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Dive into the research topics where Fabien Zunino is active.

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Featured researches published by Fabien Zunino.


Organic Letters | 2010

Superelectrophilic activation in superacid HF/SbF(5) and synthesis of benzofused sultams.

Fei Liu; Agnès Martin-Mingot; Marie-Paule Jouannetaud; Fabien Zunino; Sébastien Thibaudeau

The synthesis of benzofused sultams and/or fluorinated sulfonamides, starting from N-allylic sulfonamides, was performed in superacid HF/SbF(5), through superelectrophilic activation. A dramatic effect of superacid composition on the selectivity of the reaction was shown and applied to the synthesis of cyclic 4-aminobenzenesulfonamides.


Chemical Communications | 2007

A novel, facile route to beta-fluoroamines by hydrofluorination using superacid HF-SbF(5).

Sébastien Thibaudeau; Agnès Martin-Mingot; Marie-Paule Jouannetaud; Omar Karam; Fabien Zunino

A range of unsaturated amines and sulfonamides were converted to beta-fluoro nitrogen analogues after hydrofluorination in superacid HF-SbF(5), based on the formation of highly reactive electrophilic intermediates.


Journal of Organic Chemistry | 2011

Selective synthesis of gem-chlorofluorinated nitrogen-containing derivatives after superelectrophilic activation in superacid HF/SbF5.

Fei Liu; Agnès Martin-Mingot; Marie-Paule Jouannetaud; Christian Bachmann; Gilles Frapper; Fabien Zunino; Sébastien Thibaudeau

The first direct selective synthesis of novel gem-chlorofluorinated nitrogen-containing building blocks in superacid is reported. The dramatic role of the chlorine atom on the reaction is shown by in situ NMR experiments and allows the involvement of a novel original superelectrophilic activation process in superacid HF/SbF(5) to be postulated.


Tetrahedron | 1998

Functionalization of a non activated CH bond: Fluorination of vindoline at C-20 in superacids

Christian Berrier; Jean-Claude Jacquesy; Marie-Paule Jouannetaud; Ce´cile Lafitte; Yves Vidal; Fabien Zunino; Jacques Fahy; Alain Duflos

Abstract Reaction of vindoline 1a with NBS, NCS, H 2 O 2 in HF-SbF 5 yields 7β substituted (Br, Cl or OH)-20-fluoro-6,7-dihydrovindolines. These results imply reaction of the electrophile (Br + , Cl + and OH + equivalent) on the β-face of C-6 C-7 double bond to give oniums ions, followed by a 1,3-hydride shift from C-20 to C-6, and fluorination of the resulting ion.


Tetrahedron Letters | 2003

An efficient synthesis of 6-hydroxymelatonin, a human metabolite of melatonin

Omar Karam; Fabien Zunino; Vincent Chagnaut; Marie Paule Jouannetaud; Jean Claude Jacquesy

Abstract A four-step synthesis of 6-hydroxymelatonin 5 , major human metabolite of melatonin 1 , is reported starting from melatonin. The synthesis involves in the keys steps a regioselective Friedel–Crafts acylation followed by a Baeyer–Villiger oxidation. The overall yield is 48%.


Journal of the American Chemical Society | 1997

Vinca Alkaloids in Superacidic Media: A Method for Creating a New Family of Antitumor Derivatives

Jacques Fahy; Alain Duflos; Jean-Paul Ribet; Jean-Claude Jacquesy; C. Berrier; § and Marie-Paule Jouannetaud; Fabien Zunino


Archive | 1994

Antimitotic binary alkaloid derivatives from catharanthus roseus

Jean-Claude Jacquesy; Jacques Fahy; C. Berrier; Dennis Bigg; Marie-Paule Jouannetaud; Fabien Zunino; Anna Kruczynski; Robert Kiss


Archive | 1994

Novel antimitotic binary alkaloid derivatives extracted from catharanthus roseus

Jean-Claude Jacquesy; Jacques Fahy; C. Berrier; Dennis Bigg; Marie-Paule Jouannetaud; Fabien Zunino; Anna Kruczynski; Robert Kiss


Journal of Fluorine Chemistry | 2008

Gem-difluorination in superacid: The dramatic role of halonium ions

Fabien Zunino; Fei Liu; Christian Berrier; Agnès Martin-Mingot; Sébastien Thibaudeau; Marie-Paule Jouannetaud; Jean-Claude Jacquesy; Christian Bachmann


Archive | 2002

DIHYDROIMIDAZO [5,1-A]-

Jean-Bernard Fourtillan; Marianne Fourtillan; Omar Karam; Fabien Zunino; Jean-Claude Jacquesy; Jean-Pierre Tafani

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Omar Karam

Centre national de la recherche scientifique

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C. Berrier

Centre national de la recherche scientifique

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Jacques Fahy

Centre national de la recherche scientifique

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Robert Kiss

Université libre de Bruxelles

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Jean Claude Jacquesy

Centre national de la recherche scientifique

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Dennis Bigg

Centre national de la recherche scientifique

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