Fahri Adali
Pamukkale University
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Featured researches published by Fahri Adali.
Surgery Today | 2011
Zafer Teke; Fahri Adali; E. Canan Kelten; Yasar Enli; K. Gokhan Sackan; Kerem Karaman; Metin Akbulut; Ibrahim Goksin
PurposeMannitol is used as a treatment for ischemia/reperfusion (IR) injury of various organs in humans, despite the fact that its effectiveness in vivo is still disputed. The purpose of this study was to determine the effects of mannitol on acute lung injury (ALI) induced by infrarenal aortic occlusion.MethodsMale Wistar-albino rats were allocated into five groups: (i) sham-operated group, which received a laparotomy without IR injury (n = 12); (ii) IR group, which received 3 h of ischemia followed by 2 h of reperfusion (n = 12); (iii) IR + inferior caval phlebotomy (ICP) group, which was identical to group 2 except for 1 ml of blood aspiration from the inferior caval vein (n = 12); (iv) IR + mannitol-treated group, for which rats were subjected to IR and received a bolus injection of mannitol (n = 12); and (v) IR + ICP + mannitol-treated group, which underwent the same procedures as described for the previous groups. Arterial blood gas parameters were studied and bronchoalveolar lavage (BAL) was performed. Evans blue dye was injected into half of the rats. We biochemically assessed the degree of pulmonary tissue injury by investigating oxidative stress markers and enzymatic and nonenzymatic antioxidant markers, and evaluated ALI by establishing pulmonary leukosequestration and ALI scoring, histopathologically. Pulmonary edema was estimated by using Evans blue dye extravasation and wet/dry weight ratios.ResultsHypertonic mannitol treatment significantly reduced oxidative stress markers, and significantly increased enzymatic and nonenzymatic antioxidant markers in the lung tissues (P < 0.05). Arterial blood gas parameters were significantly ameliorated (P < 0.05), the BAL cytology was significantly better (P < 0.05), pulmonary leukosequestration and ALI scores were significantly decreased (P < 0.05), and pulmonary edema was significantly alleviated (P < 0.05) by mannitol administration.ConclusionThis study clearly showed that mannitol treatment significantly attenuated the aortic IR-induced ALI. Further clinical studies are required to clarify whether mannitol has a useful role in ALI during surgeries in which IR-induced organ injury occurs.
Journal of Surgical Research | 2005
Mustafa Saçar; Ibrahim Goksin; Ahmet Baltalarli; Huseyin Turgut; Suzan Sacar; Gökhan Önem; Vefa Ozcan; Fahri Adali
Annals of Vascular Surgery | 2011
Ibrahim Goksin; Fahri Adali; Yasar Enli; Metin Akbulut; Zafer Teke; Gokhan Sackan; Erkin Ocak; Ali Vefa Özcan
Texas Heart Institute Journal | 2010
Mustafa Saçar; Suzan Sacar; Nural Cevahir; Gökhan Önem; Zafer Teke; Ali Asan; Huseyin Turgut; Fahri Adali; Ilknur Kaleli; Ibrahim Susam; Yalin Tolga Yaylali; Ahmet Baltalarli
Journal of Academic Emergency Medicine Case Reports | 2014
İhsan Alur; I. Dogu Kilic; Fahri Adali; Hayati Tastan; Tevfik Güneş; Ibrahim Goksin
Archive | 2011
Mustafa Saçar; Gökhan Önem; Fahri Adali
Annales De Chirurgie Vasculaire | 2011
Ibrahim Goksin; Fahri Adali; Yasar Enli; Metin Akbulut; Zafer Teke; Gokhan Sackan; Erkin Ocak; Ali Vefa Özcan
AJCI | 2011
İbrahim Susam; Yalin Tolga Yaylali; Münevver Dereli; Mustafa Saçar; Gökhan Önem; İbrahim Gökşin; Fahri Adali
The Anatolian journal of cardiology | 2010
Ali Vefa Özcan; Ahmet Baltalarli; Fahri Adali; Bilgin Emrecan; Serper Pazarcikci
Archive | 2010
Mustafa Saçar; Suzan Sacar; Nural Cevahir; Gökhan Önem; Zafer Teke; Ali Asan; Huseyin Turgut; Fahri Adali; Ilknur Kaleli; İbrahim Susam; Yalin Tolga Yaylali; Ahmet Baltalarli