Fatih Özcura

Ocular Surface Disease Index for the Diagnosis of Dry Eye Syndrome

Purpose: Evaluation of ocular surface disease index (OSDI) questionnaire for the diagnosis of dry eye syndrome. Methods: Sixty-eight patients admitted to the Ophthalmology Polyclinic of the Dumlupinar University between December 2005 and April 2006 were randomly studied. The OSDI questionnaire was performed before, and the Schirmer and tear film breakup time (TBUT) tests were performed after the routine ophthalmologic examination. Results: There was a significant inverse correlation between the OSDI and TBUT test scores, but no correlation between the Schirmer test scores and OSDI (r = −.296, p = .014, r = −.182, p = .138, respectively). Although there was a significant difference between the low and high OSDI having cases according to the TBUT test scores (p = .043), there was not according to the Schirmer test scores. Conclusions: The OSDI is a standardized instrument to evaluate symptoms, and can easily be performed and used to support the diagnosis of dry eye syndrome.

Central corneal thickness and corneal curvature in pseudoexfoliation syndrome with and without glaucoma.

PurposeTo determine the central corneal thickness (CCT) and corneal curvature (CC) in pseudoexfoliative (PE) eyes with and without glaucoma. MethodsCharts of 551 consecutive patients undergoing preoperative examinations for cataract surgery between April 2006 and May 2009 in our clinic were reviewed retrospectively. Fourty-eight PE patients (48 eyes; 19 with glaucoma, 29 without glaucoma) and 48 age-matched and sex-matched control patients were enrolled in the study. The CCT, CC, intraocular pressure, and axial length were measured by ultrasonic pachymeter, autorefractokeratometer, Goldmann applanation tonometry, and ultrasound biometry, respectively. The independent samples t test and paired samples t test was used for the comparisons of the groups. ResultsMean CCT was significantly thinner in all PE and nonglaucomatous PE (Pseudoexfoliation syndrome “PES”) eyes than in control eyes (P=0.004 and P=0.005, respectively). There was no difference in CCT between PE glaucoma (PEG) and control eyes (P=0.089). There was no difference in mean keratometry (K) and axial length in the study and control groups. In 22 unilateral PE eyes, mean CCT and K readings were insignificant between the PE eyes and fellow non-PE eyes. ConclusionsCCT was significantly thinner in eyes with PES compared with control eyes; however, difference between the PEG and control eyes was insignificant. In addition, mean K readings were not different in study and control eyes. Thinner CCT in eyes with PES, both as it is an independent risk factor and as a result of artificially lower intraocular pressure readings, may be an illuminating cause for development and rapid progression of glaucoma in the patients with PES.

Effects of central corneal thickness, central corneal power, and axial length on intraocular pressure measurement assessed with goldmann applanation tonometry

PurposeTo determine the effects of central corneal thickness (CCT), central corneal power (CCP), and axial length (AL) on the measurement of intraocular pressure (IOP) using Goldmann applanation tonometry, and the effects of CCP and AL on CCT.MethodsCharts of 147 consecutive patients undergoing preoperative examinations for cataract surgery between April 2006 and April 2007 in our clinic were reviewed retrospectively. CCT, CCP, and AL were measured by ultrasonic pachymeter (Micropach Model 200P, Sonomed, Lake Success, N.Y. USA), autorefractokeratometer (KR 8800, Topcon, Tokyo, Japan), and ultrasound biometry (EZ Scan AB 5500+ Sonomed, Lake Success, N.Y. USA). Pearson correlation analysis and multiple linear regression analysis were used as indicated, and only one eye of each subject was included in the statistical analysis.ResultsNinety-eight eyes of 98 patients were included in the study. IOP and CCT were significantly and positively correlated (P < 0.001), and CCT and CCP (P = 0.001) were inversely correlated. Multiple regression analysis showed that the effect of CCT on IOP was statistically significant (P < 0.001), but the effects of CCP and AL on IOP were not significant (P = 0.614, P = 0.831, respectively). IOP increased by 0.29 mmHg for each 10 µm increase in CCT.ConclusionsCCT, but not CCP or AL, significantly affected IOP readings obtained by Goldmann applanation tonometry. The effect of CCP on IOP was weak and not significant despite the significant inverse correlation between CCT and CCP.