Felicja Meisel-Mikolajczyk
University of Warsaw
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Publication
Featured researches published by Felicja Meisel-Mikolajczyk.
Journal of Clinical Microbiology | 2003
Hanna Pituch; Alex van Belkum; Nicole van den Braak; Obuch-Woszczatyński P; Henri A. Verbrugh; Felicja Meisel-Mikolajczyk; Mirosław Łuczak
ABSTRACT Analysis of both the antibiotic resistance and the virulence characteristics of anaerobic human microbial pathogens is important in order to improve our understanding of a number of clinically significant infectious diseases, including Clostridium difficile-associated diarrhea (CDAD). We determined the presence of the clindamycin resistance-associated gene ermB and the ribotype of 33 C. difficile strains isolated from Polish patients suffering from CDAD. While all strains produced cytotoxin B (TcdB), enterotoxin A (TcdA) was produced by a subset of 15 strains only. The results showed that a single ermB-positive, TcdA−B+C. difficile strain with ribotype A has disseminated widely in the two Warsaw hospitals under investigation. Although different strains with the same phenotype were detected, the genotype A strain appeared to be the only one with a clear epidemic character. Apparently, enhanced local spread of CDAD-causing C. difficile may be restricted to a limited number of bacterial genotypes only.
Journal of Clinical Microbiology | 2005
Hanna Pituch; Deborah Kreft; Obuch-Woszczatyński P; Dorota Wultańska; Felicja Meisel-Mikolajczyk; Mirosław Łuczak; Alex van Belkum
ABSTRACT Clinically relevant Clostridium difficile strains usually produce toxins A and B. Some C. difficile strains can produce an additional binary toxin. We report clonality among five strains carrying all toxin genes from Polish patients with C. difficile-associated diarrhea. In another strain, possible recombination between binary toxin genes is documented.
Journal of Clinical Microbiology | 2007
Hanna Pituch; Willem B. van Leeuwen; Kees Maquelin; Dorota Wultańska; Obuch-Woszczatyński P; Nurzyńska G; Haru Kato; Martin Reijans; Felicja Meisel-Mikolajczyk; Mirosław Łuczak; Alex van Belkum
ABSTRACT Amplified fragment length polymorphism genotypes, antibiotic resistance profiles, and toxin profiles of Clostridium difficile strains from Warsaw were determined. The isolates segregate in six major genotypes, coinciding with toxin profiles. Most of the toxin A-negative toxin B-positive toxin CDT-negative strains possess ermB, and several strains were resistant to fluoroquinolones. Resistograms and toxin types of C. difficile strains are epidemicity determinants.
Acta microbiologica Polonica | 1998
Martirosian G; Rouyan G; Zalewski T; Felicja Meisel-Mikolajczyk
Clinical Microbiology and Infection | 1997
Gayane Martirosian; Alex van Belkum; Willem B. van Leeuwen; Felicja Meisel-Mikolajczyk; Henri A. Verbrugh
Medical Science Monitor | 2002
Obuch-Woszczatyński P; Mirosław Łuczak; Willem B. van Leeuwen; Alex van Belkum; Nicole van den Braak; Hanna Pituch; Henri A. Verbrugh; Felicja Meisel-Mikolajczyk; Gayane Martirosian
Medical Science Monitor | 2001
Martirosian G; Bulanda M; Wójcik-Stojek B; Obuch-Woszczatyński P; Rouyan G; Heczko P; Felicja Meisel-Mikolajczyk
Anaerobe | 2000
Gayane Martirosian; Alex van Belkum; Hanna Pituch; Piotr Obuch-Woszczatyński; Felicja Meisel-Mikolajczyk
Acta microbiologica Polonica | 2003
Felicja Meisel-Mikolajczyk; Alicja Rokosz; Katarzyna Kot; Elwira Zawidzka; Cezary Malchar; Maria Nowaczyk; Andrzej Górski
Clinical Microbiology and Infection | 1999
Alex van Belkum; Piotr Leszczynski; Marius Vogel; Henri A. Verbrugh; Felicja Meisel-Mikolajczyk