Fateh V. Singh
Central Drug Research Institute
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Publication
Featured researches published by Fateh V. Singh.
Bioorganic & Medicinal Chemistry Letters | 2009
Fateh V. Singh; Amrita Parihar; Sumit Chaurasia; Amar Bahadur Singh; Salil P. Singh; Akhilesh K. Tamrakar; Arvind K. Srivastava; Atul Goel
Various functionalized mono- and diarylanthranilo-1,3-dinitriles were synthesized and evaluated for their in vitro antihyperglycemic activity against the PTP-1B, glucose-6-phosphatase, glycogen phosphorylase and alpha-glucosidase enzymes. Among various screened compounds, 5,6-diaryl substituted anthranilo-1,3-dinitriles 3a, 3b, and 3d showed good inhibitory activity against PTP-1B with IC(50) values of 58-72 microM. Three of the test compounds showed significant (25-37%) lowering of plasma glucose level at 24h in sucrose-challenged streptozotocin-induced diabetic Sprague-Dawley rat model.
Journal of Organic Chemistry | 2007
Atul Goel; Fateh V. Singh; Vijay Kumar; Matthias Reichert; Tobias A. M. Gulder; Gerhard Bringmann
Bioorganic & Medicinal Chemistry Letters | 2004
Atul Goel; Nidhi Agarwal; Fateh V. Singh; Ashoke Sharon; Priti Tiwari; Manish Dixit; Ramendra Pratap; Arvind K. Srivastava; Prakas R. Maulik; Vishnu Ji Ram
Chemistry-an Asian Journal | 2007
Atul Goel; Fateh V. Singh; Manish Dixit; Deepti Verma; Resmi Raghunandan; Prakas R. Maulik
Bioorganic & Medicinal Chemistry Letters | 2006
Fateh V. Singh; Rit Vatsyayan; Uma Roy; Atul Goel
Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms | 2003
Tushar Kumar Mohanty; N. C. Mishra; Fateh V. Singh; Umesh Tiwari; D. Kanjilal
Tetrahedron Letters | 2005
Atul Goel; Fateh V. Singh
Tetrahedron | 2007
Fateh V. Singh; Vijay Kumar; Brijesh Kumar; Atul Goel
Synlett | 2005
Atul Goel; Fateh V. Singh; Ashoke Sharon; Prakas R. Maulik
Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms | 2006
V. Suresh Kumar; P. Puviarasu; K. Thangaraju; R. Thangavel; V. Baranwal; Fateh V. Singh; Tushar Kumar Mohanty; D. Kanjilal; K. Asokan; J. Kumar
Collaboration
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