Fátima R. Fernandes

Brazilian guidelines for the diagnosis and treatment of hereditary angioedema

Hereditary angioedema is an autosomal dominant disease characterized by edema attacks with multiple organ involvement. It is caused by a quantitative or functional deficiency of the C1 inhibitor, which is a member of the serine protease inhibitor family. Hereditary angioedema is unknown to many health professionals and is therefore an underdiagnosed disease. The causes of death from hereditary angioedema include laryngeal edema with asphyxia. The estimated mortality rate in patients in whom the disease goes undetected and who are therefore incorrectly treated is 25-40%. In addition to edema of the glottis, hereditary angioedema often results in edema of the gastrointestinal tract, which can be incapacitating. Patients with hereditary angioedema may undergo unnecessary surgical interventions because the digestive tract can be the primary or only organ system involved, thus mimicking acute surgical abdomen. It is estimated that patients with hereditary angioedema experience some degree of disability 20-100 days per year. The Experts in Clinical Immunology and Allergy of the “Associação Brasileira de Alergia e Imunopatologia - ASBAI” developed these guidelines for the diagnosis, therapy, and management of hereditary angioedema.

Brazilian Guidelines for Hereditary Angioedema Management - 2017 Update Part 1: Definition, Classification and Diagnosis

Hereditary angioedema is an autosomal dominant disease characterized by recurrent angioedema attacks with the involvement of multiple organs. The disease is unknown to many health professionals and is therefore underdiagnosed. Patients who are not adequately diagnosed and treated have an estimated mortality rate ranging from 25% to 40% due to asphyxiation by laryngeal angioedema. Intestinal angioedema is another important and incapacitating presentation that may be the main or only manifestation during an attack. In this article, a group of experts from the “Associação Brasileira de Alergia e Imunologia (ASBAI)” and the “Grupo de Estudos Brasileiro em Angioedema Hereditário (GEBRAEH)” has updated the Brazilian guidelines for the diagnosis and treatment of hereditary angioedema.

Profile of the contact tests standard and cosmetic of the Hospital Público do Servidor Estadual de São Paulo

Methods Retrospective analysis of contact test results, performed with the standard contact test batteries (30 substances) and cosmetics (10 substances) in patients with cutaneous symptoms suggestive of contact dermatitis obtained through database division of Allergy and Immunology of the HSPEIAMSPE in the period January to December 2013. The contact test is recommended by Brazilian Study Group Contact Dermatitis (GBEDC). It was performed reading after 48 and 96 hours, as international criteria Contact Dermatitis Reserch Group (ICDRG,). Statistical analysis by the test of equality of proportions.

Predictive value of use-test in patients with suspected latex allergy

Methods A total of 59 cases were included in this study. Among those, 44 ( 74,5 %) had suggestive clinical history for latex allergy (SCHLA), and were submitted to latex skin prick test (SPT) and serum latex specific IgE test (sIgE– Immulite/Siemens) ; and 15 ( 25,5%) were healthy subjects, wich were considered negative controls for the diagnostic procedure. All the cases were submitted to LUT according to the service’s protocol.

Evaluation of patients with angioedema in accompaniment in the allergy and immunology HSPE / SP

Background Angioedema is defined as delimited edema that compromises dermis and subcutaneous. May have different causes hypersensitivity, autoimmune, idiopathic, physical factors, angiotensin-converting enzyme inhibitors and C1 esterase inhibitor consumption or disability. The physiopathologic mechanisms depend on the cause. In addition to detailed history, additional tests are needed for targeting of etiology. Our Objective was evaluate the profile of patients treated in outpatient Angioedema Allergy and Immunology HSPE.