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Dive into the research topics where Felicja Meisel-Mikolajczyk is active.

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Featured researches published by Felicja Meisel-Mikolajczyk.


Journal of Clinical Microbiology | 2003

Recent Emergence of an Epidemic Clindamycin-Resistant Clone of Clostridium difficile among Polish Patients with C. difficile-Associated Diarrhea

Hanna Pituch; Alex van Belkum; Nicole van den Braak; Obuch-Woszczatyński P; Henri A. Verbrugh; Felicja Meisel-Mikolajczyk; Mirosław Łuczak

ABSTRACT Analysis of both the antibiotic resistance and the virulence characteristics of anaerobic human microbial pathogens is important in order to improve our understanding of a number of clinically significant infectious diseases, including Clostridium difficile-associated diarrhea (CDAD). We determined the presence of the clindamycin resistance-associated gene ermB and the ribotype of 33 C. difficile strains isolated from Polish patients suffering from CDAD. While all strains produced cytotoxin B (TcdB), enterotoxin A (TcdA) was produced by a subset of 15 strains only. The results showed that a single ermB-positive, TcdA−B+C. difficile strain with ribotype A has disseminated widely in the two Warsaw hospitals under investigation. Although different strains with the same phenotype were detected, the genotype A strain appeared to be the only one with a clear epidemic character. Apparently, enhanced local spread of CDAD-causing C. difficile may be restricted to a limited number of bacterial genotypes only.


Journal of Clinical Microbiology | 2005

Clonal Spread of a Clostridium difficile Strain with a Complete Set of Toxin A, Toxin B, and Binary Toxin Genes among Polish Patients with Clostridium difficile-Associated Diarrhea

Hanna Pituch; Deborah Kreft; Obuch-Woszczatyński P; Dorota Wultańska; Felicja Meisel-Mikolajczyk; Mirosław Łuczak; Alex van Belkum

ABSTRACT Clinically relevant Clostridium difficile strains usually produce toxins A and B. Some C. difficile strains can produce an additional binary toxin. We report clonality among five strains carrying all toxin genes from Polish patients with C. difficile-associated diarrhea. In another strain, possible recombination between binary toxin genes is documented.


Journal of Clinical Microbiology | 2007

Toxin Profiles and Resistances to Macrolides and Newer Fluoroquinolones as Epidemicity Determinants of Clinical Isolates of Clostridium difficile from Warsaw, Poland

Hanna Pituch; Willem B. van Leeuwen; Kees Maquelin; Dorota Wultańska; Obuch-Woszczatyński P; Nurzyńska G; Haru Kato; Martin Reijans; Felicja Meisel-Mikolajczyk; Mirosław Łuczak; Alex van Belkum

ABSTRACT Amplified fragment length polymorphism genotypes, antibiotic resistance profiles, and toxin profiles of Clostridium difficile strains from Warsaw were determined. The isolates segregate in six major genotypes, coinciding with toxin profiles. Most of the toxin A-negative toxin B-positive toxin CDT-negative strains possess ermB, and several strains were resistant to fluoroquinolones. Resistograms and toxin types of C. difficile strains are epidemicity determinants.


Acta microbiologica Polonica | 1998

Dioctahedral smectite neutralization activity of Clostridium difficile and Bacteroides fragilis toxins in vitro

Martirosian G; Rouyan G; Zalewski T; Felicja Meisel-Mikolajczyk


Clinical Microbiology and Infection | 1997

PCR ribotyping and arbitrarily primed PCR for the comparison of enterotoxigenic Bacteroides fragilis strains from two Polish university hospitals

Gayane Martirosian; Alex van Belkum; Willem B. van Leeuwen; Felicja Meisel-Mikolajczyk; Henri A. Verbrugh


Medical Science Monitor | 2002

Characterization of Clostridium perfringens strains isolated from Polish patients with suspected antibiotic-associated diarrhea.

Obuch-Woszczatyński P; Mirosław Łuczak; Willem B. van Leeuwen; Alex van Belkum; Nicole van den Braak; Hanna Pituch; Henri A. Verbrugh; Felicja Meisel-Mikolajczyk; Gayane Martirosian


Medical Science Monitor | 2001

Acute appendicitis: the role of enterotoxigenic strains of Bacteroides fragilis and Clostridium difficile.

Martirosian G; Bulanda M; Wójcik-Stojek B; Obuch-Woszczatyński P; Rouyan G; Heczko P; Felicja Meisel-Mikolajczyk


Anaerobe | 2000

Are Rapid Immunoassays for in vivo Detection of Toxin A Sufficient for Diagnostic Purposes of Clostridium difficile -Associated Diseases?

Gayane Martirosian; Alex van Belkum; Hanna Pituch; Piotr Obuch-Woszczatyński; Felicja Meisel-Mikolajczyk


Acta microbiologica Polonica | 2003

Influence of clindamycin, metronidazole and polymyxin B on the expression of cell adhesion molecules stimulated by endotoxin and enterotoxin of Bacteroides fragilis

Felicja Meisel-Mikolajczyk; Alicja Rokosz; Katarzyna Kot; Elwira Zawidzka; Cezary Malchar; Maria Nowaczyk; Andrzej Górski


Clinical Microbiology and Infection | 1999

An archival case of clinically significant infection in a surgical patient by enterotoxigenic Bacteroides fragilis: PCR amplification of the metalloprotease enterotoxin gene from non-viable lyophilizates

Alex van Belkum; Piotr Leszczynski; Marius Vogel; Henri A. Verbrugh; Felicja Meisel-Mikolajczyk

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Mirosław Łuczak

Medical University of Warsaw

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Henri A. Verbrugh

Erasmus University Rotterdam

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Dorota Wultańska

Medical University of Warsaw

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Katarzyna Kot

Medical University of Warsaw

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Nicole van den Braak

Erasmus University Rotterdam

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