Federico Moncloa

Response to corticotrophin and correlation between excretion of creatinine and urinary steroids and between the clearance of creatinine and urinary steroids in ageing

Abstract The influence of ageing upon the urinary steroids, the correlation between the excretion of creatinine and the urinary steroids and between the renal clearance of creatinine and urinary steroids were studied in healthy men of different ages. The results show the well established decrease in the urinary excretion of steroids that occurs with ageing. The correlation coefficients demonstrate a good linear correlation with renal clearance of endogenous creatinine, but a poor one with the excretion of creatinine. The response to ACTH is lower in the older group as judged by the urinary 17-keto-steroids and 17,21-dihydroxy-20-keto-steroids.

Radiosulfate space in humans at high altitude.

Summary The extracellular space was studied in young adult males before and during acute exposure to an altitude of 4,300 meters, and also in a group of high altitude permanent residents. The results obtained indicate that during acute exposure to high altitude the sulfate space decreases 1.4 ± 0.2 liters (P<0.01) and that there is no difference between sea level and high altitude natives.

AGTH Stimulation and Dexamethasone Inhibition in Newcomers to High Altitude.

Summary The response to ACTH stimulation and to dexamethasone inhibition was studied in young adult males acutely exposed to an altitude of 14,000 feet. The results indicate that the adrenal cortex can be further stimulated with exogenous ACTH during the first day of exposure to an environment of low oxygen tension. Dexamethasone administration was started the day before the trip to high altitude and depressed the excretion of urinary steroids despite the hypoxic stimulus.

Studies on urinary steroids of men born and living at high altitude.

Summary No differences were found in urinary excretion of steroids between sea level and high altitude natives. The data indicated further that the catabolism of Cortisol was the same in both groups. Inhibition of endogenous ACTH by Dexamethasone did not affect urinary excretion of steroids differently in the 2 groups.