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Dive into the research topics where Faiz A. Cheema is active.

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Featured researches published by Faiz A. Cheema.


Circulation | 2005

Irbesartan and Lipoic Acid Improve Endothelial Function and Reduce Markers of Inflammation in the Metabolic Syndrome Results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) Study

Srikanth Sola; Muhammad Q.S. Mir; Faiz A. Cheema; Nadya Khan-Merchant; Rekha G. Menon; Sampath Parthasarathy; Bobby V. Khan

Background—The metabolic syndrome is associated with increased angiotensin II activity, induction of a proinflammatory and oxidative state, and endothelial dysfunction. We evaluated the ability of irbesartan, an angiotensin receptor blocker, and lipoic acid, an antioxidant, to affect endothelial function and inflammation in patients with the metabolic syndrome. Methods and Results—We randomized 58 subjects with the metabolic syndrome in a double-blinded manner to irbesartan 150 mg/d (n=14), lipoic acid 300 mg/d (n=15), both irbesartan and lipoic acid (n=15), or matching placebo (n=14) for 4 weeks. Endothelium-dependent and -independent flow-mediated vasodilation was determined under standard conditions. Plasma levels of interleukin-6, plasminogen activator-1, and 8-isoprostane were measured. After 4 weeks of therapy, endothelium-dependent flow-mediated vasodilation of the brachial artery was increased by 67%, 44%, and 75% in the irbesartan, lipoic acid, and irbesartan plus lipoic acid groups, respectively, compared with the placebo group. Treatment with irbesartan and/or lipoic acid was associated with statistically significant reductions in plasma levels of interleukin-6 and plasminogen activator-1. In addition, treatment with irbesartan or irbesartan plus lipoic acid decreased 8-isoprostane levels. No significant changes in blood pressure were noted in any of the study groups. Conclusions—Administration of irbesartan and/or lipoic acid to patients with the metabolic syndrome improves endothelial function and reduces proinflammatory markers, factors that are implicated in the pathogenesis of atherosclerosis.


American Heart Journal | 2008

Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men

Rachel Lampert; J. Douglas Bremner; Shaoyong Su; Andrew H. Miller; Forrester A. Lee; Faiz A. Cheema; Jack Goldberg; Viola Vaccarino

BACKGROUND Many traditional risk factors for coronary artery disease (CAD) are associated with altered autonomic function. Inflammation may provide a link between risk factors, autonomic dysfunction, and CAD. We examined the association between heart rate variability (HRV), a measure of autonomic function, and inflammation, measured by C-reactive protein (CRP) and interleukin-6 (IL-6). METHODS We examined 264 middle-aged male twins free of symptomatic CAD. All underwent ambulatory electrocardiogram monitoring and 24-hour ultra low, very low, low, and high-frequency power were calculated using power spectral analysis. C-reactive protein and IL-6 were measured, and risk factors including age, smoking, hypertension, lipids, diabetes, body mass index (BMI), depression, and physical activity were assessed. RESULTS Physical activity, BMI, high-density lipoprotein cholesterol, smoking, depression, and hypertension were directly associated with CRP and IL-6 and inversely associated with one or more HRV variables. There was a graded inverse relationship between all HRV parameters (except high frequency) and CRP and IL-6. After adjustment for age, BMI, activity, high-density lipoprotein, smoking, hypertension, depression, and diabetes, ultra low frequency and very low frequency remained significant predictors of CRP (P < .01). CONCLUSIONS C-reactive protein is associated with decreased HRV, even after controlling for traditional CAD risk factors. Autonomic dysregulation leading to inflammation may represent one pathway through which traditional risk factors promote development of CAD.


Journal of Thrombosis and Haemostasis | 2007

Heritability of flow-mediated dilation: a twin study.

Jinying Zhao; Faiz A. Cheema; U. Reddy; J. D. Bremner; Shaoyong Su; Jack Goldberg; Harold Snieder; Viola Vaccarino

Summary.  Background: Endothelial dysfunction assessed by brachial artery flow‐mediated dilation (FMD) is a marker for early atherosclerotic vascular disease and future cardiovascular events.


Atherosclerosis | 2008

Heritability of carotid intima-media thickness: A twin study

Jinying Zhao; Faiz A. Cheema; J. Douglas Bremner; Jack Goldberg; Shaoyong Su; Harold Snieder; Carisa Maisano; Linda Jones; Farhan Javed; Nancy Murrah; Ngoc Anh Le; Viola Vaccarino


Preventive Cardiology | 2007

The Role of Quinapril in the Presence of a Weight Loss Regimen: Endothelial Function and Markers of Obesity in Patients With the Metabolic Syndrome

Sameer Nagamia; Anbu Pandian; Faiz A. Cheema; Rama Natarajan; Qamar A Khan; Amar D. Patel; Nadya Merchant; Srikanth Sola; Bobby V. Khan


Stress and Health | 2009

Effects of a cognitive stress challenge on myocardial perfusion and plasma cortisol in coronary heart disease patients with depression

James D. Bremner; Faiz A. Cheema; Ali Ashraf; Nadeem Afzal; Negar Fani; Lai Reed; James C. Ritchie; Tracy L. Faber; John R. Votaw; Charles B. Nemeroff; Viola Vaccarino


Journal of The Cardiometabolic Syndrome | 2008

Effects of Angiotensin-Converting Enzyme Inhibitor Therapy on Levels of Inflammatory Markers in Response to Exercise-Induced Stress: Studies in the Metabolic Syndrome

Christopher S. Vaccari; Syed T. Rahman; Qamar A Khan; Faiz A. Cheema; Bobby V. Khan


Preventive Cardiology | 2006

Cocaine Use in an Urban Medical Population and the Development of Angiographically Significant Coronary Artery Disease

Amar D. Patel; Srikanth Sola; Patrick M. Caneer; Faiz A. Cheema; Divya Gupta; Tarek Helmy; Bobby V. Khan


Circulation | 2006

Abstract 4145: Effects of Statin and Niacin Therapy on Flow Mediated Dilation and High Sensitivity C-reactive Protein in Patients with the Metabolic Syndrome

Faiz A. Cheema; Asahiko Oguchi; Nadya Merchant; Guillermo E. Umpierrez; Allen Dollar; Bobby V. Khan


Atherosclerosis | 2008

Heritability of carotid intima-media thickness

Jinying Zhao; Faiz A. Cheema; J. Douglas Bremner; Jack Goldberg; Shaoyong Su; Harold Snieder; Carisa Maisano; Linda Jones; Farhan Javed; Nancy Murrah; Ngoc Anh Le; Viola Vaccarino

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Jack Goldberg

University of Washington

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Shaoyong Su

Georgia Regents University

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