Farah Saeed

Evaluation of neuro-pharmacological activities in six homeopathic drugs

Farah-Saeed*, Noor-Jahan, Mehjabeen and Mansoor Ahmad Department of Pharmacognosy, Dow College of Pharmacy, Dow University of Health Sciences, Karachi-Pakistan. Department of Pharmacology, Dow College of Pharmacy, Dow University of Health Sciences, Karachi-Pakistan. Department of Pharmacology, Faculty of Pharmacy, Federal Urdu University of Arts Science and Technology, KarachiPakistan. Research Institute of Pharmaceutical Sciences, University of Karachi-Pakistan.

NOVEL INVESTIGATIONS ON THUJA OCCIDENTALIS EXTRACT ON RABBIT HEMATOLOGI CAL AND BIOCHEMICAL PARAMETERS

Thuja occidentalis (family: Cupressaceae) has been used as antiseptic, expectorant, diuretic and in the treatme nt of cancer and removal of kidney stones in different system s of medicine . Th e present studies were carried out on T. occidentalis leaves extract to evaluate the h ematological and biochemical effects on rabbit s . The animals were divided in to control (A a nd B) and treated (C and D) male and female groups ( n= 5). T here was a slight decrease in Hemoglobin, Red blood cell count and Hematocrit/Packed cell volume values, while a significant increase in platelet count was observed in male and female treated group s . However, slight increase in total leukocyte count value in male treated group and decrease count with female treated group wa s also observed. Urea, Creatine phospho kinase, Creatine phospho kinase iso - enzyme, Direct Bilirubin, Gamma - glutamyl transpeptid ase , Cholesterol and Albumin/Globulin ratio values were elevated in male treated group . While Phosphorus, Uric acid, Lactate dehydrogenase , Serum glutamic oxaloacetic transaminase , serum glutamic - pyruvic transaminase , Alkaline Phosphatase, Cholesterol, Tri glycerides, High density lipoprotein, Low density lipoprotein, Very - low - density lipoprotein , Globulin and Blood Glucose values were found low . In female treated group almost same results were observed like male treated group except th at hypoglycemic effect was more pronounced in female treated group. These findings suggested that when results of hematological and biochemical parameters of test groups (C & D) were compared with their respective controls (A & B), significant changes were observed which contr ibutes towards the diversified therapeutic effect of T. occidentalis .

Anti-diabetic and acute toxicity studies of Annona squamosa L. ethanolic leaves extract.

Abstract Aim of this research work was to explore the anti-diabetic activity and acute toxicity of Annona squamosa L. leaves ethanolic extract in albino rats and mice respectively. Diabetes was induced by Alloxan (120 mg/kg). Seven rats were taken in each group. Glibenclaimide (0.25 mg/kg) was taken as the standard drug. A. squamosa was administered orally in 100mg, 200mg and 400mg doses in three different groups of diabetes- induced rats. A. squamosa leaves extracts were found to have significant anti-diabetic activity. Acute toxicity study was carried out on administration of 800mg/kg, 1600mg/kg and 5000 mg/kg body weight. No acute toxicity was observed at 800mg/kg and 1600mg/kg doses. At 5000mg/kg body weight dose 100% fatality was recorded within 24 hours. Our research work revealed the safe and effective anti-diabetic activity of Annona squamosa ethanolic leaves extract.