Fabrice Vergne | Researchain

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Archive | 2005

3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands

Patrick Bernardelli; Andrew Michael Cronin; Alexis Denis; Stephen Martin Denton; Henry Jacobelli; Mark Ian Kemp; Edwige Lorthiois; Fiona Rousseau; Delphine Serradeil-Civit; Fabrice Vergne

Bioorganic & Medicinal Chemistry Letters | 2004

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies

Fabrice Vergne; Patrick Bernardelli; Edwige Lorthiois; Nga Pham; Emmanuelle Proust; Chrystelle Oliveira; Abdel-Kader Mafroud; Frederique Royer; Roger Wrigglesworth; Jennifer K. Schellhaas; Mark Robert Barvian; François Moreau; Moulay Idrissi; Anita Tertre; Bernadette Bertin; Magali Coupe; Patrick Berna; Patricia Soulard

Archive | 2002

Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors

Patrick Bernardelli; Pierre Ducrot; Edwige Lorthiois; Fabrice Vergne

Archive | 2003

Spirocondensed quinazolinones and their use as phosphodiesterase inhibitors

Patrick Bernardelli; Fabrice Vergne; Chrystelle Uk Patent Dept Pfizer Limted Mendes; Pierre Ducrot

Bioorganic & Medicinal Chemistry Letters | 2004

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1

Edwige Lorthiois; Patrick Bernardelli; Fabrice Vergne; Chrystelle Oliveira; Abdel-Kader Mafroud; Emmanuelle Proust; Lamia Heuze; François Moreau; Moulay Idrissi; Anita Tertre; Bernadette Bertin; Magali Coupe; Roger Wrigglesworth; Arnaud Descours; Patricia Soulard; Patrick Berna

Bioorganic & Medicinal Chemistry Letters | 2004

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives

Fabrice Vergne; Patrick Bernardelli; Edwige Lorthiois; Nga Pham; Emmanuelle Proust; Chrystelle Oliveira; Abdel-Kader Mafroud; Pierre Ducrot; Roger Wrigglesworth; Françoise Berlioz-Seux; Francis Coleon; Eric Chevalier; François Moreau; Moulay Idrissi; Anita Tertre; Arnaud Descours; Patrick Berna; Mei Li

Bioorganic & Medicinal Chemistry Letters | 2004

Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives

Patrick Bernardelli; Edwige Lorthiois; Fabrice Vergne; Chrystelle Oliveira; Abdel-Kader Mafroud; Emmanuelle Proust; Nga Pham; Pierre Ducrot; François Moreau; Moulay Idrissi; Anita Tertre; Bernadette Bertin; Magali Coupe; Eric Chevalier; Arnaud Descours; Françoise Berlioz-Seux; Patrick Berna; Mei Li

Archive | 2001