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Featured researches published by Fei Wei.


Clinical Oral Implants Research | 2016

Blood clot formed on rough titanium surface induces early cell recruitment

Jin Yang; Yinghong Zhou; Fei Wei; Yin Xiao

OBJECTIVES The initial contact of blood with biomaterials and subsequent recruitment of inflammatory and marrow-derived stromal cells are among the first phases of bone regeneration. The aim of this study was to investigate the migratory potential of mesenchymal stem cells by treating rat bone marrow mesenchymal stromal cells (rBMSCs) with the extract of the blood clot formed on implant surfaces. MATERIALS AND METHODS Cell attachment and morphology on the blood clot was observed using scanning electron microscopy. The cell metabolism was reflected by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, and the cell proliferation was assessed by the CyQuant(®) assay based on DNA content. Cytokine profiles in the incubation medium derived from different blood-titanium surface were detected using the rat cytokine antibody array. Scratch wound assay and transwell migration assay were performed to determine the effect of blood-implant conditioned medium on cell migration and movement. RESULTS No significant difference was found in cell attachment and morphology on the blood clot formed on smooth and rough surfaces. Increased rBMSC proliferation was induced by the blood clot on rough surfaces. Comparison of cytokine secretion showed a significant increase of CINC-2α, IL-2, L-selectin, MCP-1, prolactin AA and VEGF levels in the elution of blood clot formed on rough titanium surfaces, which led to significantly improved mobility and wound healing ability of rBMSCs. CONCLUSIONS Rough titanium surfaces could influence the blood clot formation and properties, which will induce cell recruitment and stimulate wound healing.


Biomaterials | 2018

Effect of nano-structural properties of biomimetic hydroxyapatite on osteoimmunomodulation

Joanna M. Sadowska; Fei Wei; Jia Guo; Jordi Guillem-Marti; Maria-Pau Ginebra; Yin Xiao

Immune cells are sensitive to the microstructural and textural properties of materials. Tuning the structural features of synthetic bone grafts could be a valuable strategy to regulate the specific response of the immune system, which in turn modulates the activity of bone cells. The aim of this study was to analyse the effect of the structural characteristics of biomimetic calcium deficient hydroxyapatite (CDHA) on the innate immune response of macrophages and the subsequent impact on osteogenesis and osteoclastogenesis. Murine RAW 264.7 cells were cultured, under standard and inflammatory conditions, on chemically identical CDHA substrates that varied in microstructure and porosity. The impact on osteogenesis was evaluated by incubating osteoblastic cells (SaOS-2) with RAW-CDHA conditioned extracts. The results showed that macrophages were sensitive to different textural and structural properties of CDHA. Under standard conditions, the impact of inflammatory cytokine production by RAW cells cultured on CDHA played a significant role in the degradation of substrates, suggesting the impact of resorptive behaviour of RAW cells on biomimetic surfaces. Osteoblast differentiation was stimulated by the conditioned media collected from RAW cells cultured on needle-like nanostructured CDHA. The results demonstrated that needle-like nanostructured CDHA was able to generate a favourable osteoimmune environment to regulate osteoblast differentiation and osteogenesis. Under inflammatory conditions, the incubation of RAW cells with less porous CDHA resulted in a decreased gene expression and release of pro-inflammatory cytokines.


ACS Nano | 2017

Tuning Chemistry and Topography of Nanoengineered Surfaces to Manipulate Immune Response for Bone Regeneration Applications

Akash Bachhuka; Shengwei Han; Fei Wei; Shifeier Lu; Rahul Madathiparambil Visalakshan; Krasimir Vasilev; Yin Xiao


Nanoscale | 2017

Nanoporous microstructures mediate osteogenesis by modulating the osteo-immune response of macrophages.

Siyu Ni; Shengwei Han; Ross Crawford; Shifeier Lu; Fei Wei; Jiang Chang; Chengtie Wu; Yin Xiao


Nanoscale | 2017

Nanotopography-based strategy for the precise manipulation of osteoimmunomodulation in bone regeneration

Akash Bachhuka; Fei Wei; Xiaoshuang Wang; Guanqi Liu; Krasimir Vasilev; Yin Xiao


Journal of Materials Chemistry B | 2018

Alteration of blood clot structure by bone substitute biomaterials (beta-tricalcium phosphate) significantly delays bone healing process

Xin Wang; Yan Luo; Yan Yang; Baoyu Zheng; Fuhua Yan; Fei Wei; Thor Friis; Ross Crawford; Yin Xiao


Institute of Health and Biomedical Innovation; Science & Engineering Faculty | 2018

The immunomodulatory role of BMP-2 on macrophages to accelerate osteogenesis

Fei Wei; Yinghong Zhou; Jing Wang; Changsheng Liu; Yin Xiao


Biomaterials Science | 2018

Blood prefabricated hydroxyapatite/tricalcium phosphate induces ectopic vascularized bone formation via modulating the osteoimmune environment

Fei Wei; Guanqi Liu; Yuanlong Guo; Ross Crawford; Yin Xiao


Institute of Health and Biomedical Innovation; Science & Engineering Faculty | 2017

Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent

Mengchao Shi; Lunguo Xia; Fang Lv; Huiying Zhu; Fei Wei; Shengwei Han; Jiang Chang; Yin Xiao; Chengtie Wu


Institute of Health and Biomedical Innovation | 2017

Nanoporous microstructures mediate osteogenesis by modulating the osteo-immune response of macrophages

Siyu Ni; Shengwei Han; Ross Crawford; Shifeier Lu; Fei Wei; Jiang Chang; Chengtie Wu; Yin Xiao

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Yin Xiao

Queensland University of Technology

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Ross Crawford

Queensland University of Technology

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Shengwei Han

Queensland University of Technology

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Chengtie Wu

Chinese Academy of Sciences

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Jiang Chang

Chinese Academy of Sciences

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Shifeier Lu

Queensland University of Technology

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Guanqi Liu

Sun Yat-sen University

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Akash Bachhuka

University of South Australia

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Krasimir Vasilev

University of South Australia

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