Fateh Ali Tipoo Sultan

Tuberculous endocarditis: valvular and right atrial involvement

Valvular endocarditis due to Mycobacterium tuberculosis is a rare clinical entity. It is usually manifest in the context of disseminated tuberculosis in immunocompromised patients. This report describes a unique case of a 30-year-old immunocompetent man with an incidental finding of tuberculous valvular endocarditis. The patient had a large mass on the anterior mitral leaflet and severe mitral regurgitation. He underwent mitral valve replacement and Mycobacterium tuberculosis was cultured from the valve vegetation and the right atrial masses. Post-operative recovery has been uneventful without relapse for 24 months.

Paradoxical Thrombus ‘Caught in the Act’: Case Report and Review of the Literature

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Arrhythmogenic right ventricular cardiomyopathy with biventricular involvement and heart failure in a 9-year old girl.

-see front matter 2016 Elsevier Inc. All rights reserved. CASE REPORT A 70-year-old man presented with dyspnea on exertion and left leg swelling. Doppler ultrasound revealed a deep venous thrombosis. Medical history was notable for previous right lower extremity deep vein thrombosis, managed with oral anticoagulation. A transthoracic echocardiogram showed freely mobile masses within both atria, dilatation of the right-heart, and moderate pulmonary artery hypertension. Transesophageal echocardiography (TEE) confirmed large, serpentine-like thrombi straddling the patent foramen ovale (Figure). The patient declined surgical thrombectomy in

Clinical features, management and outcome of patients with constrictive pericarditis – Experience from a third world country

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is seldom recognized clinically in infancy or under the age of 10. We report a case of a 9-year-old girl with ARVC, who presented with signs and symptoms of heart failure and palpitations. Holter monitoring showed frequent premature ventricular beats and echocardiogram revealed dilated and dysfunctional right ventricle with normal tricuspid valve and no evidence of intracardiac shunt. Cardiac magnetic resonance showed classical features of ARVC with both ventricular involvements. After optimization of medical treatment the patient was referred for ICD implantation.

Unusual presentation of a young man with disseminated tuberculosis and right ventricular mass

Objectives To study the clinical features, management and outcome of patients with constrictive pericarditis, at a tertiary care hospital of Pakistan. Design Descriptive study. Material & method All consecutive patients with the final diagnosis of constrictive pericarditis, admitted at Aga Khan University Hospital Karachi, during the year 2005 to 2015 were included in the study. Results A total of 21 patients were diagnosed and managed as constrictive pericarditis during the above mentioned period. Mean age was 39 + 19.9 years. There was a male preponderance with a male to female ratio of 2.5:1.The most common clinical features were those of right heart failure. Only 2 (9.5%) patients showed pericardial calcification on X-ray chest. Dilated atria and septal bounce were the most common echo features present in 15 (71.4%). MRI/CT was done in only 11 patients, of which eight showed increased pericardial thickness. Three had normal pericardial thickness on MRI/CT but were proved to have constriction surgically. Cardiac catheterization was done in nine patients only. Elevated filling pressures and square root sign were the most common findings, present in all (100%). Pericardiectomy was performed in 12 (57%) patients. Five more patients were advised surgery but two died before the surgery and three were taken to other hospitals as they wanted to explore other options beside surgery. Pericardial tissue histopathology was available in only 11 patients. It revealed tuberculosis in three cases, while in 8 cases it was nonspecific. Six patients died with an overall mortality of 28.6%. Five patients died during hospitalization, four without surgery and one after the surgery. One patient died during follow up (was considered unfit for the surgery). Mean follow up duration was 7.3 + 9.3 months. No death occurred on follow up in surgically treated patients. Conclusion Features of right heart failure is the most common mode of presentation of CP. The most probable etiology in this part of the world is tuberculosis, although difficult to prove on histopathology. Pericardiectomy is the usual recommended treatment due to advanced disease at the time of presentation.

Aneurysm of sinus of Valsalva.

We report a 22-year-old man who presented to the emergency department with worsening shortness of breath and chronic fever for 2 months. Physical examination was unremarkable except for raised jugular venous pressure and palpable liver. Echocardiogram showed a large right ventricular mass causing obstruction at tricuspid valve. A subsequent chest CT scan confirmed the presence of a large mass in the right ventricle. There were multiple enlarged lymph nodes and consolidation in the right upper lobe. Diagnosis of disseminated tuberculosis (TB) was made and later confirmed by histopathology of lymph node biopsy along with positive sputum culture for acid-fast bacilli. Remarkable recovery was observed on antituberculous therapy, with complete disappearance of the cardiac mass on echocardiogram, at 1-year follow-up. Although unusual and rare, myocardial involvement as a large mass should be kept in mind while treating patients with disseminated TB.