Farkhanda Shaheen

1-Methyl-1H-benzimidazole-2(3H)-thione.

The title compound, C8H8N2S, was prepared by the condensation of N-methyl-1,2-phenylenediamine and carbon disulfide. The crystal structure is stabilized by a C—H⋯π interaction between a benzene H atom and the benzene ring of a neighbouring molecule, and by intermolecular N—H⋯S interactions.

[(Methyl-carbamothio-yl)disulfan-yl]methyl N-methyl-carbamodithio-ate.

The title compound, C5H10N2S5, was unintentionally obtained as the product of an attempted synthesis of a methylcarbamodithioic acid using methylamine and carbon disulfide. In the molecule, two dithiocarbamate groups are bridged by a –CH2S– unit. The C—S—S—C torsion angle is −90.13 (11)°. The crystal structure is stabilized by N—H⋯S interactions between neighbouring molecules. An intramolecular N—H⋯S hydrogen bond also occurs.

3-(4-Chloro-phen-yl)-2-methyl-acrylic acid.

In the crystal structure of the title compound, C10H9ClO2, dimers form as a result of intermolecular O—H⋯O bonding. These dimers are linked to each other via C—H⋯O bonds, where the CH group belongs to the benzene ring and the O atom is from the carbonyl group of an adjacent molecule. There exist two intermolecular C—H⋯O hydrogen bonds, which individually form five-membered rings. There also exists a π–π interaction between the aromatic ring and its symmetry counterpart, with a centroid–centroid distance of 4.0202 (17) Å, and a C—H⋯π interaction between a methyl CH group and the aromatic ring.

Synthesis, Spectral and In Vitro Biological Studies of Bis‐Triorganogermyl(substituted)propionates of Triarylantimony(V) X‐ray Studies of Triphenylgermyl‐n‐propyl Propionic Acid

New compounds of Bis‐triorganogermyl(substituted) propionates of triarylantimony(V) with general formula (1R3-GeCHR2CH2CO2)2SbAr3 have been synthesized and characterized by various techniques such as elemental analyses; FT‐IR, 1HNMR, 13CNMR and mass spectrometry. All these compounds have distorted trigonal bipyramidal geometry around antimony in both solid states as well as in non‐coordinated solvents. The single X‐ray analysis of precursor triphenylgermyl‐n‐propyl propionic acid (Ph3GeCH‐(n‐C3H7)CH2COOH) have revealed dimeric structure of molecule through strong hydrogen bonding in conventional manner in which germanium has slightly distorted tetrahedral geometry. Selected numbers of compounds screened against different strains of bacteria and fungus show good activity.

Chloro­(4-methylpiperidine-1-dithio­carbamato-κ2S:S′)(triphenyl­phosphine-κP)palladium(II)

In the title compound, [Pd(C7H12NS2)Cl(C18H15P)], the Pd atom is four-coordinate and exhibits a slightly distorted square-planar geometry.

Synthesis, Characterization, and Anticancer Activity of Organotin(IV) Complexes with Sodium 3-(1H-Indol-3-yl)propanoate

Six organotin(IV) complexes have been synthesized by refluxing sodium salt of 3-(1H-indol-3-yl)-propanoic acid with di- and triorganotin chlorides in 1: 1 and 2: 1 molar ratios, respectively. These complexes have been characterized by elemental analysis, IR, and 1H, 13C, and 119Sn NMR spectral data. DNA binding studies were performed by viscometric measurements and UV-Vis spectroscopy. Both techniques indicated an intercalation mode of interaction. Cytotoxic activity of the ligand salt and organotin(IV) complexes 1–6 was tested against human ovarian cell line A2780. Results of bioassay revealed that organotin derivatives were more active than anticancer drug cis-platin. Triorganotin(IV) compounds had higher cytotoxic activity than corresponding diorganotin(IV) complexes.