Farzana Mahomed

Adenomatoid odontogenic tumor (AOT) originating in a unicystic ameloblastoma: a case report.

The follicular variant of the adenomatoid odontogenic tumor (AOT) is thought to originate from the reduced enamel epithelium of the dental follicle. The origin of the extra-follicular variant however, remains less clear. This paper presents a case of an extra-follicular AOT, which we believe originated from the epithelial lining of a unicystic ameloblastoma, and reviews the literature. The available evidence seems to indicate that some extra-follicular AOTs might arise as secondary phenomena within pre-existing odontogenic cysts or cystic tumors.

Neuroendocrine cells and associated malignancies of the oral mucosa: a review.

Neuroendocrine cells of the oral mucosa constitute an under-recognized component of the diffuse neuroendocrine system with diverse subpopulations and elusive biologic roles in the oral cavity. Primary malignant oral tumors that show a neuroendocrine phenotype display histomorphologic heterogeneity thereby giving rise to a spectrum of lesions in this rare category of oral malignancy. These lesions can be divided into neuroendocrine carcinomas (NECs) of small cell or non-small cell type. The former is further subdivided into the Merkel cell type or the pulmonary type while the latter includes atypical carcinoid tumor and large cell NEC. All histologic subtypes of oral NEC appear to have a strong predilection for men in their fifth or sixth decade and arise predominantly in the non-keratinized oral mucosa. The biologic behavior of oral Merkel cell carcinomas appears to be more aggressive than those of skin. It remains to be determined whether histologic categorization of the remaining tumor subtypes is predictive of patient survival in oral neuroendocrine tumors.

Recent advances in mucin immunohistochemistry in salivary gland tumors and head and neck squamous cell carcinoma

This review focuses on the immunohistochemical expression of members of the MUC-type mucin family in salivary gland tumors and head and neck squamous cell carcinomas (HNSCC). Information is available on changes in the expression levels and distribution profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6 and MUC7 in tumors of the salivary glands; and of MUC1, MUC2 and MUC4 in HNSCC. In salivary gland tumors the expression patterns of MUC2, MUC3, MUC5AC and MUC6 appear to be very closely correlated with the histopathological tumor type indicating their potential use to improve diagnostic accuracy in salivary gland neoplasia. Some MUC-type mucins have emerged as valuable prognostic indicators in pleomorphic adenoma, mucoepidermoid carcinoma and HNSCC. Nine antibodies directed against different MUC1 antigens have thus far been examined in HNSCC of which monoclonal antibodies DF3, HMFG-1 and Ma695 have shown significant correlations with disease outcome. The importance of taking the specific anti-MUC antibody into consideration when comparing the results of different studies on MUC expression in salivary gland tumors and HNSCC is also highlighted in this review.

A rare case of lymphoepithelial carcinoma of the lip

Lymphoepithelial carcinoma (LEC) is a rare category of malignant neoplasms that share morphologic features with undifferentiated nasopharyngeal carcinoma, which can be regarded as the prototype Epstein-Barr virus (EBV)-positive epithelial neoplasm. A similar association with EBV is emerging for LEC of the oral cavity, which appears to be strongly influenced by the ethnic origin of the patient. A rare case of primary LEC of the lower lip in a 73-year-old Caucasian man is described. The tumor showed a striking microscopic resemblance to undifferentiated nasopharyngeal carcinoma (lymphoepithelioma) with features of a syncytial growth pattern, large undifferentiated tumor cells with vesicular nuclei, prominent eosinophilic nucleoli, and a dense intratumoral lymphocytic infiltrate. There was, however, no evidence of EBV infection of the tumor cells by immunohistochemistry and polymerase chain reaction, suggesting that EBV probably does not play a role in the pathogenesis of LEC of the lip in Caucasian patients.

Central adenoid cystic carcinoma of the mandible with odontogenic features: Report of a case

Primary intraosseous salivary‐type adenocarcinomas are rare neoplasms of uncertain histogenesis. The prevailing theories suggest origin from heterotopic salivary glands, odontogenic rests, or cystic epithelium.

Subcutaneous Calcinosis as Late Sequela of Radiotherapy to the Neck

r g The late adverse effects after radiotherapy to the head and neck region include radiation-induced malignancy and changes in the irradiated tissues, leading to chronic xerostomia, radiation caries, osteoradionecrosis, trismus, and dysphagia. Cranial nerve palsy, ocal cord palsy, sensorineural hearing loss, laryngeal steochondronecrosis, extracranial carotid stenosis, adiation myelopathy, and meningioma have also een reported as head and neck postirradiation seuelae. Radiotherapy can also induce dystrophic calcification by causing tumor necrosis and thus providing the milieu necessary for calcification. Although the data are replete with this form of dystrophic calcium deposition that occurs within the tumor after radiotherapy for various malignancies, heterotopic calcification in the subcutaneous tissue, also known as subcutaneous calcinosis, occurs far less frequently as a part of the late effects of radiotherapy. This form of dystrophic calcification develops after a long period of postirradiation latency. It is limited to the subcutaneous tissue and is linked to the late radiation effects of the overlying skin, notably cutaneous atrophy, telangiectasias, depigmentation, fibrosis, and cutaneous fistulas. The development of subcutaneous alcinosis as a late sequel of radiotherapy was first escribed in 1987 by Vainright et al and has since een described predominantly after chest wall irradition for breast cancer. To our knowledge, this is he first report to document the occurrence of this