Bandettini; Thomas A. Hammeke; F Z Yetkin; Andrzej Jesmanowicz; L. M. Lisk; George L. Morris; Wade M. Mueller; Lloyd Estkowski; E. C. Wong; Victor M. Haughton; James S. Hyde

Functional magnetic resonance imaging (FMRI) is a new, noninvasive imaging tool thought to measure changes related to regional cerebral blood flow (rCBF). Previous FMRI studies have demonstrated functional changes within the primary cerebral cortex in response to simple activation tasks, but it is unknown whether FMRI can also detect changes within the nonprimary cortex in response to complex mental activities. We therefore scanned six right-handed healthy subjects while they performed self-paced simple and complex finger movements with the right and left hands. Some subjects also performed the tasks at a fixed rate (2 Hz) or imagined performing the complex task. Functional changes occurred (1) in the contralateral primary motor cortex during simple, self-paced movements; (2) in the contralateral (and occasionally ipsilateral) primary motor cortex, the supplementary motor area (SMA), the premotor cortex of both hemispheres, and the contralateral somatosensory cortex during complex, self-paced movements; (3) with less intensity during paced movements, presumably due to the slower movement rates associated with the paced (relative to self-paced) condition; and (4) in the SMA and, to a lesser degree, the premotor cortex during imagined complex movements. These preliminary results are consistent with hierarchical models of voluntary motor control.


Neurology | 1994

Relationship between frontal lobe lesions and Wisconsin Card Sorting test performance in patients with multiple sclerosis

Peter A. Arnett; Stephen M. Rao; Linda Bernardin; Jordan Grafman; F Z Yetkin; L. Lobeck

Conceptual reasoning deficits are common in patients with multiple sclerosis (MS) and are typically associated with focal lesions involving the frontal lobes. In this study, we predicted that MS patients with frontal white matter lesions (MS-F) would be more impaired on a standard conceptual reasoning task (Wisconsin Card Sorting Test; WCST) than patients with minimal frontal lesions (MS-NF), even if the total cerebral lesion area (TLA), measured from MRI, was equivalent across groups. We subdivided 43 definite MS patients into three groups based on MRI findings: seven in the MS-F group (mean TLA = 41.4 cm2) and seven in the MS-NF group (mean TLA = 50.0 cm2); 29 MS patients served as a low lesion burden control group (MS-C; mean TLA = 6.4 cm2). The groups did not differ with regard to demographic and illness characteristics. Although the three subgroups obtained comparable scores on a measure of global cognitive functioning (verbal intelligence), the MS-F group achieved significantly fewer categories and made more total errors on the WCST than did the MS-NF and MS-C groups. The MS-F group made significantly more perseverative responses than the MS-C group and nonsignificantly more than the MS-NF group. These results suggest that the pattern of cognitive decline in MS is a function of the location of demyelinating lesions within the cerebral hemispheric white matter. Finally, we supplement the group study results with a case report of an MS patient who was studied serially with MRI and cognitive testing.


Neurosurgery | 1994

Functional magnetic resonance imaging of somatosensory stimulation

Thomas A. Hammeke; F Z Yetkin; Wade M. Mueller; George L. Morris; Victor M. Haughton; Stephen M. Rao; Jeffrey R. Binder; C. J. Hodge; J. Schramm

Functional magnetic resonance imaging (FMRI) has detected changes in regional cerebral blood flow and volume in response to motor movements, visual stimuli, and auditory stimuli in each of their respective primary cortices. This experiment was conducted to determine whether signal changes in the somatosensory cortex secondary to tactile stimulation could be demonstrated. The palm of the right hand was periodically stimulated while the subject was undergoing echo-planar imaging with a 1.5-T magnetic resonance scanner equipped with local gradient and radio frequency coils. Sagittal and coronal images of 10- to 15-mm slice thickness were selected to include the postcentral gyrus and surrounding regions. Temporally correlated signal changes of 1% to 5% occurred in the peri-rolandic region in each of six subjects. The time course of signal changes was comparable to that found in other primary sensory and motor cortices. The results provide preliminary evidence of the sensitivity of FMRI to activation of the somatosensory cortex with tactile stimulation and support FMRI as a promising noninvasive technique for study of the functional organization and integrity of the cerebrum.


Epilepsia | 1994

Functional magnetic resonance imaging in partial epilepsy.

George L. Morris; Wade M. Mueller; F Z Yetkin; Victor M. Haughton; Thomas A. Hammeke; Sara J. Swanson; Stephen M. Rao; Andrzej Jesmanowicz; Lloyd Estkowski; Peter A. Bandettini; Eric C. Wong; James S. Hyde

Summary: Functional magnetic resonance imaging (FMRI) detects signal changes in brain that accompany regional changes in neuronal activity. In normal human brain, FMRI shows changes in signal in the postcentral gyrus or superior temporal gyrus that correlate with voluntary motor activity or language processing, respectively. The model used to explain the changes in signal linked temporally with cerebral activity is a reduction in cerebral capillary deoxyhemoglobin concentration due to the increased blood flow that accompanies neuronal activity in the cerebrum. FMRI has been used in normal subjects but not extensively in patients. To determine the feasibility of using FMRI to map cerebral functions in patients with partial epilepsy syndromes, we performed a pilot study, using FMRI to identify signal changes in motor and language areas in response to tasks that activate those areas. Signal changes in epilepsy patients approximated those observed in volunteers. We conclude that FMRI can be developed as a method for functional cerebral mapping in partial epilepsies.


Magnetic Resonance in Medicine | 1995

Functional connectivity in the motor cortex of resting human brain using echo‐planar mri

Bharat B. Biswal; F Z Yetkin; Victor M. Haughton; James S. Hyde


Annals of Neurology | 1994

Functional magnetic resonance imaging of human auditory cortex

Jeffrey R. Binder; Stephen M. Rao; Thomas A. Hammeke; F Z Yetkin; Andrzej Jesmanowicz; Peter A. Bandettini; Eric C. Wong; Lloyd Estkowski; M. D. Goldstein; Victor M. Haughton; James S. Hyde


American Journal of Neuroradiology | 1997

Functional MR activation correlated with intraoperative cortical mapping.

F Z Yetkin; Wade M. Mueller; George L. Morris; Timothy L. McAuliffe; John L. Ulmer; Robert W. Cox; D L Daniels; Victor M. Haughton


American Journal of Neuroradiology | 1998

Functional MR of Frontal Lobe Activation: Comparison with Wada Language Results

F Z Yetkin; Sara J. Swanson; M E Fischer; G. Akansel; George L. Morris; Wade M. Mueller; Victor M. Haughton


American Journal of Neuroradiology | 1995

A Comparison of Functional MR Activation Patterns during Silent and Audible Language Tasks

F Z Yetkin; Thomas A. Hammeke; Sara J. Swanson; George L. Morris; Wade M. Mueller; Timothy L. McAuliffe; Victor M. Haughton


American Journal of Neuroradiology | 1996

Test-retest precision of functional MR in sensory and motor task activation.

F Z Yetkin; Timothy L. McAuliffe; Robert W. Cox; Victor M. Haughton

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Victor M. Haughton

Medical College of Wisconsin

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George L. Morris

Medical College of Wisconsin

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Wade M. Mueller

Medical College of Wisconsin

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James S. Hyde

Medical College of Wisconsin

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M E Fischer

Medical College of Wisconsin

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R A Papke

Medical College of Wisconsin

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Robert W. Cox

National Institutes of Health

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Thomas A. Hammeke

Medical College of Wisconsin

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D L Daniels

Medical College of Wisconsin

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