Fawi M. Abd El Latif

Microwave-assisted reactions: Part 2 One-pot synthesis of pyrimido[1,2-a]pyrimidines

A simple route for the synthesis of pyrimido[1,2-a]pyrimidines by condensation of 2-aminopyrimidine 1, aromatic aldehydes 2 and active methylene reagents 3 under microwave irradiation is reported.

Reactions of 2-Cyano-2-nitrosomethylbenzthiazole: One-Pot Synthesis of New Polyfunctional Pyrazine Derivatives

2-Cyano-2-nitrosomethylbenzthiazole reacts with some active methylene and nucleophile derivatives to yield new fused and isolated polyfunctional pyrazine, -[1,2,4]triazine, -[1,4,5]benzoxadiazepin, -[1,4,5]benzothiadiazepine, [1,4,5]benzotriazepine, -triazole and -triazolo[3,2-c]triazine derivatives in one-pot reaction. The structures were based on IR, MS, and 1 H NMR spectra and elemental data.

NOVEL SYNTHESIS OF POLYFUNCTIONALISED BIARYL, PYRIDAZINE, AND PHTHALAZINE DERIVATIVES

A variety of new biaryl, pyridazine and phthalazine derivatives have been synthesized by reacting ethyl 2-arylhydrazono-3-oxobutyrate with α,β-unsaturated nitriles including acrylonitrile and crotononitrile derivatives.

Ring-Opening Ringn-Closure of 4-Phenyl-1,2-Dithiole-3-Thione. Novel Synthesis of Thio-Pyrano[2,3-B]Pyrane Derivatives

Abstract 1,2-Dithiole-3-thione (1) react with a number of selected α, β-unsaturated nitriles to give thiopyrano(2,3-b]pyrane (3 a,b) and/or pyridine (3c) derivatives in excellent yields. The products result from a ring-opening ring-closure reaction and a concomitant nucleophilic attack at the 5-position of the dithiole ring.

FACILE ONE-POT SYNTHESIS OF 4-ARYL-3-METHYL-1-PHENYLPYRAZOLO[3,4-b]-[1,5]BENZOTHIAZEPINE DERIVATIVES VIA A REGIOSELECTIVE NUCLEOPHILIC ADDITION

4-Arylidene-3-methyl-1-phenylpyrazole-5-one reacts with 2-amino-benzenethiol in ethanol-acetic acid solution to produce a mixture of 4-aryl-3-methyl-1-phenylpyrazolo[3,4-b][1,5]benzothiazepines, 2-arylbenzothiazoles and 3-methyl-1-phenylpyrazole-5-one.4-Arylidene-3-methyl-1-phenylpyrazole-5-one reacts with 2-amino-benzenethiol in ethanol-acetic acid solution to produce a mixture of 4-aryl-3-methyl-1-phenylpyrazolo[3,4-b][1,5]benzothiazepines, 2-arylbenzothiazoles and 3-methyl-1-phenylpyrazole-5-one.

An Efficient and Facile Synthesis of Novel Benzimid-(Thi) Azole Dicarboxaldehydes as a Versatile Precursors for new Ox-, Thi-and Diazepine Derivatives

Abstract Novel 2-cyanomethylbenzimid-(thi)-azole-2,2-dicarboxaldehydes were prepared in quantitative yields and reacted easily with o-aminophenol derivatives to yield new multi-functionallized ox-, thi- and diazepine derivatives in one-pot reaction.Abstract Novel 2-cyanomethylbenzimid-(thi)-azole-2,2-dicarboxaldehydes were prepared in quantitative yields and reacted easily with o-aminophenol derivatives to yield new multi-functionallized ox-, thi- and diazepine derivatives in one-pot reaction.

New Routes for Novel Pyrazolo[3,4- b ][1,6]-naphthyridine, Pyrazolo[3,4- b ]pyridine and Pyrazolo[3,4:2,3]pyrido[6,1- a ]benzimidazole Derivatives

Pyrazolo[3,4-b][1,6]naphthyridine, pyrazolo[3,4-b]pyridine and pyrazolo[3,4:2,3]pyrido[6,1-a]benzimidazole derivatives are synthesized starting from the isomeric 3-substituted 5-chloro-1-phenylpyrazole-4-carbaldehyde.