Fabiana Elias

Cyclooxygenase Inhibitor Associated with Carboplatin in Treatment of Metastatic Nasal Carcinoma in Dog

A 10-year-old, intact male, pinscher was presented with unilateral bloodstained nasal discharge, sneezing, dyspnea, zygomatic arch deformity, submandibular lymph node increase, blindness in right eye, and exophthalmia. After clinical examination, it was found that the animal presented with upper respiratory tract dyspnea origin, possibly caused by an obstructive process. Complete blood count (CBC), ocular ultrasonography, thoracic radiographs, mandibular lymph node, and nasal sinus fine needle aspiration were performed. The right mandibular lymph node excisional biopsy was conducted and a tumor sample was obtained through the nasal fistula at hard palate. The material was processed, paraffin embedded, sectioned, and stained with hematoxylin and eosin. Immunohistochemical staining for cytokeratin (AE1/AE3), vimentin, and COX-2 was performed. After histopathological evaluation nasal carcinoma diagnosis was obtained. Chemotherapy was established with carboplatin 300u2009mg/m2 intravenously—four cycles with intervals of 21 days—and firocoxib 5u2009mg/kg orally every 24 hours for 7 months. After 7 months the treatment started, the animal presented with ataxia, vocalization, hyperesthesia, and anorexia. Due the clinical condition presented, the animal owner opted for performing euthanasia. The chemotherapy protocol was effective causing the disease stagnation, minimizing the clinical signs, and extending patient survival and quality of life.

Aspectos clínico-patológicos da gastrite ulcerativa em gatos associadas uso de anti-inflamatórios não esteroides

Stomach ulcers are commun in small animal practice and occurs commonly in dogs due administration of nonsteroidal anti-inflammatory drugs (NSAIDs). It is an often silent disease, difficult to diagnose and with serious consequences to health of the animal. Although well documented in dogs, there are few reports of ulcers associated with the use of NSAIDs in cats. This paper describes the death of three cats as a result of perforated ulcer and secondary peritonitis associated with NSAIDs administration. There were holes in the stomach pyloric region with white and rounded edges, and large amount of fluid in the abdominal cavity, hyperemia, the presence of fibrin. Although not commonly reported the occurrence of gastrointestinal ulcers in cats, it appears that these have been caused by the effect of prolonged administration and inadequate doses of NSAIDs.